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Protein

Probable cytochrome P450 28a5

Gene

Cyp28a5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi450Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 28a5 (EC:1.14.-.-)
Alternative name(s):
CYPXXVIIIA5
Gene namesi
Name:Cyp28a5
ORF Names:CG8864
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028940 Cyp28a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519881 – 505Probable cytochrome P450 28a5Add BLAST505

Proteomic databases

PaxDbiQ9V419
PRIDEiQ9V419

Expressioni

Gene expression databases

BgeeiFBgn0028940
GenevisibleiQ9V419 DM

Interactioni

Protein-protein interaction databases

IntActiQ9V419, 4 interactors
STRINGi7227.FBpp0080164

Structurei

3D structure databases

ProteinModelPortaliQ9V419
SMRiQ9V419
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
InParanoidiQ9V419
KOiK15005
OMAiGIDAKHM
OrthoDBiEOG091G0JNC
PhylomeDBiQ9V419

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLITLTLVS LVVGLLYAVL VWNYDYWRKR GVPGPKPKLL CGNYPNMFTM
60 70 80 90 100
KRHAIYDLDD IYRQYKNKYD AVGIFGSRSP QLLVINPALA RRVFVSNFKN
110 120 130 140 150
FHDNEIAKNI DEKTDFIFAN NPFSLTGEKW KTRRADVTPG LTMGRIKTVY
160 170 180 190 200
PVTNKVCQKL TEWVEKQLRL GSKDGIDAKH MSLCFTTEMV TDCVLGLGAE
210 220 230 240 250
SFSDKPTPIM SKINDLFNQP WTFVLFFILT SSFPSLSHLI KLRFVPVDVE
260 270 280 290 300
RFFVDLMGSA VETRRAQLAA GKQFERSDFL DYILQLGEKR NLDNRQLLAY
310 320 330 340 350
SMTFLLDGFE TTATVLAHIL LNLGRNKEAQ NLLREEIRSH LQDGTIAFEK
360 370 380 390 400
LSDLPYLDAC VQETIRLFPP GFMSNKLCTE SIEIPNKEGP NFVVEKGTTV
410 420 430 440 450
VVPHYCFMLD EEFFPNPQSF QPERFLEPDA AKTFRERGVF MGFGDGPRVC
460 470 480 490 500
IGMRFATVQI KAAIVELISK FNVKINDKTR KDNDYEPGQI ITGLRGGIWL

DLEKL
Length:505
Mass (Da):57,705
Last modified:May 1, 2000 - v1
Checksum:i292421C5D319BCDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53365.1
AY051533 mRNA Translation: AAK92957.1
RefSeqiNP_609694.1, NM_135850.3
UniGeneiDm.429

Genome annotation databases

EnsemblMetazoaiFBtr0080587; FBpp0080164; FBgn0028940
GeneIDi34817
KEGGidme:Dmel_CG8864
UCSCiCG8864-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiC28A5_DROME
AccessioniPrimary (citable) accession number: Q9V419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health