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Q9V407

- AXN_DROME

UniProt

Q9V407 - AXN_DROME

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Protein

Axin

Gene
Axn, CG7926
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).1 Publication

GO - Molecular functioni

  1. beta-catenin binding Source: FlyBase
  2. GTPase activator activity Source: RefGenome
  3. protein kinase binding Source: FlyBase
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. eye-antennal disc morphogenesis Source: FlyBase
  2. heart development Source: FlyBase
  3. imaginal disc-derived wing morphogenesis Source: FlyBase
  4. imaginal disc pattern formation Source: FlyBase
  5. negative regulation of Wnt signaling pathway Source: FlyBase
  6. oogenesis Source: FlyBase
  7. phagocytosis Source: FlyBase
  8. positive regulation of GTPase activity Source: GOC
  9. somatic stem cell maintenance Source: FlyBase
  10. termination of G-protein coupled receptor signaling pathway Source: InterPro
  11. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207070. TCF dependent signaling in response to WNT.
REACT_215026. degradation of AXIN.
REACT_220429. disassembly of the destruction complex and recruitment of AXIN to the membrane.
SignaLinkiQ9V407.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin
Alternative name(s):
Axis inhibition protein
d-Axin
Short name:
dAxin
Gene namesi
Name:Axn
ORF Names:CG7926
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026597. Axn.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745AxinPRO_0000220894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei513 – 5131Phosphothreonine1 Publication
Modified residuei517 – 5171Phosphoserine1 Publication
Modified residuei522 – 5221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V407.
PRIDEiQ9V407.

Expressioni

Developmental stagei

Ubiquitously expressed throughout the development.

Gene expression databases

BgeeiQ9V407.

Interactioni

Subunit structurei

Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.

Protein-protein interaction databases

BioGridi68421. 14 interactions.
DIPiDIP-20929N.
IntActiQ9V407. 1 interaction.
MINTiMINT-926493.

Structurei

3D structure databases

ProteinModelPortaliQ9V407.
SMRiQ9V407. Positions 46-171, 663-745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 172119RGSAdd
BLAST
Domaini663 – 74583DIXAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi640 – 6467Poly-Ser

Sequence similaritiesi

Contains 1 DIX domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG238205.
GeneTreeiENSGT00390000010011.
InParanoidiQ9V407.
KOiK02157.
OMAiRQSAMAN.
OrthoDBiEOG79PJQ0.
PhylomeDBiQ9V407.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V407-1 [UniParc]FASTAAdd to Basket

« Hide

MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN    50
WARTLNHLLE DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK 100
IKQIIGAIYR FLRKSQLSIS DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV 150
EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE RCTSSGATGS GSAGSSGSGG 200
SSLAGACALP PTTASGKQQL PQLVPPGAFI NLPVSSVSGP PAGTCSASGS 250
VYGPSTSASS SGSISATDTL PRSSTLPTLH EDSVLSLCDD FEKVQMQEGG 300
GSLGSGSVGA GARAPDYPIR LTRDLLIATQ KRRLEIRPPG AHGYVYNPST 350
TNTSYVPNSR VDSERASVSS GGRTDSDTMS ISSCSMDGRP YIQRRHSSTE 400
SKAIRQSAMA NKETNTFQVI PRTQRLHSNE HRPLKEEELV SLLIPKLEEV 450
KRKRDLEERA RERNPGAALL TNERSSASDR AFAEAIREKF ALDEDNDQDI 500
LDQHVSRVWK DQTPHRSPGT MSPCPPIPSR RRTATHDSGM VSDGAMSLSG 550
HSMKHSKSMP DHSSCSRKLT NKWPSMNTDS GISMFSADTV TKYKDASSRS 600
GSSTASKLEE AKRRLEDEPR RSRRYAQPPM QHLSQQPLAS FSSSSSGGSI 650
SLPHQPPPLP AKPPETIVVF SFCEEPVPYR IKIPGTQPTL RQFKDYLPRR 700
GHFRFFFKTH CEDPDSPVIQ EEIVNDSDIL PLFGDKAMGL VKPSD 745
Length:745
Mass (Da):81,718
Last modified:May 1, 2000 - v1
Checksum:i31A502528CEE84BA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541R → Q in AAD24886. 1 Publication
Sequence conflicti644 – 6452Missing in AAD24886. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086811 mRNA. Translation: AAD24886.1.
AF091813 mRNA. Translation: AAF21293.1.
AE014297 Genomic DNA. Translation: AAF56993.1.
RefSeqiNP_733336.1. NM_170457.3.
NP_733337.1. NM_170458.2.
UniGeneiDm.7154.

Genome annotation databases

EnsemblMetazoaiFBtr0085553; FBpp0084919; FBgn0026597.
FBtr0085555; FBpp0084921; FBgn0026597.
GeneIDi43565.
KEGGidme:Dmel_CG7926.
UCSCiCG7926-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086811 mRNA. Translation: AAD24886.1 .
AF091813 mRNA. Translation: AAF21293.1 .
AE014297 Genomic DNA. Translation: AAF56993.1 .
RefSeqi NP_733336.1. NM_170457.3.
NP_733337.1. NM_170458.2.
UniGenei Dm.7154.

3D structure databases

ProteinModelPortali Q9V407.
SMRi Q9V407. Positions 46-171, 663-745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68421. 14 interactions.
DIPi DIP-20929N.
IntActi Q9V407. 1 interaction.
MINTi MINT-926493.

Proteomic databases

PaxDbi Q9V407.
PRIDEi Q9V407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085553 ; FBpp0084919 ; FBgn0026597 .
FBtr0085555 ; FBpp0084921 ; FBgn0026597 .
GeneIDi 43565.
KEGGi dme:Dmel_CG7926.
UCSCi CG7926-RA. d. melanogaster.

Organism-specific databases

CTDi 43565.
FlyBasei FBgn0026597. Axn.

Phylogenomic databases

eggNOGi NOG238205.
GeneTreei ENSGT00390000010011.
InParanoidi Q9V407.
KOi K02157.
OMAi RQSAMAN.
OrthoDBi EOG79PJQ0.
PhylomeDBi Q9V407.

Enzyme and pathway databases

Reactomei REACT_207070. TCF dependent signaling in response to WNT.
REACT_215026. degradation of AXIN.
REACT_220429. disassembly of the destruction complex and recruitment of AXIN to the membrane.
SignaLinki Q9V407.

Miscellaneous databases

GenomeRNAii 43565.
NextBioi 834579.
PROi Q9V407.

Gene expression databases

Bgeei Q9V407.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin."
    Hamada F., Tomoyasu Y., Takatsu Y., Nakamura M., Nagai S., Suzuki A., Fujita F., Shibuya H., Toyoshima K., Ueno N., Akiyama T.
    Science 283:1739-1742(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "A Drosophila homolog of the axin gene is involved in the transduction of the wingless signal regulating the stability of the armadillo protein."
    Ruel L., Anthopoulos N., Goncalves J., Manoukian A.S., Woodgett J.R.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "A Drosophila Axin homolog, Daxin, inhibits Wnt signaling."
    Willert K., Logan C.Y., Arora A., Fish M., Nusse R.
    Development 126:4165-4173(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-513; SER-517 AND SER-522, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiAXN_DROME
AccessioniPrimary (citable) accession number: Q9V407
Secondary accession number(s): Q9XYC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi