Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9V3W6 (INX7_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Innexin inx7
Short name=Innexin-7
Alternative name(s):
Gap junction protein prp7
Pas-related protein 7
Gene names
Name:inx7
Synonyms:prp7
ORF Names:CG2977
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural components of the gap junctions.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential. Cell junction › gap junction.

Tissue specificity

Expressed around gut lobes in embryonic stages 15-17. Ref.1

Sequence similarities

Belongs to the pannexin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AtpalphaP13607-11EBI-126914,EBI-213208
Fcp3CP114501EBI-126914,EBI-159556

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9V3W6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9V3W6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Innexin inx7
PRO_0000208503

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4421Helical; Potential
Topological domain45 – 5814Extracellular Potential
Transmembrane59 – 7921Helical; Potential
Topological domain80 – 11233Cytoplasmic Potential
Transmembrane113 – 13321Helical; Potential
Topological domain134 – 283150Extracellular Potential
Transmembrane284 – 30421Helical; Potential
Topological domain305 – 438134Cytoplasmic Potential

Natural variations

Alternative sequence2 – 7877Missing in isoform B.
VSP_028731

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4FC84B0FE8ED7705

FASTA43850,669
        10         20         30         40         50         60 
MLNTFSSVRQ YLKFDLTRVV IDNIVFKLHY RWTFVILLVA TLLITSRQYI GEHIQCLSDG 

        70         80         90        100        110        120 
VVSPVINTFC FFTPTFTVVR DQNQTAYRPG SEPPGIGAFD PEKDTIKRHA YYQWVPFVLF 

       130        140        150        160        170        180 
FQALCFYIPH ALWKSWEGGR IKALVFGLRM VGLTRYLKND SLRIGKLNIP SMAEAEERVK 

       190        200        210        220        230        240 
DIRRTMIDRM RLNQSWGAHL VFAEVLNLIN LLLQITWTNR FLGGQFLTLG PHALKNRWSD 

       250        260        270        280        290        300 
ELSVLDLVFP KITKCKFHKF GDSGSIQMHD ALCVMALNIM NEKIYIILWF WYAFLLIVTV 

       310        320        330        340        350        360 
LGLLWRILTL CFYRNVTFTR WSLYWAKPGQ LDENELLAVI DKCNFSNWMF LFFLRSNLSE 

       370        380        390        400        410        420 
FLFKKVIYHL ASEFPNPDHD NDVNAYREAP PTPAKNRYPE LSGLDTIDSP LLHLRRNGSP 

       430 
SAGGAQGPST SDMAKLPV

« Hide

Isoform B [UniParc].

Checksum: 97A777A7841D4E24
Show »

FASTA36141,727

References

« Hide 'large scale' references
[1]"Drosophila has several genes for gap junction proteins."
Curtin K.D., Zhang Z., Wyman R.J.
Gene 232:191-201(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
Tissue: Head.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF137270 mRNA. Translation: AAD50379.1.
AE014298 Genomic DNA. Translation: AAF46228.1.
AE014298 Genomic DNA. Translation: AAN09192.1.
AY051561 mRNA. Translation: AAK92985.1.
RefSeqNP_788871.1. NM_176698.2.
NP_788872.1. NM_176699.3.
UniGeneDm.230.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-23156N.
IntActQ9V3W6. 2 interactions.
MINTMINT-1561255.

Proteomic databases

PaxDbQ9V3W6.
PRIDEQ9V3W6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0071035; FBpp0070994; FBgn0027106.
GeneID33027.
KEGGdme:Dmel_CG2977.

Organism-specific databases

CTD33027.
FlyBaseFBgn0027106. inx7.

Phylogenomic databases

eggNOGNOG71835.
GeneTreeENSGT00530000064205.
HOGENOMHOG000264132.
InParanoidQ9V3W6.
OMAILNGREW.
OrthoDBEOG4CNP6K.
PhylomeDBQ9V3W6.

Gene expression databases

BgeeQ9V3W6.
GermOnlineCG2977. Drosophila melanogaster.

Family and domain databases

InterProIPR000990. Innexin.
[Graphical view]
PANTHERPTHR11893. PTHR11893. 1 hit.
PfamPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSPR01262. INNEXIN.
PROSITEPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSinx7. drosophila.
GenomeRNAi33027.
NextBio781581.

Entry information

Entry nameINX7_DROME
AccessionPrimary (citable) accession number: Q9V3W6
Secondary accession number(s): Q961J1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents