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Protein

Probable cytochrome P450 28a5

Gene

Cyp28a5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi450 – 4501Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 28a5 (EC:1.14.-.-)
Alternative name(s):
CYPXXVIIIA5
Gene namesi
Name:Cyp28a5
ORF Names:CG8864
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028940. Cyp28a5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Probable cytochrome P450 28a5PRO_0000051988Add
BLAST

Proteomic databases

PaxDbiQ9V419.
PRIDEiQ9V419.

Expressioni

Gene expression databases

BgeeiFBgn0028940.
GenevisibleiQ9V419. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9V419. 4 interactions.
STRINGi7227.FBpp0080164.

Structurei

3D structure databases

ProteinModelPortaliQ9V419.
SMRiQ9V419. Positions 27-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000130641.
InParanoidiQ9V419.
KOiK15005.
OMAiYCFMLDE.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ9V419.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLITLTLVS LVVGLLYAVL VWNYDYWRKR GVPGPKPKLL CGNYPNMFTM
60 70 80 90 100
KRHAIYDLDD IYRQYKNKYD AVGIFGSRSP QLLVINPALA RRVFVSNFKN
110 120 130 140 150
FHDNEIAKNI DEKTDFIFAN NPFSLTGEKW KTRRADVTPG LTMGRIKTVY
160 170 180 190 200
PVTNKVCQKL TEWVEKQLRL GSKDGIDAKH MSLCFTTEMV TDCVLGLGAE
210 220 230 240 250
SFSDKPTPIM SKINDLFNQP WTFVLFFILT SSFPSLSHLI KLRFVPVDVE
260 270 280 290 300
RFFVDLMGSA VETRRAQLAA GKQFERSDFL DYILQLGEKR NLDNRQLLAY
310 320 330 340 350
SMTFLLDGFE TTATVLAHIL LNLGRNKEAQ NLLREEIRSH LQDGTIAFEK
360 370 380 390 400
LSDLPYLDAC VQETIRLFPP GFMSNKLCTE SIEIPNKEGP NFVVEKGTTV
410 420 430 440 450
VVPHYCFMLD EEFFPNPQSF QPERFLEPDA AKTFRERGVF MGFGDGPRVC
460 470 480 490 500
IGMRFATVQI KAAIVELISK FNVKINDKTR KDNDYEPGQI ITGLRGGIWL

DLEKL
Length:505
Mass (Da):57,705
Last modified:May 1, 2000 - v1
Checksum:i292421C5D319BCDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53365.1.
AY051533 mRNA. Translation: AAK92957.1.
RefSeqiNP_609694.1. NM_135850.3.
UniGeneiDm.429.

Genome annotation databases

EnsemblMetazoaiFBtr0080587; FBpp0080164; FBgn0028940.
GeneIDi34817.
KEGGidme:Dmel_CG8864.
UCSCiCG8864-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53365.1.
AY051533 mRNA. Translation: AAK92957.1.
RefSeqiNP_609694.1. NM_135850.3.
UniGeneiDm.429.

3D structure databases

ProteinModelPortaliQ9V419.
SMRiQ9V419. Positions 27-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9V419. 4 interactions.
STRINGi7227.FBpp0080164.

Proteomic databases

PaxDbiQ9V419.
PRIDEiQ9V419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080587; FBpp0080164; FBgn0028940.
GeneIDi34817.
KEGGidme:Dmel_CG8864.
UCSCiCG8864-RA. d. melanogaster.

Organism-specific databases

CTDi34817.
FlyBaseiFBgn0028940. Cyp28a5.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000130641.
InParanoidiQ9V419.
KOiK15005.
OMAiYCFMLDE.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ9V419.

Miscellaneous databases

ChiTaRSiCyp28a5. fly.
GenomeRNAii34817.
PROiQ9V419.

Gene expression databases

BgeeiFBgn0028940.
GenevisibleiQ9V419. DM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC28A5_DROME
AccessioniPrimary (citable) accession number: Q9V419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.