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Protein

Axin

Gene

Axn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).1 Publication

GO - Molecular functioni

  • beta-catenin binding Source: FlyBase
  • GTPase activator activity Source: GO_Central
  • protein-containing complex scaffold activity Source: FlyBase
  • protein kinase binding Source: FlyBase
  • receptor signaling complex scaffold activity Source: InterPro
  • signaling receptor binding Source: FlyBase

GO - Biological processi

  • chitin-based larval cuticle pattern formation Source: FlyBase
  • circadian rhythm Source: Reactome
  • dorsal/ventral pattern formation, imaginal disc Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • heart development Source: FlyBase
  • imaginal disc-derived wing margin morphogenesis Source: FlyBase
  • negative regulation of canonical Wnt signaling pathway Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
  • regulation of cell death Source: FlyBase
  • response to starvation Source: FlyBase
  • segment polarity determination Source: FlyBase
  • somatic stem cell population maintenance Source: FlyBase
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-201681 TCF dependent signaling in response to WNT
R-DME-209155 Phosphorylation of AXN and APC
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209396 Phosphorylation of ARM
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-432553 Phosphorylation of PER and TIM
R-DME-4641257 Degradation of AXIN
R-DME-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DME-5689880 Ub-specific processing proteases
SignaLinkiQ9V407

Names & Taxonomyi

Protein namesi
Recommended name:
Axin
Alternative name(s):
Axis inhibition protein
d-Axin
Short name:
dAxin
Gene namesi
Name:Axn
ORF Names:CG7926
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026597 Axn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208941 – 745AxinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513Phosphothreonine1 Publication1
Modified residuei517Phosphoserine1 Publication1
Modified residuei522Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V407
PRIDEiQ9V407

PTM databases

iPTMnetiQ9V407

Expressioni

Developmental stagei

Ubiquitously expressed throughout the development.

Gene expression databases

BgeeiFBgn0026597
ExpressionAtlasiQ9V407 baseline and differential
GenevisibleiQ9V407 DM

Interactioni

Subunit structurei

Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.

GO - Molecular functioni

  • beta-catenin binding Source: FlyBase
  • protein-containing complex scaffold activity Source: FlyBase
  • protein kinase binding Source: FlyBase
  • receptor signaling complex scaffold activity Source: InterPro
  • signaling receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi68421, 29 interactors
DIPiDIP-20929N
IntActiQ9V407, 2 interactors
MINTiQ9V407
STRINGi7227.FBpp0084919

Structurei

3D structure databases

ProteinModelPortaliQ9V407
SMRiQ9V407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 172RGSPROSITE-ProRule annotationAdd BLAST119
Domaini663 – 745DIXPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi640 – 646Poly-Ser7

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00390000010011
InParanoidiQ9V407
KOiK02157
OMAiIMQWIIE
OrthoDBiEOG091G0ABG
PhylomeDBiQ9V407

Family and domain databases

Gene3Di1.10.196.10, 2 hits
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR029797 AXIN1
IPR014936 Axin_b-cat-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10845:SF11 PTHR10845:SF11, 4 hits
PfamiView protein in Pfam
PF08833 Axin_b-cat_bind, 1 hit
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN
60 70 80 90 100
WARTLNHLLE DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK
110 120 130 140 150
IKQIIGAIYR FLRKSQLSIS DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV
160 170 180 190 200
EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE RCTSSGATGS GSAGSSGSGG
210 220 230 240 250
SSLAGACALP PTTASGKQQL PQLVPPGAFI NLPVSSVSGP PAGTCSASGS
260 270 280 290 300
VYGPSTSASS SGSISATDTL PRSSTLPTLH EDSVLSLCDD FEKVQMQEGG
310 320 330 340 350
GSLGSGSVGA GARAPDYPIR LTRDLLIATQ KRRLEIRPPG AHGYVYNPST
360 370 380 390 400
TNTSYVPNSR VDSERASVSS GGRTDSDTMS ISSCSMDGRP YIQRRHSSTE
410 420 430 440 450
SKAIRQSAMA NKETNTFQVI PRTQRLHSNE HRPLKEEELV SLLIPKLEEV
460 470 480 490 500
KRKRDLEERA RERNPGAALL TNERSSASDR AFAEAIREKF ALDEDNDQDI
510 520 530 540 550
LDQHVSRVWK DQTPHRSPGT MSPCPPIPSR RRTATHDSGM VSDGAMSLSG
560 570 580 590 600
HSMKHSKSMP DHSSCSRKLT NKWPSMNTDS GISMFSADTV TKYKDASSRS
610 620 630 640 650
GSSTASKLEE AKRRLEDEPR RSRRYAQPPM QHLSQQPLAS FSSSSSGGSI
660 670 680 690 700
SLPHQPPPLP AKPPETIVVF SFCEEPVPYR IKIPGTQPTL RQFKDYLPRR
710 720 730 740
GHFRFFFKTH CEDPDSPVIQ EEIVNDSDIL PLFGDKAMGL VKPSD
Length:745
Mass (Da):81,718
Last modified:May 1, 2000 - v1
Checksum:i31A502528CEE84BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454R → Q in AAD24886 (PubMed:10073940).Curated1
Sequence conflicti644 – 645Missing in AAD24886 (PubMed:10073940).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086811 mRNA Translation: AAD24886.1
AF091813 mRNA Translation: AAF21293.1
AE014297 Genomic DNA Translation: AAF56993.1
RefSeqiNP_733336.1, NM_170457.3
NP_733337.1, NM_170458.2
UniGeneiDm.7154

Genome annotation databases

EnsemblMetazoaiFBtr0085553; FBpp0084919; FBgn0026597
FBtr0085555; FBpp0084921; FBgn0026597
GeneIDi43565
KEGGidme:Dmel_CG7926
UCSCiCG7926-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiAXN_DROME
AccessioniPrimary (citable) accession number: Q9V407
Secondary accession number(s): Q9XYC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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