Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9V3U0

- BGML_DROME

UniProt

Q9V3U0 - BGML_DROME

Protein

Long-chain-fatty-acid--CoA ligase bubblegum-like

Gene

CG4500

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei491 – 4911ATPBy similarity
    Binding sitei506 – 5061ATPBy similarity
    Binding sitei639 – 6391ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi223 – 2319ATPBy similarity
    Nucleotide bindingi414 – 4196ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB

    GO - Biological processi

    1. long-chain fatty acid metabolic process Source: UniProtKB
    2. mesoderm development Source: FlyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase bubblegum-like (EC:6.2.1.3)
    Gene namesi
    ORF Names:CG4500
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0028519. CG4500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681Long-chain-fatty-acid--CoA ligase bubblegum-likePRO_0000315818Add
    BLAST

    Proteomic databases

    PaxDbiQ9V3U0.
    PRIDEiQ9V3U0.

    Expressioni

    Gene expression databases

    BgeeiQ9V3U0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V3U0.
    SMRiQ9V3U0. Positions 35-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    InParanoidiQ9V3U0.
    OMAiAIYETSA.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiQ9V3U0.

    Family and domain databases

    InterProiIPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9V3U0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDLKPATSY RSTSLHDAVK LRLDEPSSFS QTVPPQTIPE FFKESCEKYS    50
    DLPALVWETP GSGNDGWTTL TFGEYQERVE QAALMLLSVG VEERSSVGIL 100
    AFNCPEWFFA EFGALRAGAV VAGVYPSNSA EAVHHVLATG ESSVCVVDDA 150
    QQMAKLRAIK ERLPRLKAVI QLHGPFEAFV DHEPGYFSWQ KLQEQTFSSE 200
    LKEELLARES RIRANECAML IFTSGTVGMP KAVMLSHDNL VFDTKSAAAH 250
    MQDIQVGKES FVSYLPLSHV AAQIFDVFLG LSHAGCVTFA DKDALKGTLI 300
    KTFRKARPTK MFGVPRVFEK LQERLVAAEA KARPYSRLLL ARARAAVAEH 350
    QTTLMAGKSP SIYGNAKYWL ACRVVKPIRE MIGVDNCRVF FTGGAPTSEE 400
    LKQFFLGLDI ALGECYGMSE TSGAITLNVD ISNLYSAGQA CEGVTLKIHE 450
    PDCNGQGEIL MRGRLVFMGY LGLPDKTEET VKEDGWLHSG DLGYIDPKGN 500
    LIISGRLKEL IITAGGENIP PVHIEELIKK ELPCVSNVLL IGDHRKYLTV 550
    LLSLKTKCDA KTGIPLDALR EETIEWLRDL DIHETRLSEL LNIPADLQLP 600
    NDTAALAATL EITAKPKLLE AIEEGIKRAN KYAISNAQKV QKFALIAHEF 650
    SVATGELGPT LKIRRNIVHA KYAKVIERLY K 681
    Length:681
    Mass (Da):75,152
    Last modified:May 1, 2000 - v1
    Checksum:i6310902CC494712E
    GO

    Sequence cautioni

    The sequence AAM12254.1 differs from that shown. Reason: Erroneous termination at position 195. Translated as Gln.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53370.1.
    BT021247 mRNA. Translation: AAX33395.1.
    AY095523 mRNA. Translation: AAM12254.1. Sequence problems.
    RefSeqiNP_609696.1. NM_135852.3.
    UniGeneiDm.11081.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080591; FBpp0080168; FBgn0028519.
    GeneIDi34822.
    KEGGidme:Dmel_CG4500.
    UCSCiCG4500-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53370.1 .
    BT021247 mRNA. Translation: AAX33395.1 .
    AY095523 mRNA. Translation: AAM12254.1 . Sequence problems.
    RefSeqi NP_609696.1. NM_135852.3.
    UniGenei Dm.11081.

    3D structure databases

    ProteinModelPortali Q9V3U0.
    SMRi Q9V3U0. Positions 35-542.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9V3U0.
    PRIDEi Q9V3U0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080591 ; FBpp0080168 ; FBgn0028519 .
    GeneIDi 34822.
    KEGGi dme:Dmel_CG4500.
    UCSCi CG4500-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0028519. CG4500.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    InParanoidi Q9V3U0.
    OMAi AIYETSA.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi Q9V3U0.

    Miscellaneous databases

    GenomeRNAii 34822.
    NextBioi 790390.
    PROi Q9V3U0.

    Gene expression databases

    Bgeei Q9V3U0.

    Family and domain databases

    InterProi IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-681.
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiBGML_DROME
    AccessioniPrimary (citable) accession number: Q9V3U0
    Secondary accession number(s): Q8SWR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3