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Protein
Submitted name:

26S proteasome regulatory complex subunit p48A

Gene

Rpt3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p48AImported
Submitted name:
CG16916 proteinImported
Submitted name:
GH06151pImported
Submitted name:
Regulatory particle triple-A ATPase 3, isoform AImported
Submitted name:
Regulatory particle triple-A ATPase 3, isoform BImported (EC:3.-.-.-Imported, EC:3.6.1.3Imported)
Gene namesi
Name:Rpt3Imported
Synonyms:Rpt3-RAImported
ORF Names:CG16916Imported, Dmel_CG16916Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0028686. Rpt3.

Subcellular locationi

GO - Cellular componenti

  • cytosolic proteasome complex Source: GO_Central
  • male germ cell nucleus Source: FlyBase
  • nuclear proteasome complex Source: GO_Central
  • proteasome regulatory particle Source: FlyBase
  • proteasome regulatory particle, base subcomplex Source: FlyBase

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiFBgn0028686.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7227.FBpp0073292.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 332AAAInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0727. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074962.
KOiK03063.
OMAiLIIRNDP.
OrthoDBiEOG091G07NC.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PRINTSiPR00300. CLPPROTEASEA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNMDVLIP EKDELSDLKL KDAHSSLDEL DMEDLYVRYK KLQKTLEFIE
60 70 80 90 100
VQEEYIKDEQ RNLKKEYLHA QEEVKRIQSV PLVIGQFLEA VDQNTGIVGS
110 120 130 140 150
TTGSNYYVRI LSTIDRELLK PSASVALHKH SNALVDVLPP EADSSISMLQ
160 170 180 190 200
PDEKPDVSYA DIGGMDMQKQ EIREAVELPL THFELYKQIG IDPPRGVLMY
210 220 230 240 250
GPPGCGKTML AKAVAHHTTA SFIRVVGSEF VQKYLGEGPR MVRDVFRLAK
260 270 280 290 300
ENAPAIIFID EIDAIATKRF DAQTGADREV QRILLELLNQ MDGFDQTTNV
310 320 330 340 350
KVIMATNRAD TLDPALLRPG RLDRKIEFPL PDRRQKRLVF STITSKMNLS
360 370 380 390 400
EDVDLEEFVA RPDKISGADI NAICQEAGMH AVRENRYIVL AKDFEKGYKN
410
NIKKDEQEHE FYK
Length:413
Mass (Da):46,999
Last modified:May 1, 2000 - v1
Checksum:i34E7518BE593A0E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145306 mRNA. Translation: AAF08387.1.
AE014298 Genomic DNA. Translation: AAF48001.1.
BT046144 mRNA. Translation: ACI46532.1.
AE014298 Genomic DNA. Translation: AHN59578.1.
FN544098 Genomic DNA. Translation: CBA35179.1.
FN544099 Genomic DNA. Translation: CBA35180.1.
FN544100 Genomic DNA. Translation: CBA35181.1.
FN544101 Genomic DNA. Translation: CBA35182.1.
FN544102 Genomic DNA. Translation: CBA35183.1.
FN544103 Genomic DNA. Translation: CBA35184.1.
FN544104 Genomic DNA. Translation: CBA35185.1.
FN544105 Genomic DNA. Translation: CBA35186.1.
FN544106 Genomic DNA. Translation: CBA35187.1.
FN544108 Genomic DNA. Translation: CBA35189.1.
RefSeqiNP_001285108.1. NM_001298179.1.
NP_572686.1. NM_132458.3.
UniGeneiDm.8238.

Genome annotation databases

EnsemblMetazoaiFBtr0073436; FBpp0073292; FBgn0028686.
FBtr0346274; FBpp0312031; FBgn0028686.
GeneIDi32047.
KEGGidme:Dmel_CG16916.
UCSCiCG16916-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9V405_DROME
AccessioniPrimary (citable) accession number: Q9V405
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported