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Protein
Submitted name:

26S proteasome regulatory complex subunit p50

Gene

Rpt5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 family signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-8948751. Regulation of PTEN stability and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p50Imported
Submitted name:
GH12068pImported
Submitted name:
Regulatory particle triple-A ATPase 5Imported (EC:3.-.-.-Imported, EC:3.6.1.3Imported)
Gene namesi
Name:Rpt5Imported
Synonyms:anon-WO0153538.10Imported, anon-WO0153538.8Imported, anon-WO0153538.9Imported, BcDNA.GH12068Imported, BcDNA:GH12068Imported, Dm_Rpt5aImported, Dm_Rpt5bImported, Dmel\CG10370Imported, DmTBP-1Imported, dRpt5Imported, l(3)04210Imported, p50Imported, Pros26SImported, Pros26S-RS6AImported, S6'Imported, TBP-1Imported, Tbp-1Imported, tbp-1Imported, Tbp1Imported
ORF Names:CG10370Imported, Dmel_CG10370Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028684. Rpt5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiFBgn0028684.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9V3V6. 6 interactors.
STRINGi7227.FBpp0083843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 347AAAInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0652. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00730000111070.
KOiK03065.
OMAiRACAAQS.
OrthoDBiEOG091G07E0.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45-like.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035254. PSMC3.
PANTHERiPTHR23073:SF39. PTHR23073:SF39. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V3V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTLEDKSI WEDGEESLGE EVMRMSTDEI VSRTRLMDNE IKIMKSEVIR
60 70 80 90 100
ITHEIQAQNE KIKDNTEKIK VNKTLPYLVS NVIELLDVDP QEEEDDGSVT
110 120 130 140 150
VLDNQRKGKC AVIKTSTRQA YFLPVIGLVD AEKLKPGDLV GVNKDSYLIL
160 170 180 190 200
ETLPAEYDAR VKAMEVDERP TEQYSDIGGL DKQIQELIEA VVLPMTHKEK
210 220 230 240 250
FKNLGIHPPK GVLLYGPPGT GKTLLARACA AQTKSTFLKL AGPQLVQMFI
260 270 280 290 300
GDGAKLVRDA FALAKEKAPA IIFIDELDAI GTKRFDSEKA GDREVQRTML
310 320 330 340 350
ELLNQLDGFS STADIKVIAA TNRVDILDPA LLRSGRLDRK IEFPHPNEEA
360 370 380 390 400
RARIMQIHSR KMNVSNDVNF EELSRSTDDF NGAQCKAVCV EAGMIALRRS
410 420
ANSVTHEDFM DAIMEVQAKK KANLNYYA
Length:428
Mass (Da):47,807
Last modified:May 1, 2000 - v1
Checksum:i5635F47A5F57FDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160882 mRNA. Translation: AAD46823.1.
AF145305 mRNA. Translation: AAF08386.1.
AE014297 Genomic DNA. Translation: AAF56177.1.
PIRiT44596.
RefSeqiNP_524464.1. NM_079740.4.
UniGeneiDm.10261.

Genome annotation databases

EnsemblMetazoaiFBtr0084452; FBpp0083843; FBgn0028684.
GeneIDi42805.
KEGGidme:Dmel_CG10370.
UCSCiCG10370-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9V3V6_DROME
AccessioniPrimary (citable) accession number: Q9V3V6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported