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Q9V3W6

- INX7_DROME

UniProt

Q9V3W6 - INX7_DROME

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Protein
Innexin inx7
Gene
Inx7, prp7, CG2977
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Structural components of the gap junctions By similarity.

GO - Biological processi

  1. imaginal disc-derived wing morphogenesis Source: FlyBase
  2. ion transport Source: UniProtKB-KW
  3. medium-term memory Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin inx7
Short name:
Innexin-7
Alternative name(s):
Gap junction protein prp7
Pas-related protein 7
Gene namesi
Name:Inx7
Synonyms:prp7
ORF Names:CG2977
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0027106. Inx7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei24 – 4421Helical; Reviewed prediction
Add
BLAST
Topological domaini45 – 5814Extracellular Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Topological domaini80 – 11233Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Topological domaini134 – 283150Extracellular Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 438134Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. gap junction Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. nucleus Source: FlyBase
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Innexin inx7
PRO_0000208503Add
BLAST

Proteomic databases

PaxDbiQ9V3W6.
PRIDEiQ9V3W6.

Expressioni

Tissue specificityi

Expressed around gut lobes in embryonic stages 15-17.1 Publication

Gene expression databases

BgeeiQ9V3W6.

Interactioni

Protein-protein interaction databases

BioGridi59318. 7 interactions.
DIPiDIP-23156N.
IntActiQ9V3W6. 2 interactions.
MINTiMINT-1561255.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71835.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000264132.
InParanoidiQ9V3W6.
OMAiILNGREW.
OrthoDBiEOG7B8S40.
PhylomeDBiQ9V3W6.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9V3W6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLNTFSSVRQ YLKFDLTRVV IDNIVFKLHY RWTFVILLVA TLLITSRQYI    50
GEHIQCLSDG VVSPVINTFC FFTPTFTVVR DQNQTAYRPG SEPPGIGAFD 100
PEKDTIKRHA YYQWVPFVLF FQALCFYIPH ALWKSWEGGR IKALVFGLRM 150
VGLTRYLKND SLRIGKLNIP SMAEAEERVK DIRRTMIDRM RLNQSWGAHL 200
VFAEVLNLIN LLLQITWTNR FLGGQFLTLG PHALKNRWSD ELSVLDLVFP 250
KITKCKFHKF GDSGSIQMHD ALCVMALNIM NEKIYIILWF WYAFLLIVTV 300
LGLLWRILTL CFYRNVTFTR WSLYWAKPGQ LDENELLAVI DKCNFSNWMF 350
LFFLRSNLSE FLFKKVIYHL ASEFPNPDHD NDVNAYREAP PTPAKNRYPE 400
LSGLDTIDSP LLHLRRNGSP SAGGAQGPST SDMAKLPV 438
Length:438
Mass (Da):50,669
Last modified:May 1, 2000 - v1
Checksum:i4FC84B0FE8ED7705
GO
Isoform B (identifier: Q9V3W6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-78: Missing.

Note: No experimental confirmation available.

Show »
Length:361
Mass (Da):41,727
Checksum:i97A777A7841D4E24
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 7877Missing in isoform B.
VSP_028731Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137270 mRNA. Translation: AAD50379.1.
AE014298 Genomic DNA. Translation: AAF46228.1.
AE014298 Genomic DNA. Translation: AAN09192.1.
AY051561 mRNA. Translation: AAK92985.1.
BT099510 mRNA. Translation: ACU24750.1.
RefSeqiNP_788871.1. NM_176698.2. [Q9V3W6-2]
NP_788872.1. NM_176699.3. [Q9V3W6-1]
UniGeneiDm.230.

Genome annotation databases

EnsemblMetazoaiFBtr0071035; FBpp0070994; FBgn0027106. [Q9V3W6-1]
GeneIDi33027.
KEGGidme:Dmel_CG2977.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137270 mRNA. Translation: AAD50379.1 .
AE014298 Genomic DNA. Translation: AAF46228.1 .
AE014298 Genomic DNA. Translation: AAN09192.1 .
AY051561 mRNA. Translation: AAK92985.1 .
BT099510 mRNA. Translation: ACU24750.1 .
RefSeqi NP_788871.1. NM_176698.2. [Q9V3W6-2 ]
NP_788872.1. NM_176699.3. [Q9V3W6-1 ]
UniGenei Dm.230.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 59318. 7 interactions.
DIPi DIP-23156N.
IntActi Q9V3W6. 2 interactions.
MINTi MINT-1561255.

Proteomic databases

PaxDbi Q9V3W6.
PRIDEi Q9V3W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071035 ; FBpp0070994 ; FBgn0027106 . [Q9V3W6-1 ]
GeneIDi 33027.
KEGGi dme:Dmel_CG2977.

Organism-specific databases

CTDi 33027.
FlyBasei FBgn0027106. Inx7.

Phylogenomic databases

eggNOGi NOG71835.
GeneTreei ENSGT00530000064205.
HOGENOMi HOG000264132.
InParanoidi Q9V3W6.
OMAi ILNGREW.
OrthoDBi EOG7B8S40.
PhylomeDBi Q9V3W6.

Miscellaneous databases

ChiTaRSi inx7. drosophila.
GenomeRNAii 33027.
NextBioi 781581.

Gene expression databases

Bgeei Q9V3W6.

Family and domain databases

InterProi IPR000990. Innexin.
[Graphical view ]
PANTHERi PTHR11893. PTHR11893. 1 hit.
Pfami PF00876. Innexin. 1 hit.
[Graphical view ]
PRINTSi PR01262. INNEXIN.
PROSITEi PS51013. PANNEXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila has several genes for gap junction proteins."
    Curtin K.D., Zhang Z., Wyman R.J.
    Gene 232:191-201(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY.
    Tissue: Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Head.
  5. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiINX7_DROME
AccessioniPrimary (citable) accession number: Q9V3W6
Secondary accession number(s): C6TP24, Q961J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi