Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9V407

- AXN_DROME

UniProt

Q9V407 - AXN_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Axin

Gene

Axn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).1 Publication

GO - Molecular functioni

  1. beta-catenin binding Source: FlyBase
  2. GTPase activator activity Source: RefGenome
  3. protein kinase binding Source: FlyBase

GO - Biological processi

  1. eye-antennal disc morphogenesis Source: FlyBase
  2. heart development Source: FlyBase
  3. imaginal disc-derived wing morphogenesis Source: FlyBase
  4. imaginal disc pattern formation Source: FlyBase
  5. negative regulation of Wnt signaling pathway Source: FlyBase
  6. oogenesis Source: FlyBase
  7. phagocytosis Source: FlyBase
  8. positive regulation of GTPase activity Source: GOC
  9. somatic stem cell maintenance Source: FlyBase
  10. termination of G-protein coupled receptor signaling pathway Source: InterPro
  11. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207070. TCF dependent signaling in response to WNT.
REACT_215026. degradation of AXIN.
REACT_220429. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_229546. S45 mutants of beta-catenin aren't phosphorylated.
REACT_239929. misspliced GSK3beta mutants stabilize beta-catenin.
REACT_242866. Degradation of beta-catenin by the destruction complex.
REACT_248684. S33 mutants of beta-catenin aren't phosphorylated.
REACT_248794. Beta-catenin phosphorylation cascade.
REACT_251065. S37 mutants of beta-catenin aren't phosphorylated.
REACT_259707. T41 mutants of beta-catenin aren't phosphorylated.
SignaLinkiQ9V407.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin
Alternative name(s):
Axis inhibition protein
d-Axin
Short name:
dAxin
Gene namesi
Name:Axn
ORF Names:CG7926
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026597. Axn.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745AxinPRO_0000220894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei513 – 5131Phosphothreonine1 Publication
Modified residuei517 – 5171Phosphoserine1 Publication
Modified residuei522 – 5221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V407.
PRIDEiQ9V407.

Expressioni

Developmental stagei

Ubiquitously expressed throughout the development.

Gene expression databases

BgeeiQ9V407.

Interactioni

Subunit structurei

Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.

Protein-protein interaction databases

BioGridi68421. 14 interactions.
DIPiDIP-20929N.
IntActiQ9V407. 1 interaction.
MINTiMINT-926493.

Structurei

3D structure databases

ProteinModelPortaliQ9V407.
SMRiQ9V407. Positions 46-171, 663-745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 172119RGSPROSITE-ProRule annotationAdd
BLAST
Domaini663 – 74583DIXPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi640 – 6467Poly-Ser

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
GeneTreeiENSGT00390000010011.
InParanoidiQ9V407.
KOiK02157.
OMAiRQSAMAN.
OrthoDBiEOG79PJQ0.
PhylomeDBiQ9V407.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN
60 70 80 90 100
WARTLNHLLE DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK
110 120 130 140 150
IKQIIGAIYR FLRKSQLSIS DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV
160 170 180 190 200
EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE RCTSSGATGS GSAGSSGSGG
210 220 230 240 250
SSLAGACALP PTTASGKQQL PQLVPPGAFI NLPVSSVSGP PAGTCSASGS
260 270 280 290 300
VYGPSTSASS SGSISATDTL PRSSTLPTLH EDSVLSLCDD FEKVQMQEGG
310 320 330 340 350
GSLGSGSVGA GARAPDYPIR LTRDLLIATQ KRRLEIRPPG AHGYVYNPST
360 370 380 390 400
TNTSYVPNSR VDSERASVSS GGRTDSDTMS ISSCSMDGRP YIQRRHSSTE
410 420 430 440 450
SKAIRQSAMA NKETNTFQVI PRTQRLHSNE HRPLKEEELV SLLIPKLEEV
460 470 480 490 500
KRKRDLEERA RERNPGAALL TNERSSASDR AFAEAIREKF ALDEDNDQDI
510 520 530 540 550
LDQHVSRVWK DQTPHRSPGT MSPCPPIPSR RRTATHDSGM VSDGAMSLSG
560 570 580 590 600
HSMKHSKSMP DHSSCSRKLT NKWPSMNTDS GISMFSADTV TKYKDASSRS
610 620 630 640 650
GSSTASKLEE AKRRLEDEPR RSRRYAQPPM QHLSQQPLAS FSSSSSGGSI
660 670 680 690 700
SLPHQPPPLP AKPPETIVVF SFCEEPVPYR IKIPGTQPTL RQFKDYLPRR
710 720 730 740
GHFRFFFKTH CEDPDSPVIQ EEIVNDSDIL PLFGDKAMGL VKPSD
Length:745
Mass (Da):81,718
Last modified:May 1, 2000 - v1
Checksum:i31A502528CEE84BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541R → Q in AAD24886. (PubMed:10073940)Curated
Sequence conflicti644 – 6452Missing in AAD24886. (PubMed:10073940)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086811 mRNA. Translation: AAD24886.1.
AF091813 mRNA. Translation: AAF21293.1.
AE014297 Genomic DNA. Translation: AAF56993.1.
RefSeqiNP_733336.1. NM_170457.3.
NP_733337.1. NM_170458.2.
UniGeneiDm.7154.

