UniProtKB - Q9V3S9 (BGM_DROME)
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Protein
Very long-chain-fatty-acid--CoA ligase bubblegum
Gene
bgm
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Mediates activation of very-long-chain fatty acids. Probably also able to mediate activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.1 Publication
Catalytic activityi
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 495 | ATPBy similarity | 1 | |
Binding sitei | 510 | ATPBy similarity | 1 | |
Binding sitei | 624 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 229 – 237 | ATPBy similarity | 9 | |
Nucleotide bindingi | 417 – 422 | ATPBy similarity | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- decanoate-CoA ligase activity Source: UniProtKB-EC
- fatty acid ligase activity Source: FlyBase
- long-chain fatty acid-CoA ligase activity Source: FlyBase
GO - Biological processi
- fatty acid biosynthetic process Source: FlyBase
- fatty acid metabolic process Source: FlyBase
- long-chain fatty acid metabolic process Source: UniProtKB
- neuron cellular homeostasis Source: FlyBase
- positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
- response to endoplasmic reticulum stress Source: FlyBase
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-75876 Synthesis of very long-chain fatty acyl-CoAs |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:bgm ORF Names:CG4501 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0027348 bgm |
Subcellular locationi
Pathology & Biotechi
Disruption phenotypei
Adult neurodegeneration, with marked dilation of photoreceptor axons. Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs). Feeding the fly mutant with glyceryl trioleate oil, blocks the accumulation of excess VLCFAs as well as development of the pathology.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315817 | 1 – 666 | Very long-chain-fatty-acid--CoA ligase bubblegumAdd BLAST | 666 |
Proteomic databases
PaxDbi | Q9V3S9 |
PRIDEi | Q9V3S9 |
Expressioni
Gene expression databases
Bgeei | FBgn0027348 |
ExpressionAtlasi | Q9V3S9 differential |
Genevisiblei | Q9V3S9 DM |
Interactioni
Protein-protein interaction databases
BioGridi | 688402 interactors. |
STRINGi | 7227.FBpp0080167 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1256 Eukaryota COG1022 LUCA |
GeneTreei | ENSGT00690000101725 |
InParanoidi | Q9V3S9 |
KOi | K15013 |
OMAi | CIWFADK |
OrthoDBi | EOG091G03FO |
PhylomeDBi | Q9V3S9 |
Family and domain databases
InterProi | View protein in InterPro IPR000873 AMP-dep_Synth/Lig |
Pfami | View protein in Pfam PF00501 AMP-binding, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V3S9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTIDALYNR PGPNRLRQAD AYRTTNRQDA VKIRMAKDGI GAEEPISVPG
60 70 80 90 100
LLKRTVNNYG DYPALRTKNG KNGYHTVTYK QYEQKVHQVA KAFIKLGLEE
110 120 130 140 150
HHSVGVLAFN CAEWFYSAMG AIHARGIIAG IYTTNSADAV QHVLESSHAQ
160 170 180 190 200
IVVVDDAKQM DKIHAIRDKL PKLKAAIQIQ EPYSPYLKKE DGYYRWSEIE
210 220 230 240 250
SMNVSDVEDQ YMTRLENVAI NECCCLVYTS GTVGMPKGVM LSHDNITFDV
260 270 280 290 300
RGIVKAMDRV VVGAESIVSY LPLSHVAAQT VDIYTCAFVA GCIWFADKDA
310 320 330 340 350
LKGTLVKSLQ DARPTRFMGV PRVYEKFQER MVAVASSSGS LKKMLASWAK
360 370 380 390 400
GITLKHYMVS QGKSSGGFRY KIAKSLIMSK VKQALGFDRV LTLASAAAPM
410 420 430 440 450
SPETKKYFLS LDLKIVDAFG MSETAGCHTI CLPDSVGLNT IGKTLPGCES
460 470 480 490 500
KFINKDANGH GELCIRGRHV FMGYIDNKEK TEESLDDDCW LHSGDLGFVD
510 520 530 540 550
DKGYVSLTGR SKEIIITAGG ENIPPVHIEN TIKKELDAIS NAFLVGEQRK
560 570 580 590 600
YLTVLITLKT EVDKDSGEPL DELSHESSVW VKSLGVEHKT VSDILAAGPC
610 620 630 640 650
PKVWKSIEDA IKRANKQSIS NAQKVQKFTI LPHDFSIPTG ELGPTLKVKR
660
NVVSKMYADE IEKLYA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | M → K in AAM48344 (PubMed:12537569).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53368.1 AY118315 mRNA Translation: AAM48344.1 |
RefSeqi | NP_001285923.1, NM_001298994.1 NP_524698.1, NM_079959.4 |
UniGenei | Dm.23376 |
Genome annotation databases
EnsemblMetazoai | FBtr0080590; FBpp0080167; FBgn0027348 FBtr0346624; FBpp0312204; FBgn0027348 |
GeneIDi | 44117 |
KEGGi | dme:Dmel_CG4501 |
UCSCi | CG4501-RA d. melanogaster |
Similar proteinsi
Entry informationi
Entry namei | BGM_DROME | |
Accessioni | Q9V3S9Primary (citable) accession number: Q9V3S9 Secondary accession number(s): Q8MT84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 25, 2018 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |