SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9V3S9

- BGM_DROME

UniProt

Q9V3S9 - BGM_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Very long-chain-fatty-acid--CoA ligase bubblegum
Gene
bgm, CG4501
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates activation of very-long-chain fatty acids. Probably also able to mediate activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei495 – 4951ATP By similarity
Binding sitei510 – 5101ATP By similarity
Binding sitei624 – 6241ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATP By similarity
Nucleotide bindingi417 – 4226ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. long-chain fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain-fatty-acid--CoA ligase bubblegum (EC:6.2.1.-, EC:6.2.1.3)
Gene namesi
Name:bgm
ORF Names:CG4501
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0027348. bgm.

Pathology & Biotechi

Disruption phenotypei

Adult neurodegeneration, with marked dilation of photoreceptor axons. Effects are probably due to elevated levels of very long chain fatty acids (VLCFAs). Feeding the fly mutant with glyceryl trioleate oil, blocks the accumulation of excess VLCFAs as well as development of the pathology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Very long-chain-fatty-acid--CoA ligase bubblegum
PRO_0000315817Add
BLAST

Proteomic databases

PaxDbiQ9V3S9.
PRIDEiQ9V3S9.

Expressioni

Gene expression databases

BgeeiQ9V3S9.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0080167.

Structurei

3D structure databases

ProteinModelPortaliQ9V3S9.
SMRiQ9V3S9. Positions 78-589.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
InParanoidiQ9V3S9.
KOiK15013.
OMAiQMYTKKK.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ9V3S9.

Family and domain databases

InterProiIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V3S9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTIDALYNR PGPNRLRQAD AYRTTNRQDA VKIRMAKDGI GAEEPISVPG    50
LLKRTVNNYG DYPALRTKNG KNGYHTVTYK QYEQKVHQVA KAFIKLGLEE 100
HHSVGVLAFN CAEWFYSAMG AIHARGIIAG IYTTNSADAV QHVLESSHAQ 150
IVVVDDAKQM DKIHAIRDKL PKLKAAIQIQ EPYSPYLKKE DGYYRWSEIE 200
SMNVSDVEDQ YMTRLENVAI NECCCLVYTS GTVGMPKGVM LSHDNITFDV 250
RGIVKAMDRV VVGAESIVSY LPLSHVAAQT VDIYTCAFVA GCIWFADKDA 300
LKGTLVKSLQ DARPTRFMGV PRVYEKFQER MVAVASSSGS LKKMLASWAK 350
GITLKHYMVS QGKSSGGFRY KIAKSLIMSK VKQALGFDRV LTLASAAAPM 400
SPETKKYFLS LDLKIVDAFG MSETAGCHTI CLPDSVGLNT IGKTLPGCES 450
KFINKDANGH GELCIRGRHV FMGYIDNKEK TEESLDDDCW LHSGDLGFVD 500
DKGYVSLTGR SKEIIITAGG ENIPPVHIEN TIKKELDAIS NAFLVGEQRK 550
YLTVLITLKT EVDKDSGEPL DELSHESSVW VKSLGVEHKT VSDILAAGPC 600
PKVWKSIEDA IKRANKQSIS NAQKVQKFTI LPHDFSIPTG ELGPTLKVKR 650
NVVSKMYADE IEKLYA 666
Length:666
Mass (Da):73,611
Last modified:May 1, 2000 - v1
Checksum:i6F437947FE6B922C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121M → K in AAM48344. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53368.1.
AY118315 mRNA. Translation: AAM48344.1.
RefSeqiNP_524698.1. NM_079959.3.
UniGeneiDm.23376.

Genome annotation databases

EnsemblMetazoaiFBtr0080590; FBpp0080167; FBgn0027348.
GeneIDi44117.
KEGGidme:Dmel_CG4501.
UCSCiCG4501-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53368.1 .
AY118315 mRNA. Translation: AAM48344.1 .
RefSeqi NP_524698.1. NM_079959.3.
UniGenei Dm.23376.

3D structure databases

ProteinModelPortali Q9V3S9.
SMRi Q9V3S9. Positions 78-589.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0080167.

Proteomic databases

PaxDbi Q9V3S9.
PRIDEi Q9V3S9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080590 ; FBpp0080167 ; FBgn0027348 .
GeneIDi 44117.
KEGGi dme:Dmel_CG4501.
UCSCi CG4501-RA. d. melanogaster.

Organism-specific databases

CTDi 44117.
FlyBasei FBgn0027348. bgm.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000101725.
InParanoidi Q9V3S9.
KOi K15013.
OMAi QMYTKKK.
OrthoDBi EOG7B5WVB.
PhylomeDBi Q9V3S9.

Miscellaneous databases

ChiTaRSi ACSBG1. drosophila.
GenomeRNAii 44117.
NextBioi 836801.
PROi Q9V3S9.

Gene expression databases

Bgeei Q9V3S9.

Family and domain databases

InterProi IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Ovary.
  4. "Preventing neurodegeneration in the Drosophila mutant bubblegum."
    Min K.-T., Benzer S.
    Science 284:1985-1988(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiBGM_DROME
AccessioniPrimary (citable) accession number: Q9V3S9
Secondary accession number(s): Q8MT84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi