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Protein
Submitted name:

26S proteasome regulatory complex subunit p30

Gene

Rpn12

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • proteasome assembly Source: GO_Central
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • ubiquitin-dependent protein catabolic process Source: FlyBase

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 family signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-8948751. Regulation of PTEN stability and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p30Imported
Submitted name:
RE36854pImported
Submitted name:
Regulatory particle non-ATPase 12Imported
Gene namesi
Name:Rpn12Imported
Synonyms:Dmel\CG4157Imported, dRpn12Imported, p30Imported, S14Imported
ORF Names:CG4157Imported, Dmel_CG4157Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028693. Rpn12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiFBgn0028693.

Interactioni

Protein-protein interaction databases

IntActiQ9V436. 12 interactors.
MINTiMINT-867414.
STRINGi7227.FBpp0075068.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 241CSN8_PSD8_EIF3KInterPro annotationAdd BLAST140

Phylogenomic databases

eggNOGiKOG3151. Eukaryota.
ENOG410XXP2. LUCA.
GeneTreeiENSGT00390000014682.
KOiK03031.
OMAiGAFWSIR.
OrthoDBiEOG091G0G73.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR006746. 26S_Psome_Rpn12.
IPR033464. CSN8_PSD8_EIF3K.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR12387. PTHR12387. 1 hit.
PfamiView protein in Pfam
PF10075. CSN8_PSD8_EIF3K. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVESLYKE LTAEWSKRPP NTVKCGQLLD QLKVALVKMA FLPTDGNDAQ
60 70 80 90 100
SSKKQLILAR SVLEVAVEHS VLSKDLLAFE RYMAQLKCYY YDYAKIIGES
110 120 130 140 150
ESKYKLLGLN LLYLLSGNRV SDFHTELELL SVDVIQHNQF IRPILALEQY
160 170 180 190 200
IMEGRYNKIF QAKSTVPVEV YSYFMDLLLE TVRDEIGACI EKSYDKISAK
210 220 230 240 250
DAAKRLNLRV PDEIKAFGAK RQWKLEASGD YSFTDRSVKP KELLPSEELA
260
EQVLSYARDL EMIV
Length:264
Mass (Da):30,225
Last modified:May 1, 2000 - v1
Checksum:i1B32133866293CD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145314 mRNA. Translation: AAF08395.1.
AE014296 Genomic DNA. Translation: AAF49445.1.
AY084160 mRNA. Translation: AAL89898.1.
RefSeqiNP_648904.1. NM_140647.4.
UniGeneiDm.981.

Genome annotation databases

EnsemblMetazoaiFBtr0075308; FBpp0075068; FBgn0028693.
GeneIDi39845.
KEGGidme:Dmel_CG4157.
UCSCiCG4157-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9V436_DROME
AccessioniPrimary (citable) accession number: Q9V436
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported