Q9V3V6 (Q9V3V6_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
26S proteasome regulatory complex subunit p50 EMBL AAF08386.1

Submitted name:
GH12068p EMBL AAD46823.1
Submitted name:
Tat-binding protein-1 EMBL AAF56177.1
EC=3.6.1.3 EMBL AAF56177.1

Gene names

Name:	Tbp-1 EMBL AAF56177.1 FlyBase FBgn0028684
ORF Names:	CG10370 FlyBase FBgn0028684, Dmel_CG10370 EMBL AAF56177.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AAA ATPase family. RuleBase RU003651

Ontologies

Keywords
Cellular component	Proteasome EMBL AAF08386.1
Ligand	ATP-binding RuleBase RU003651 Nucleotide-binding
Molecular function	Hydrolase EMBL AAF56177.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein catabolic process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from direct assay Ref.1. Source: FlyBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro proteasome regulatory particle Inferred from direct assay Ref.1. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC endopeptidase activity Inferred from direct assay Ref.1. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9V3V6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5635F47A5F57FDAD	FASTA	428	47,807
	10 20 30 40 50 60 MAQTLEDKSI WEDGEESLGE EVMRMSTDEI VSRTRLMDNE IKIMKSEVIR ITHEIQAQNE 70 80 90 100 110 120 KIKDNTEKIK VNKTLPYLVS NVIELLDVDP QEEEDDGSVT VLDNQRKGKC AVIKTSTRQA 130 140 150 160 170 180 YFLPVIGLVD AEKLKPGDLV GVNKDSYLIL ETLPAEYDAR VKAMEVDERP TEQYSDIGGL 190 200 210 220 230 240 DKQIQELIEA VVLPMTHKEK FKNLGIHPPK GVLLYGPPGT GKTLLARACA AQTKSTFLKL 250 260 270 280 290 300 AGPQLVQMFI GDGAKLVRDA FALAKEKAPA IIFIDELDAI GTKRFDSEKA GDREVQRTML 310 320 330 340 350 360 ELLNQLDGFS STADIKVIAA TNRVDILDPA LLRSGRLDRK IEFPHPNEEA RARIMQIHSR 370 380 390 400 410 420 KMNVSNDVNF EELSRSTDDF NGAQCKAVCV EAGMIALRRS ANSVTHEDFM DAIMEVQAKK KANLNYYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme." Hoelzl H., Kapelari B., Kellermann J., Seemueller E., Suemegi M., Udvardy A., Medalia O., Sperling J., Mueller S.A., Engel A., Baumeister W. J. Cell Biol. 150:119-130(2000) [PubMed: 10893261] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD46823.1.
[5]	Tsang G., Brokstein P., Frise E., Harvey D., Evans-Holm M., Lewis S.E., Suh C., Rubin G.M. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD46823.1.
[6]	Hoelzl H. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF160882 mRNA. Translation: AAD46823.1. AF145305 mRNA. Translation: AAF08386.1. AE014297 Genomic DNA. Translation: AAF56177.1.
PIR	T44596.
RefSeq	NP_524464.1. NM_079740.3.
UniGene	Dm.10261.
3D structure databases
HSSP	HSSP built from PDB template 1R7R based on UniProtKB Q01853.
ProteinModelPortal	Q9V3V6.
SMR	Q9V3V6. Positions 164-421.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9V3V6.
Proteomic databases
PRIDE	Q9V3V6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0084452; FBpp0083843; FBgn0028684.
GeneID	42805.
KEGG	dme:Dmel_CG10370.
NMPDR	fig|7227.3.peg.14284.
UCSC	CG10370-RA. d. melanogaster.
Organism-specific databases
CTD	42805.
FlyBase	FBgn0028684. Tbp-1.
Phylogenomic databases
eggNOG	inNOG04827.
InParanoid	Q9V3V6.
OMA	NNRQLPY.
OrthoDB	EOG4FQZ6Z.
PhylomeDB	Q9V3V6.
Enzyme and pathway databases
BRENDA	3.4.25.1. 48.
Gene expression databases
ArrayExpress	Q9V3V6.
Bgee	Q9V3V6.
Family and domain databases
InterPro	IPR005937. 26S_Psome_P45. IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view]
KO	K03065.
Pfam	PF00004. AAA. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01242. 26Sp45. 1 hit.
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	830660.

Entry information

Entry name

Q9V3V6_DROME

Accession

Primary (citable) accession number: Q9V3V6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)