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Protein

Very long-chain-fatty-acid--CoA ligase bubblegum

Gene

bgm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates activation of very-long-chain fatty acids. Probably also able to mediate activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei495ATPBy similarity1
Binding sitei510ATPBy similarity1
Binding sitei624ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 237ATPBy similarity9
Nucleotide bindingi417 – 422ATPBy similarity6

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate-CoA ligase activity Source: UniProtKB-EC
  • fatty acid ligase activity Source: FlyBase
  • long-chain fatty acid-CoA ligase activity Source: FlyBase

GO - Biological processi

  • fatty acid biosynthetic process Source: FlyBase
  • fatty acid metabolic process Source: FlyBase
  • long-chain fatty acid metabolic process Source: UniProtKB
  • neuron cellular homeostasis Source: FlyBase
  • positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  • response to endoplasmic reticulum stress Source: FlyBase

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain-fatty-acid--CoA ligase bubblegum (EC:6.2.1.-, EC:6.2.1.3)
Gene namesi
Name:bgm
ORF Names:CG4501
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0027348 bgm

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Adult neurodegeneration, with marked dilation of photoreceptor axons. Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs). Feeding the fly mutant with glyceryl trioleate oil, blocks the accumulation of excess VLCFAs as well as development of the pathology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158171 – 666Very long-chain-fatty-acid--CoA ligase bubblegumAdd BLAST666

Proteomic databases

PaxDbiQ9V3S9
PRIDEiQ9V3S9

Expressioni

Gene expression databases

BgeeiFBgn0027348
ExpressionAtlasiQ9V3S9 differential
GenevisibleiQ9V3S9 DM

Interactioni

Protein-protein interaction databases

BioGridi688402 interactors.
STRINGi7227.FBpp0080167

Structurei

3D structure databases

ProteinModelPortaliQ9V3S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
InParanoidiQ9V3S9
KOiK15013
OMAiCIWFADK
OrthoDBiEOG091G03FO
PhylomeDBiQ9V3S9

Family and domain databases

InterProiView protein in InterPro
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V3S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIDALYNR PGPNRLRQAD AYRTTNRQDA VKIRMAKDGI GAEEPISVPG
60 70 80 90 100
LLKRTVNNYG DYPALRTKNG KNGYHTVTYK QYEQKVHQVA KAFIKLGLEE
110 120 130 140 150
HHSVGVLAFN CAEWFYSAMG AIHARGIIAG IYTTNSADAV QHVLESSHAQ
160 170 180 190 200
IVVVDDAKQM DKIHAIRDKL PKLKAAIQIQ EPYSPYLKKE DGYYRWSEIE
210 220 230 240 250
SMNVSDVEDQ YMTRLENVAI NECCCLVYTS GTVGMPKGVM LSHDNITFDV
260 270 280 290 300
RGIVKAMDRV VVGAESIVSY LPLSHVAAQT VDIYTCAFVA GCIWFADKDA
310 320 330 340 350
LKGTLVKSLQ DARPTRFMGV PRVYEKFQER MVAVASSSGS LKKMLASWAK
360 370 380 390 400
GITLKHYMVS QGKSSGGFRY KIAKSLIMSK VKQALGFDRV LTLASAAAPM
410 420 430 440 450
SPETKKYFLS LDLKIVDAFG MSETAGCHTI CLPDSVGLNT IGKTLPGCES
460 470 480 490 500
KFINKDANGH GELCIRGRHV FMGYIDNKEK TEESLDDDCW LHSGDLGFVD
510 520 530 540 550
DKGYVSLTGR SKEIIITAGG ENIPPVHIEN TIKKELDAIS NAFLVGEQRK
560 570 580 590 600
YLTVLITLKT EVDKDSGEPL DELSHESSVW VKSLGVEHKT VSDILAAGPC
610 620 630 640 650
PKVWKSIEDA IKRANKQSIS NAQKVQKFTI LPHDFSIPTG ELGPTLKVKR
660
NVVSKMYADE IEKLYA
Length:666
Mass (Da):73,611
Last modified:May 1, 2000 - v1
Checksum:i6F437947FE6B922C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212M → K in AAM48344 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53368.1
AY118315 mRNA Translation: AAM48344.1
RefSeqiNP_001285923.1, NM_001298994.1
NP_524698.1, NM_079959.4
UniGeneiDm.23376

Genome annotation databases

EnsemblMetazoaiFBtr0080590; FBpp0080167; FBgn0027348
FBtr0346624; FBpp0312204; FBgn0027348
GeneIDi44117
KEGGidme:Dmel_CG4501
UCSCiCG4501-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiBGM_DROME
AccessioniPrimary (citable) accession number: Q9V3S9
Secondary accession number(s): Q8MT84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome