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Protein
Submitted name:

Serine protease 7, isoform A

Gene

Sp7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • defense response Source: FlyBase
  • melanization defense response Source: FlyBase
  • positive regulation of melanization defense response Source: FlyBase
  • proteolysis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseImported, Hydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.203.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine protease 7, isoform AImported (EC:3.4.16.-Imported, EC:3.4.21.-Imported)
Submitted name:
Serine protease 7, isoform EImported
Submitted name:
Serine protease 7, isoform FImported
Submitted name:
Serine proteinaseImported
Gene namesi
Name:Sp7Imported
ORF Names:CG3066Imported, Dmel_CG3066Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037515. Sp7.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 391364Sequence analysisPRO_5007718041Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiFBgn0037515.

Interactioni

Protein-protein interaction databases

MINTiMINT-336596.
STRINGi7227.FBpp0081237.

Structurei

3D structure databases

SMRiQ9V3Z2. Positions 31-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 390254Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00720000108964.
OMAiFATRNIH.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9V3Z2.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR022700. CLIP.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF12032. CLIP. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00680. CLIP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V3Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTRKVVGI FLATCLLPFT VLQNVAAQGS CRNPNQKQGQ CLSIYDCQSL
60 70 80 90 100
LSVIQQSYVS PEDRTFLRNS QCLDGVGRQP YVCCTSDRSF GSQEATSAAP
110 120 130 140 150
PPTTTSSSSR GQDGQAGLGN LLPSPPKCGP HSFSNKVYNG NDTAIDEFNW
160 170 180 190 200
MALLEYVDNR GRRELSCGGS LINNRYVLTA AHCVIGAVET EVGHLTTVRL
210 220 230 240 250
GEYDTSKDVD CIDDICNQPI LQLGIEQATV HPQYDPANKN RIHDIALLRL
260 270 280 290 300
DRPVVLNEYI QPVCLPLVST RMAINTGELL VVSGWGRTTT ARKSTIKQRL
310 320 330 340 350
DLPVNDHDYC ARKFATRNIH LISSQLCVGG EFYRDSCDGD SGGPLMRRGF
360 370 380 390
DQAWYQEGVV SFGNRCGLEG WPGVYTRVAD YMDWIVETIR P
Length:391
Mass (Da):43,128
Last modified:May 1, 2000 - v1
Checksum:i3E1416F12EDF89F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233093 mRNA. Translation: AAF43410.1.
AE014297 Genomic DNA. Translation: AAF54143.1.
AE014297 Genomic DNA. Translation: AAG22126.1.
AE014297 Genomic DNA. Translation: AAG22127.2.
RefSeqiNP_649734.2. NM_141477.2.
NP_731174.1. NM_169192.3.
NP_731175.2. NM_169193.3.
UniGeneiDm.6983.

Genome annotation databases

EnsemblMetazoaiFBtr0081740; FBpp0081237; FBgn0037515.
FBtr0339180; FBpp0308321; FBgn0037515.
FBtr0339181; FBpp0308322; FBgn0037515.
GeneIDi40918.
KEGGidme:Dmel_CG3066.
UCSCiCG3066-RA. d. melanogaster.
CG3066-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233093 mRNA. Translation: AAF43410.1.
AE014297 Genomic DNA. Translation: AAF54143.1.
AE014297 Genomic DNA. Translation: AAG22126.1.
AE014297 Genomic DNA. Translation: AAG22127.2.
RefSeqiNP_649734.2. NM_141477.2.
NP_731174.1. NM_169192.3.
NP_731175.2. NM_169193.3.
UniGeneiDm.6983.

3D structure databases

SMRiQ9V3Z2. Positions 31-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-336596.
STRINGi7227.FBpp0081237.

Protein family/group databases

MEROPSiS01.203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081740; FBpp0081237; FBgn0037515.
FBtr0339180; FBpp0308321; FBgn0037515.
FBtr0339181; FBpp0308322; FBgn0037515.
GeneIDi40918.
KEGGidme:Dmel_CG3066.
UCSCiCG3066-RA. d. melanogaster.
CG3066-RB. d. melanogaster.

Organism-specific databases

CTDi121340.
FlyBaseiFBgn0037515. Sp7.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00720000108964.
OMAiFATRNIH.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9V3Z2.

Miscellaneous databases

GenomeRNAii40918.

Gene expression databases

BgeeiFBgn0037515.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR022700. CLIP.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF12032. CLIP. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00680. CLIP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9V3Z2_DROME
AccessioniPrimary (citable) accession number: Q9V3Z2
Secondary accession number(s): Q9I7L2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.