Reviewed, UniProtKB/Swiss-Prot Q9V447 (KRH2_DROME)

Names and origin

Protein names

Recommended name:
    Protein Kr-h2

Gene names

Name:	Kr-h2
ORF Names:	CG9159

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Member of the dosage-dependent hierarchy effective upon white gene expression. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0121 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VZS6	1	EBI-135893,EBI-125601
CG14589	Q9V9K9	1	EBI-135893,EBI-82667
Dip-B	Q9VFQ9	1	EBI-135893,EBI-111771

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Protein Kr-h2		PRO_0000220903
Regions
	Transmembrane	53 – 73	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	181 – 201	21	Potential
Amino acid modifications
	Modified residue	22	1	Phosphoserine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9V447-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1430CC39A1429140	FASTA	276	31,215
	10 20 30 40 50 60 MSAPTDQPPR SEGAQTNSSE RSSQQQEQPQ QSQSQNVPAK LLQHFQTNRI DSALWALRLL 70 80 90 100 110 120 VIFFTVSYVL PIFTSQQSAF SKVMLANAAI SALRLHQRLP AFAFSREFLA RLFAEDSCHY 130 140 150 160 170 180 MMYSLIFFNI RPSLLVLIPV LLYSVLHASS YSLKLLDLIG QNSWWGARFI ISIVEFQAAN 190 200 210 220 230 240 ILKATAFCEI FIMPYAIVLA FMNHAGLMTP VIYYHYLVMR YSSRRNPYPR NAFAELRITF 250 260 270 EALAARSPPA FAKIIRGGIG FVNRLAPQLQ PAAAQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Kruppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila." Benevolenskaya E.V., Frolov M.V., Birchler J.A. Genet. Res. 75:137-142(2000) [PubMed: 10816971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Testis.
[5]	Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C., Celniker S.E. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[6]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF148686 Genomic DNA. Translation: AAD45272.1. AE014134 Genomic DNA. Translation: AAF52341.1. AY118281 mRNA. Translation: AAM48310.1. BT072913 mRNA. Translation: ACN81334.1.
RefSeq	NP_523490.1.
UniGene	Dm.323
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-20347N.
IntAct	Q9V447. 3 interactions.
STRING	Q9V447.
Proteomic databases
PRIDE	Q9V447.
Genome annotation databases
Ensembl	FBtr0079192; FBpp0078823; FBgn0028419; Drosophila melanogaster. [Genome view]
GeneID	33859.
KEGG	dme:Dmel_CG9159.
NMPDR	fig|7227.3.peg.1011.
Organism-specific databases
CTD	33859.
FlyBase	FBgn0028419. Kr-h2.
Phylogenomic databases
InParanoid	Q9V447.
OMA	QTNSSER.
OrthoDB	EOG9ZKJSQ.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-007607-MON.
Gene expression databases
Bgee	Q9V447.
GermOnline	CG9159. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005344. UPF0121. [Graphical view]
Pfam	PF03661. UPF0121. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	785647.

Entry information

Entry name

KRH2_DROME

Accession

Primary (citable) accession number: Q9V447
Secondary accession number(s): C0PV57

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 15, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project