Genome annotation databases

EnsemblMetazoaiFBtr0085553; FBpp0084919; FBgn0026597.
FBtr0085555; FBpp0084921; FBgn0026597.
GeneIDi43565.
KEGGidme:Dmel_CG7926.
UCSCiCG7926-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086811 mRNA. Translation: AAD24886.1 .
AF091813 mRNA. Translation: AAF21293.1 .
AE014297 Genomic DNA. Translation: AAF56993.1 .
RefSeqi NP_733336.1. NM_170457.3.
NP_733337.1. NM_170458.2.
UniGenei Dm.7154.

3D structure databases

ProteinModelPortali Q9V407.
SMRi Q9V407. Positions 46-171, 663-745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68421. 14 interactions.
DIPi DIP-20929N.
IntActi Q9V407. 1 interaction.
MINTi MINT-926493.

Proteomic databases

PaxDbi Q9V407.
PRIDEi Q9V407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085553 ; FBpp0084919 ; FBgn0026597 .
FBtr0085555 ; FBpp0084921 ; FBgn0026597 .
GeneIDi 43565.
KEGGi dme:Dmel_CG7926.
UCSCi CG7926-RA. d. melanogaster.

Organism-specific databases

CTDi 43565.
FlyBasei FBgn0026597. Axn.

Phylogenomic databases

eggNOGi NOG238205.
GeneTreei ENSGT00390000010011.
InParanoidi Q9V407.
KOi K02157.
OMAi RQSAMAN.
OrthoDBi EOG79PJQ0.
PhylomeDBi Q9V407.

Enzyme and pathway databases

Reactomei REACT_207070. TCF dependent signaling in response to WNT.
REACT_215026. degradation of AXIN.
REACT_220429. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_229546. S45 mutants of beta-catenin aren't phosphorylated.
REACT_239929. misspliced GSK3beta mutants stabilize beta-catenin.
REACT_242866. Degradation of beta-catenin by the destruction complex.
REACT_248684. S33 mutants of beta-catenin aren't phosphorylated.
REACT_248794. Beta-catenin phosphorylation cascade.
REACT_251065. S37 mutants of beta-catenin aren't phosphorylated.
REACT_259707. T41 mutants of beta-catenin aren't phosphorylated.
SignaLinki Q9V407.

Miscellaneous databases

GenomeRNAii 43565.
NextBioi 834579.
PROi Q9V407.

Gene expression databases

Bgeei Q9V407.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin."
    Hamada F., Tomoyasu Y., Takatsu Y., Nakamura M., Nagai S., Suzuki A., Fujita F., Shibuya H., Toyoshima K., Ueno N., Akiyama T.
    Science 283:1739-1742(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "A Drosophila homolog of the axin gene is involved in the transduction of the wingless signal regulating the stability of the armadillo protein."
    Ruel L., Anthopoulos N., Goncalves J., Manoukian A.S., Woodgett J.R.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "A Drosophila Axin homolog, Daxin, inhibits Wnt signaling."
    Willert K., Logan C.Y., Arora A., Fish M., Nusse R.
    Development 126:4165-4173(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-513; SER-517 AND SER-522, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiAXN_DROME
AccessioniPrimary (citable) accession number: Q9V407
Secondary accession number(s): Q9XYC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3