Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9V431 (API5_DROME)

Last modified November 24, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Apoptosis inhibitor 5 homolog
      Short name=API-5
Alternative name(s):
    Antiapoptosis clone 11 protein homolog
      Short name=AAC-11
Gene names
Name: Aac11
Synonyms: LD09852
ORF Names: CG6582
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis. Ref.3

Subcellular location

Nucleus By similarity.

Disruption phenotype

Enhanced E2f1-induced apoptosis. Ref.3

Sequence similarities

Belongs to the API5 family.

Hide | Top

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentNucleus
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processanti-apoptosis Ref.3

Inferred from mutant phenotype. Source: UniProtKB

apoptosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hel25EQ272681EBI-151753,EBI-176504

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Apoptosis inhibitor 5 homolog
PRO_0000378097

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9V431-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 207BCC1F52BB69BF

FASTA53659,930
        10         20         30         40         50         60 
MDNIERLYKC YEILSEAGDK ISEHVDEYKE ILKAVKGTSK EKRLASQFIG NFFKHFPDLA 

        70         80         90        100        110        120 
DTAIDAQFDL CEDDDTQIRR QAIKDLPKLC QGNADATIRV GDTLAQLLIL DDPTELQQVN 

       130        140        150        160        170        180 
NSLLAIIKLD TKSSIAGLFQ QISTGDETTR ERCLKFIATK LLTMGPTVIT KEIEDYIVEE 

       190        200        210        220        230        240 
IKKALQDVTA DEFHLCMTIL GATKLGSTIT GHAELVKLAT EQAELNNTDA DIIAVDDEVV 

       250        260        270        280        290        300 
ERFIQCASAA APYFSKTIKS TAFVAHVCDK LLPIKTWNMI ATAVSQDQIQ LRLLKVFAEM 

       310        320        330        340        350        360 
ITNTDKLDNA SERINAVYNV LLEYMPLPKL SDEDLGDTPP SFQFSHAECL LYALHTLGKN 

       370        380        390        400        410        420 
HPNSLSFVED AEKLKDFRAR LQYLARGTQG YIKKLEESLK GKTGEELKTE ENQLKQTALK 

       430        440        450        460        470        480 
TTSNINILIR DLFHSPPIFK HDIVLSWIVP KNNKLGKRHA PITFGEKAAA NGKDKDQEPE 

       490        500        510        520        530 
KKSRPSNDQK FYSPPSGKYS NKVNQSYGNN NRTRQRGGGG GGGSGGGYRN RRFNKY

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo."
Morris E.J., Michaud W.A., Ji J.Y., Moon N.S., Rocco J.W., Dyson N.J.
PLoS Genet. 2:E196-E196(2006) [PubMed: 17112319] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF160921 mRNA. Translation: AAD46861.1.
AE014134 Genomic DNA. Translation: AAF53618.1.
RefSeqNP_477454.1.
UniGeneDm.445

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9V431. 2 interactions.
STRINGQ9V431.

Proteomic databases

PRIDEQ9V431.

Genome annotation databases

EnsemblFBtr0081001; FBpp0080554; FBgn0027885; Drosophila melanogaster. [Genome view]
GeneID35053.
KEGGdme:Dmel_CG6582.
NMPDRfig|7227.3.peg.2754.
UCSCCG6582-RA. d. melanogaster.

Organism-specific databases

CTD35053.
FlyBaseFBgn0027885. Aac11.

Phylogenomic databases

HOGENOMQ9V431.
OMATEQVGQH
OrthoDBEOG9W9JB2

Gene expression databases

ArrayExpressQ9V431.
BgeeQ9V431.

Family and domain databases

InterProIPR008383. API5.
IPR016024. ARM-type_fold.
[Graphical view]
PANTHERPTHR12758:SF11. API5. 1 hit.
PfamPF05918. API5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio791582.

Hide | Top

Entry information

Entry nameAPI5_DROME
AccessionPrimary (citable) accession number: Q9V431
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 1, 2000
Last modified: November 24, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents