ID   INX7_DROME              Reviewed;         438 AA.
AC   Q9V3W6; C6TP24; Q961J1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 151.
DE   RecName: Full=Innexin inx7;
DE            Short=Innexin-7;
DE   AltName: Full=Gap junction protein prp7;
DE   AltName: Full=Pas-related protein 7;
GN   Name=Inx7; Synonyms=prp7; ORFNames=CG2977;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND TISSUE SPECIFICITY.
RC   TISSUE=Head;
RX   PubMed=10352230; DOI=10.1016/s0378-1119(99)00123-7;
RA   Curtin K.D., Zhang Z., Wyman R.J.;
RT   "Drosophila has several genes for gap junction proteins.";
RL   Gene 232:191-201(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Structural components of the gap junctions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=Q9V3W6-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=Q9V3W6-2; Sequence=VSP_028731;
CC   -!- TISSUE SPECIFICITY: Expressed around gut lobes in embryonic stages 15-
CC       17. {ECO:0000269|PubMed:10352230}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; AF137270; AAD50379.1; -; mRNA.
DR   EMBL; AE014298; AAF46228.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAN09192.1; -; Genomic_DNA.
DR   EMBL; AY051561; AAK92985.1; -; mRNA.
DR   EMBL; BT099510; ACU24750.1; -; mRNA.
DR   RefSeq; NP_788872.1; NM_176699.3. [Q9V3W6-1]
DR   AlphaFoldDB; Q9V3W6; -.
DR   BioGRID; 59318; 8.
DR   DIP; DIP-23156N; -.
DR   IntAct; Q9V3W6; 9.
DR   STRING; 7227.FBpp0070994; -.
DR   PaxDb; 7227-FBpp0070994; -.
DR   DNASU; 33027; -.
DR   EnsemblMetazoa; FBtr0071035; FBpp0070994; FBgn0027106. [Q9V3W6-1]
DR   GeneID; 33027; -.
DR   KEGG; dme:Dmel_CG2977; -.
DR   AGR; FB:FBgn0027106; -.
DR   CTD; 33027; -.
DR   FlyBase; FBgn0027106; Inx7.
DR   VEuPathDB; VectorBase:FBgn0027106; -.
DR   eggNOG; ENOG502QS4R; Eukaryota.
DR   HOGENOM; CLU_035763_1_0_1; -.
DR   InParanoid; Q9V3W6; -.
DR   OMA; FFTPTFT; -.
DR   OrthoDB; 2873211at2759; -.
DR   PhylomeDB; Q9V3W6; -.
DR   BioGRID-ORCS; 33027; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 33027; -.
DR   PRO; PR:Q9V3W6; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0027106; Expressed in adult midgut (Drosophila) and 18 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0010496; P:intercellular transport; ISS:FlyBase.
DR   GO; GO:0072375; P:medium-term memory; IMP:FlyBase.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF38; INNEXIN INX7; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
DR   Genevisible; Q9V3W6; DM.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell junction; Cell membrane; Gap junction;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..438
FT                   /note="Innexin inx7"
FT                   /id="PRO_0000208503"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        45..58
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        80..112
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        134..283
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        305..438
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          381..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         2..78
FT                   /note="Missing (in isoform B)"
FT                   /evidence="ECO:0000303|PubMed:12537569"
FT                   /id="VSP_028731"
SQ   SEQUENCE   438 AA;  50669 MW;  4FC84B0FE8ED7705 CRC64;
     MLNTFSSVRQ YLKFDLTRVV IDNIVFKLHY RWTFVILLVA TLLITSRQYI GEHIQCLSDG
     VVSPVINTFC FFTPTFTVVR DQNQTAYRPG SEPPGIGAFD PEKDTIKRHA YYQWVPFVLF
     FQALCFYIPH ALWKSWEGGR IKALVFGLRM VGLTRYLKND SLRIGKLNIP SMAEAEERVK
     DIRRTMIDRM RLNQSWGAHL VFAEVLNLIN LLLQITWTNR FLGGQFLTLG PHALKNRWSD
     ELSVLDLVFP KITKCKFHKF GDSGSIQMHD ALCVMALNIM NEKIYIILWF WYAFLLIVTV
     LGLLWRILTL CFYRNVTFTR WSLYWAKPGQ LDENELLAVI DKCNFSNWMF LFFLRSNLSE
     FLFKKVIYHL ASEFPNPDHD NDVNAYREAP PTPAKNRYPE LSGLDTIDSP LLHLRRNGSP
     SAGGAQGPST SDMAKLPV
//