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Protein

Apoptosis inhibitor 5 homolog

Gene

Aac11

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis inhibitor 5 homolog
Short name:
API-5
Alternative name(s):
Antiapoptosis clone 11 protein homolog
Short name:
AAC-11
Gene namesi
Name:Aac11
Synonyms:LD09852
ORF Names:CG6582
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0027885 Aac11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Enhanced E2f1-induced apoptosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003780971 – 536Apoptosis inhibitor 5 homologAdd BLAST536

Proteomic databases

PaxDbiQ9V431
PRIDEiQ9V431

Expressioni

Gene expression databases

BgeeiFBgn0027885
GenevisibleiQ9V431 DM

Interactioni

Protein-protein interaction databases

BioGridi61049, 5 interactors
IntActiQ9V431, 2 interactors
MINTiQ9V431
STRINGi7227.FBpp0080554

Structurei

3D structure databases

ProteinModelPortaliQ9V431
SMRiQ9V431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the API5 family.Curated

Phylogenomic databases

eggNOGiKOG2213 Eukaryota
ENOG410XSH0 LUCA
GeneTreeiENSGT00390000010991
InParanoidiQ9V431
OMAiNRSRGRI
OrthoDBiEOG091G06NK
PhylomeDBiQ9V431

Family and domain databases

InterProiView protein in InterPro
IPR008383 API5
IPR016024 ARM-type_fold
PANTHERiPTHR12758:SF19 PTHR12758:SF19, 1 hit
PfamiView protein in Pfam
PF05918 API5, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

Q9V431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNIERLYKC YEILSEAGDK ISEHVDEYKE ILKAVKGTSK EKRLASQFIG
60 70 80 90 100
NFFKHFPDLA DTAIDAQFDL CEDDDTQIRR QAIKDLPKLC QGNADATIRV
110 120 130 140 150
GDTLAQLLIL DDPTELQQVN NSLLAIIKLD TKSSIAGLFQ QISTGDETTR
160 170 180 190 200
ERCLKFIATK LLTMGPTVIT KEIEDYIVEE IKKALQDVTA DEFHLCMTIL
210 220 230 240 250
GATKLGSTIT GHAELVKLAT EQAELNNTDA DIIAVDDEVV ERFIQCASAA
260 270 280 290 300
APYFSKTIKS TAFVAHVCDK LLPIKTWNMI ATAVSQDQIQ LRLLKVFAEM
310 320 330 340 350
ITNTDKLDNA SERINAVYNV LLEYMPLPKL SDEDLGDTPP SFQFSHAECL
360 370 380 390 400
LYALHTLGKN HPNSLSFVED AEKLKDFRAR LQYLARGTQG YIKKLEESLK
410 420 430 440 450
GKTGEELKTE ENQLKQTALK TTSNINILIR DLFHSPPIFK HDIVLSWIVP
460 470 480 490 500
KNNKLGKRHA PITFGEKAAA NGKDKDQEPE KKSRPSNDQK FYSPPSGKYS
510 520 530
NKVNQSYGNN NRTRQRGGGG GGGSGGGYRN RRFNKY
Length:536
Mass (Da):59,930
Last modified:May 1, 2000 - v1
Checksum:i207BCC1F52BB69BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160921 mRNA Translation: AAD46861.1
AE014134 Genomic DNA Translation: AAF53618.1
RefSeqiNP_477454.1, NM_058106.5
UniGeneiDm.445

Genome annotation databases

EnsemblMetazoaiFBtr0081001; FBpp0080554; FBgn0027885
GeneIDi35053
KEGGidme:Dmel_CG6582
UCSCiCG6582-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiAPI5_DROME
AccessioniPrimary (citable) accession number: Q9V431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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