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Q9V3U0 (BGML_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase bubblegum-like

EC=6.2.1.3
Gene names
ORF Names:CG4500
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence caution

The sequence AAM12254.1 differs from that shown. Reason: Erroneous termination at position 195. Translated as Gln.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681Long-chain-fatty-acid--CoA ligase bubblegum-like
PRO_0000315818

Regions

Nucleotide binding223 – 2319ATP By similarity
Nucleotide binding414 – 4196ATP By similarity

Sites

Binding site4911ATP By similarity
Binding site5061ATP By similarity
Binding site6391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9V3U0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6310902CC494712E

FASTA68175,152
        10         20         30         40         50         60 
MNDLKPATSY RSTSLHDAVK LRLDEPSSFS QTVPPQTIPE FFKESCEKYS DLPALVWETP 

        70         80         90        100        110        120 
GSGNDGWTTL TFGEYQERVE QAALMLLSVG VEERSSVGIL AFNCPEWFFA EFGALRAGAV 

       130        140        150        160        170        180 
VAGVYPSNSA EAVHHVLATG ESSVCVVDDA QQMAKLRAIK ERLPRLKAVI QLHGPFEAFV 

       190        200        210        220        230        240 
DHEPGYFSWQ KLQEQTFSSE LKEELLARES RIRANECAML IFTSGTVGMP KAVMLSHDNL 

       250        260        270        280        290        300 
VFDTKSAAAH MQDIQVGKES FVSYLPLSHV AAQIFDVFLG LSHAGCVTFA DKDALKGTLI 

       310        320        330        340        350        360 
KTFRKARPTK MFGVPRVFEK LQERLVAAEA KARPYSRLLL ARARAAVAEH QTTLMAGKSP 

       370        380        390        400        410        420 
SIYGNAKYWL ACRVVKPIRE MIGVDNCRVF FTGGAPTSEE LKQFFLGLDI ALGECYGMSE 

       430        440        450        460        470        480 
TSGAITLNVD ISNLYSAGQA CEGVTLKIHE PDCNGQGEIL MRGRLVFMGY LGLPDKTEET 

       490        500        510        520        530        540 
VKEDGWLHSG DLGYIDPKGN LIISGRLKEL IITAGGENIP PVHIEELIKK ELPCVSNVLL 

       550        560        570        580        590        600 
IGDHRKYLTV LLSLKTKCDA KTGIPLDALR EETIEWLRDL DIHETRLSEL LNIPADLQLP 

       610        620        630        640        650        660 
NDTAALAATL EITAKPKLLE AIEEGIKRAN KYAISNAQKV QKFALIAHEF SVATGELGPT 

       670        680 
LKIRRNIVHA KYAKVIERLY K 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-681.
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014134 Genomic DNA. Translation: AAF53370.1.
BT021247 mRNA. Translation: AAX33395.1.
AY095523 mRNA. Translation: AAM12254.1. Sequence problems.
RefSeqNP_609696.1. NM_135852.3.
UniGeneDm.11081.

3D structure databases

ProteinModelPortalQ9V3U0.
SMRQ9V3U0. Positions 35-542.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9V3U0.
PRIDEQ9V3U0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0080591; FBpp0080168; FBgn0028519.
GeneID34822.
KEGGdme:Dmel_CG4500.
UCSCCG4500-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0028519. CG4500.

Phylogenomic databases

eggNOGCOG1022.
GeneTreeENSGT00690000101725.
InParanoidQ9V3U0.
OMALHIIFEE.
OrthoDBEOG7B5WVB.
PhylomeDBQ9V3U0.

Gene expression databases

BgeeQ9V3U0.

Family and domain databases

InterProIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi34822.
NextBio790390.
PROQ9V3U0.

Entry information

Entry nameBGML_DROME
AccessionPrimary (citable) accession number: Q9V3U0
Secondary accession number(s): Q8SWR5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase