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Protein

H/ACA ribonucleoprotein complex subunit 2-like protein

Gene

NHP2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 2-like protein
Alternative name(s):
H/ACA snoRNP protein NHP2
Nucleolar protein family A member 2-like protein
Gene namesi
Name:NHP2
ORF Names:CG5258
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0029148. NHP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367721 – 160H/ACA ribonucleoprotein complex subunit 2-like proteinAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphoserine1 Publication1
Modified residuei23Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V3U2.

PTM databases

iPTMnetiQ9V3U2.

Expressioni

Gene expression databases

BgeeiFBgn0029148.
ExpressionAtlasiQ9V3U2. differential.
GenevisibleiQ9V3U2. DM.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi68768. 7 interactors.
IntActiQ9V3U2. 4 interactors.
MINTiMINT-306292.
STRINGi7227.FBpp0305289.

Structurei

3D structure databases

ProteinModelPortaliQ9V3U2.
SMRiQ9V3U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3167. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00550000074939.
InParanoidiQ9V3U2.
KOiK11129.
OMAiNIPYCYT.
OrthoDBiEOG091G0VZK.
PhylomeDBiQ9V3U2.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
PfamiView protein in Pfam
PF01248. Ribosomal_L7Ae. 1 hit.
PRINTSiPR00881. L7ARS6FAMILY.
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V3U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVKVERSE DADESVVASG DVTIKEEESY DDKLIFVNAI AKPMAGKKLA
60 70 80 90 100
KKCYKLVKKA MKHKTFLRNG LKDVQTRLRK GETGICIFAG DVTPVDIMCH
110 120 130 140 150
LPAVCEEKGI PYTYTPSRAD LGAAMGVKRG TVALLVRQNE EYKDLYDEVK
160
EELSALNIPV
Length:160
Mass (Da):17,724
Last modified:May 1, 2000 - v1
Checksum:i610BD8CFC35335DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49701.1.
AF217228 Genomic DNA. Translation: AAF27630.1.
BT023752 mRNA. Translation: AAZ41760.1.
RefSeqiNP_001261849.1. NM_001274920.1.
NP_651965.1. NM_143708.3.
UniGeneiDm.7234.

Genome annotation databases

EnsemblMetazoaiFBtr0075698; FBpp0075448; FBgn0029148.
FBtr0333076; FBpp0305289; FBgn0029148.
GeneIDi44005.
KEGGidme:Dmel_CG5258.
UCSCiCG5258-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiNHP2_DROME
AccessioniPrimary (citable) accession number: Q9V3U2
Secondary accession number(s): Q494M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families