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Q9V3W6

- INX7_DROME

UniProt

Q9V3W6 - INX7_DROME

Protein

Innexin inx7

Gene

Inx7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Structural components of the gap junctions.By similarity

    GO - Biological processi

    1. imaginal disc-derived wing morphogenesis Source: FlyBase
    2. ion transport Source: UniProtKB-KW
    3. medium-term memory Source: FlyBase

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Innexin inx7
    Short name:
    Innexin-7
    Alternative name(s):
    Gap junction protein prp7
    Pas-related protein 7
    Gene namesi
    Name:Inx7
    Synonyms:prp7
    ORF Names:CG2977
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0027106. Inx7.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation. Cell junctiongap junction By similarity

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. gap junction Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. nucleus Source: FlyBase
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Innexin inx7PRO_0000208503Add
    BLAST

    Proteomic databases

    PaxDbiQ9V3W6.
    PRIDEiQ9V3W6.

    Expressioni

    Tissue specificityi

    Expressed around gut lobes in embryonic stages 15-17.1 Publication

    Gene expression databases

    BgeeiQ9V3W6.

    Interactioni

    Protein-protein interaction databases

    BioGridi59318. 7 interactions.
    DIPiDIP-23156N.
    IntActiQ9V3W6. 2 interactions.
    MINTiMINT-1561255.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 5814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 11233CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini134 – 283150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 438134CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei59 – 7921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei113 – 13321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei284 – 30421HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pannexin family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71835.
    GeneTreeiENSGT00530000064205.
    HOGENOMiHOG000264132.
    InParanoidiQ9V3W6.
    OMAiILNGREW.
    OrthoDBiEOG7B8S40.
    PhylomeDBiQ9V3W6.

    Family and domain databases

    InterProiIPR000990. Innexin.
    [Graphical view]
    PANTHERiPTHR11893. PTHR11893. 1 hit.
    PfamiPF00876. Innexin. 1 hit.
    [Graphical view]
    PRINTSiPR01262. INNEXIN.
    PROSITEiPS51013. PANNEXIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9V3W6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLNTFSSVRQ YLKFDLTRVV IDNIVFKLHY RWTFVILLVA TLLITSRQYI    50
    GEHIQCLSDG VVSPVINTFC FFTPTFTVVR DQNQTAYRPG SEPPGIGAFD 100
    PEKDTIKRHA YYQWVPFVLF FQALCFYIPH ALWKSWEGGR IKALVFGLRM 150
    VGLTRYLKND SLRIGKLNIP SMAEAEERVK DIRRTMIDRM RLNQSWGAHL 200
    VFAEVLNLIN LLLQITWTNR FLGGQFLTLG PHALKNRWSD ELSVLDLVFP 250
    KITKCKFHKF GDSGSIQMHD ALCVMALNIM NEKIYIILWF WYAFLLIVTV 300
    LGLLWRILTL CFYRNVTFTR WSLYWAKPGQ LDENELLAVI DKCNFSNWMF 350
    LFFLRSNLSE FLFKKVIYHL ASEFPNPDHD NDVNAYREAP PTPAKNRYPE 400
    LSGLDTIDSP LLHLRRNGSP SAGGAQGPST SDMAKLPV 438
    Length:438
    Mass (Da):50,669
    Last modified:May 1, 2000 - v1
    Checksum:i4FC84B0FE8ED7705
    GO
    Isoform B (identifier: Q9V3W6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-78: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:361
    Mass (Da):41,727
    Checksum:i97A777A7841D4E24
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 7877Missing in isoform B. 1 PublicationVSP_028731Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137270 mRNA. Translation: AAD50379.1.
    AE014298 Genomic DNA. Translation: AAF46228.1.
    AE014298 Genomic DNA. Translation: AAN09192.1.
    AY051561 mRNA. Translation: AAK92985.1.
    BT099510 mRNA. Translation: ACU24750.1.
    RefSeqiNP_788871.1. NM_176698.2. [Q9V3W6-2]
    NP_788872.1. NM_176699.3. [Q9V3W6-1]
    UniGeneiDm.230.

    Genome annotation databases

    EnsemblMetazoaiFBtr0071035; FBpp0070994; FBgn0027106. [Q9V3W6-1]
    GeneIDi33027.
    KEGGidme:Dmel_CG2977.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137270 mRNA. Translation: AAD50379.1 .
    AE014298 Genomic DNA. Translation: AAF46228.1 .
    AE014298 Genomic DNA. Translation: AAN09192.1 .
    AY051561 mRNA. Translation: AAK92985.1 .
    BT099510 mRNA. Translation: ACU24750.1 .
    RefSeqi NP_788871.1. NM_176698.2. [Q9V3W6-2 ]
    NP_788872.1. NM_176699.3. [Q9V3W6-1 ]
    UniGenei Dm.230.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 59318. 7 interactions.
    DIPi DIP-23156N.
    IntActi Q9V3W6. 2 interactions.
    MINTi MINT-1561255.

    Proteomic databases

    PaxDbi Q9V3W6.
    PRIDEi Q9V3W6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0071035 ; FBpp0070994 ; FBgn0027106 . [Q9V3W6-1 ]
    GeneIDi 33027.
    KEGGi dme:Dmel_CG2977.

    Organism-specific databases

    CTDi 33027.
    FlyBasei FBgn0027106. Inx7.

    Phylogenomic databases

    eggNOGi NOG71835.
    GeneTreei ENSGT00530000064205.
    HOGENOMi HOG000264132.
    InParanoidi Q9V3W6.
    OMAi ILNGREW.
    OrthoDBi EOG7B8S40.
    PhylomeDBi Q9V3W6.

    Miscellaneous databases

    ChiTaRSi inx7. drosophila.
    GenomeRNAii 33027.
    NextBioi 781581.

    Gene expression databases

    Bgeei Q9V3W6.

    Family and domain databases

    InterProi IPR000990. Innexin.
    [Graphical view ]
    PANTHERi PTHR11893. PTHR11893. 1 hit.
    Pfami PF00876. Innexin. 1 hit.
    [Graphical view ]
    PRINTSi PR01262. INNEXIN.
    PROSITEi PS51013. PANNEXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Drosophila has several genes for gap junction proteins."
      Curtin K.D., Zhang Z., Wyman R.J.
      Gene 232:191-201(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
      Tissue: Head.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Head.
    5. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiINX7_DROME
    AccessioniPrimary (citable) accession number: Q9V3W6
    Secondary accession number(s): C6TP24, Q961J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3