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Q9V3S9

- BGM_DROME

UniProt

Q9V3S9 - BGM_DROME

Protein

Very long-chain-fatty-acid--CoA ligase bubblegum

Gene

bgm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Mediates activation of very-long-chain fatty acids. Probably also able to mediate activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.1 Publication

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei495 – 4951ATPBy similarity
    Binding sitei510 – 5101ATPBy similarity
    Binding sitei624 – 6241ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi229 – 2379ATPBy similarity
    Nucleotide bindingi417 – 4226ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB

    GO - Biological processi

    1. long-chain fatty acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Very long-chain-fatty-acid--CoA ligase bubblegum (EC:6.2.1.-, EC:6.2.1.3)
    Gene namesi
    Name:bgm
    ORF Names:CG4501
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0027348. bgm.

    Pathology & Biotechi

    Disruption phenotypei

    Adult neurodegeneration, with marked dilation of photoreceptor axons. Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs). Feeding the fly mutant with glyceryl trioleate oil, blocks the accumulation of excess VLCFAs as well as development of the pathology.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666Very long-chain-fatty-acid--CoA ligase bubblegumPRO_0000315817Add
    BLAST

    Proteomic databases

    PaxDbiQ9V3S9.
    PRIDEiQ9V3S9.

    Expressioni

    Gene expression databases

    BgeeiQ9V3S9.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0080167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V3S9.
    SMRiQ9V3S9. Positions 78-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    InParanoidiQ9V3S9.
    KOiK15013.
    OMAiQMYTKKK.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiQ9V3S9.

    Family and domain databases

    InterProiIPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9V3S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTIDALYNR PGPNRLRQAD AYRTTNRQDA VKIRMAKDGI GAEEPISVPG    50
    LLKRTVNNYG DYPALRTKNG KNGYHTVTYK QYEQKVHQVA KAFIKLGLEE 100
    HHSVGVLAFN CAEWFYSAMG AIHARGIIAG IYTTNSADAV QHVLESSHAQ 150
    IVVVDDAKQM DKIHAIRDKL PKLKAAIQIQ EPYSPYLKKE DGYYRWSEIE 200
    SMNVSDVEDQ YMTRLENVAI NECCCLVYTS GTVGMPKGVM LSHDNITFDV 250
    RGIVKAMDRV VVGAESIVSY LPLSHVAAQT VDIYTCAFVA GCIWFADKDA 300
    LKGTLVKSLQ DARPTRFMGV PRVYEKFQER MVAVASSSGS LKKMLASWAK 350
    GITLKHYMVS QGKSSGGFRY KIAKSLIMSK VKQALGFDRV LTLASAAAPM 400
    SPETKKYFLS LDLKIVDAFG MSETAGCHTI CLPDSVGLNT IGKTLPGCES 450
    KFINKDANGH GELCIRGRHV FMGYIDNKEK TEESLDDDCW LHSGDLGFVD 500
    DKGYVSLTGR SKEIIITAGG ENIPPVHIEN TIKKELDAIS NAFLVGEQRK 550
    YLTVLITLKT EVDKDSGEPL DELSHESSVW VKSLGVEHKT VSDILAAGPC 600
    PKVWKSIEDA IKRANKQSIS NAQKVQKFTI LPHDFSIPTG ELGPTLKVKR 650
    NVVSKMYADE IEKLYA 666
    Length:666
    Mass (Da):73,611
    Last modified:May 1, 2000 - v1
    Checksum:i6F437947FE6B922C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121M → K in AAM48344. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53368.1.
    AY118315 mRNA. Translation: AAM48344.1.
    RefSeqiNP_524698.1. NM_079959.3.
    UniGeneiDm.23376.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080590; FBpp0080167; FBgn0027348.
    GeneIDi44117.
    KEGGidme:Dmel_CG4501.
    UCSCiCG4501-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53368.1 .
    AY118315 mRNA. Translation: AAM48344.1 .
    RefSeqi NP_524698.1. NM_079959.3.
    UniGenei Dm.23376.

    3D structure databases

    ProteinModelPortali Q9V3S9.
    SMRi Q9V3S9. Positions 78-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0080167.

    Proteomic databases

    PaxDbi Q9V3S9.
    PRIDEi Q9V3S9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080590 ; FBpp0080167 ; FBgn0027348 .
    GeneIDi 44117.
    KEGGi dme:Dmel_CG4501.
    UCSCi CG4501-RA. d. melanogaster.

    Organism-specific databases

    CTDi 44117.
    FlyBasei FBgn0027348. bgm.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    InParanoidi Q9V3S9.
    KOi K15013.
    OMAi QMYTKKK.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi Q9V3S9.

    Miscellaneous databases

    ChiTaRSi ACSBG1. drosophila.
    GenomeRNAii 44117.
    NextBioi 836801.
    PROi Q9V3S9.

    Gene expression databases

    Bgeei Q9V3S9.

    Family and domain databases

    InterProi IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Ovary.
    4. "Preventing neurodegeneration in the Drosophila mutant bubblegum."
      Min K.-T., Benzer S.
      Science 284:1985-1988(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME ACTIVITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiBGM_DROME
    AccessioniPrimary (citable) accession number: Q9V3S9
    Secondary accession number(s): Q8MT84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3