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Protein
Submitted name:

GH11341p

Gene

Rpn5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
GH11341pImported
Submitted name:
Hypothetical 55kDa proteinImported
Submitted name:
Regulatory particle non-ATPase 5Imported
Gene namesi
Name:Rpn5Imported
ORF Names:CG1100Imported, Dmel_CG1100Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028690. Rpn5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nuclear proteasome complex Source: GO_Central
  • proteasome complex Source: FlyBase
  • proteasome regulatory particle Source: FlyBase
  • proteasome regulatory particle, lid subcomplex Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0028690.

Interactioni

Protein-protein interaction databases

IntActiQ9V3Z4. 14 interactors.
MINTiMINT-1656415.
STRINGi7227.FBpp0078278.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini390 – 476PCIInterPro annotationAdd BLAST87

Phylogenomic databases

eggNOGiKOG1498. Eukaryota.
COG5071. LUCA.
GeneTreeiENSGT00730000111110.
KOiK03035.
OMAiKQAITKM.
OrthoDBiEOG091G06CB.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V3Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTYLFDGGR ITKMEVDYEP ACNEKIPLAK ELAKKNPDAF HEAIEMMLQL
60 70 80 90 100
EKQTRLGADM VSCSRVLVAI CQICFDASNW NALNEYVSLL VRRRSQLKQA
110 120 130 140 150
VVKMIQECVT YVDKTPDKET KLKLIDTLRS VTEGKIYVEI ERARLTKILA
160 170 180 190 200
DIKEADGDVA GAATVMEELQ VETYGSMDKR EKVELILEQM RLCLLKEDYV
210 220 230 240 250
STQIIAKKIS IKFFDDPAQH DLKLKFYYLM IQLNRDTSFL NTSRHYQAIA
260 270 280 290 300
EPPRKKTGLT PVDSAASTDE QKKKDDDKKK KEEDDKDKKP EVATEAEVEI
310 320 330 340 350
ELTEEQKKEL TEKLVCAVLY CVLAPFDNEQ SDMMAHLSKN KKLEEVPAYK
360 370 380 390 400
EILRLFMSKE LINFDTFNAD FGLVLAENEM FKDSTKHGKK CITELKDRLI
410 420 430 440 450
EHNIRIIAMY YSRLHLARMS ELLNLPTSRC EEYLSKLANT DTIRVKIDRP
460 470 480 490 500
AGIIYFTQKK SASDILNNWA TDVNQLMSLV NKTCHLINKE ECVYSVMCAV

ED
Length:502
Mass (Da):57,748
Last modified:May 1, 2000 - v1
Checksum:i3DAF2C42C35FBDEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145315 mRNA. Translation: AAF08383.1.
AE014297 Genomic DNA. Translation: AAF51952.1.
AY058339 mRNA. Translation: AAL13568.1.
RefSeqiNP_649588.1. NM_141331.3.
UniGeneiDm.3426.

Genome annotation databases

EnsemblMetazoaiFBtr0078629; FBpp0078278; FBgn0028690.
GeneIDi40717.
KEGGidme:Dmel_CG1100.
UCSCiCG1100-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145315 mRNA. Translation: AAF08383.1.
AE014297 Genomic DNA. Translation: AAF51952.1.
AY058339 mRNA. Translation: AAL13568.1.
RefSeqiNP_649588.1. NM_141331.3.
UniGeneiDm.3426.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9V3Z4. 14 interactors.
MINTiMINT-1656415.
STRINGi7227.FBpp0078278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078629; FBpp0078278; FBgn0028690.
GeneIDi40717.
KEGGidme:Dmel_CG1100.
UCSCiCG1100-RA. d. melanogaster.

Organism-specific databases

CTDi40717.
FlyBaseiFBgn0028690. Rpn5.

Phylogenomic databases

eggNOGiKOG1498. Eukaryota.
COG5071. LUCA.
GeneTreeiENSGT00730000111110.
KOiK03035.
OMAiKQAITKM.
OrthoDBiEOG091G06CB.

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii40717.

Gene expression databases

BgeeiFBgn0028690.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9V3Z4_DROME
AccessioniPrimary (citable) accession number: Q9V3Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.