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Reviewed, UniProtKB/Swiss-Prot Q9V3R1 (A36DE_DROME)

Last modified June 16, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Accessory gland protein Acp36DE
Gene names
Name: Acp36DE
ORF Names: CG7157
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to acts as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm. Ref.1 Ref.8

Subcellular location

Secreted Probable.

Tissue specificity

Main cells of accessory gland and seminal fluid. Ref.1

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Ontologies

Keywords
   Biological processBehavior
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmating plug formation

Traceable author statement. Source: FlyBase

negative regulation of female receptivity, post-mating Ref.1

Non-traceable author statement. Source: UniProtKB

sperm storage

Inferred from mutant phenotype. Source: FlyBase

   Cellular componentextracellular region Ref.1

Traceable author statement. Source: UniProtKB

   Molecular functionhormone activity Ref.1

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 912889Accessory gland protein Acp36DE
PRO_0000020583

Regions

Compositional bias183 – 897715Gln/Ser-rich

Natural variations

Natural variant1481N → S in strain: WSII16.
Natural variant1901A → V in strain: WSII16.
Natural variant1981T → S in strain: SENGWA2, SENGWA22, SENGWA29, SENGWA32, SENGWA37, SENGWA51, WSII19 and WSII49.
Natural variant2231Missing in strain: SENGWA22.
Natural variant2311E → G in strain: WSII6.
Natural variant2531Q → QSQ in strain: SENGWA2, SENGWA29, SENGWA32, SENGWA51, WSII19 and WSII49.
Natural variant3071E → G in strain: WSII6.
Natural variant3161I → F in strain: WSII16.
Natural variant3251K → T in strain: SENGWA37.
Natural variant3351S → P in strain: SENGWA30.
Natural variant3521Q → QLLREAQQK in strain: SENGWA2, SENGWA22, SENGWA29, SENGWA30, SENGWA32, SENGWA37, SENGWA51, WSII16, WSII19 and WSII49.
Natural variant3851F → HQN in strain: WSII1.
Natural variant4301V → I in strain: WSII16.
Natural variant4641L → F in strain: Canton-S, SENGWA2, SENGWA22, SENGWA29, SENGWA32 and SENGWA51.
Natural variant4961E → G in strain: WSII6.
Natural variant5071L → V in strain: SENGWA22, SENGWA29, SENGWA37 and SENGWA51.
Natural variant5751L → Q in strain: WSII16.
Natural variant6011S → I in strain: WSII26 and WSII49.
Natural variant6131E → K in strain: SENGWA30.
Natural variant6501P → A in strain: SENGWA22, SENGWA30 and WSII16.
Natural variant6661L → V in strain: SENGWA29, SENGWA30, SENGWA37 and SENGWA51.
Natural variant6701G → E in strain: SENGWA29, SENGWA30, SENGWA37 and SENGWA51.
Natural variant7581T → A in strain: SENGWA37 and SENGWA51.
Natural variant782 – 7865Missing in strain: SENGWA37 and SENGWA51.
Natural variant8301Q → E in strain: WSII26.
Natural variant8441Q → R in strain: WSII16.

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Sequences

Sequence LengthMass (Da)Tools
Q9V3R1-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 81E2C53431EAFBC5

FASTA912101,921
        10         20         30         40         50         60 
MWTLTCQQFI ALILLGTLVP SESFLCKHCF RKNLEKVHES FRDILSPPIF GVNPQPLIEV 

        70         80         90        100        110        120 
QQPKVTPKPE SSQVIHVHQP QVILKPIYYP KVDTISTKNQ IGIHGPYSQY PSLLPSANLL 

       130        140        150        160        170        180 
GIPNQQLINA QDVLSDKDQK QTQVQNNNLH IRFGVSALRE GRNNPSLETI SRDKVDKISP 

       190        200        210        220        230        240 
ALQLQLLRYA DSQSQSQTQS QSASQSESNA SSQFQAQEQS NRLLENPPVS ESQSQSESQS 

       250        260        270        280        290        300 
QSESQKQSQS QSQRQQQIQT QLQILRQLQQ KSNEQSAAQS ASQIQSQRQS DSQSNLQLQE 

       310        320        330        340        350        360 
QSQSQSEQGK PIQSQIQILQ GLQQKELDDK SASQSQSESK TRQEQQKQLN LQQLEELSSS 

       370        380        390        400        410        420 
LSQSRLGLGQ QIQSQLQKNQ LDKQFASQFQ SQSKSQLEQQ MQLQLQSLRQ LQQKQLDEQS 

       430        440        450        460        470        480 
ASQSQPQSQV AQQIQSHLQL LRLLQSRLKT QSALKSDLEQ QILLQLKKLT EVQQKQLAEQ 

       490        500        510        520        530        540 
PTLRPSSKSQ SPGQLEQQIL LQLQNLLQFQ QNQLKSDTQT QSQLQESKSN SLSQSQSQSQ 

       550        560        570        580        590        600 
EQLQLQRDQN LRQLEQIKLE MQNIRELLQK GKSELQTQSD SQRRIHELYQ NILQLNKEKL 

       610        620        630        640        650        660 
SYQLKQLKLK ELEDQKKSQA EISKGSNPSN LFIIGQLPSE GKPAPGNQGP SIEPKLVPQP 

       670        680        690        700        710        720 
GSLDKLPSGG GLIGKPASTG LYILSPDFND LSDYRDQFRL QQELKKHQNI LSLLQRRQND 

       730        740        750        760        770        780 
IKKQQNAQLL LGQQQKEQQA QESINKQQSS SAGSSSQTKL QQDIQSTGAQ GSQQGLQAGS 

       790        800        810        820        830        840 
TGLQTSSLQG TESSASQSAA LQRLKEQEQL RIQTENDQKT SSSSSHSNSQ NSQSSSSQSS 

       850        860        870        880        890        900 
QASQSEAQRQ EAGNRNTLLL DQSSSKTQSE SKSESSSQSS SHSSSQSTSN SSSNVQSKLQ 

       910 
GESQALLNNL SG

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References

« Hide 'large scale' references
[1]"New genes for male accessory gland proteins in Drosophila melanogaster."
Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.
Insect Biochem. Mol. Biol. 27:825-834(1997) [PubMed: 9474779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
Strain: Canton-S.
Tissue: Male accessory gland.
[2]Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO N-TERMINUS AND C-TERMINUS.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[6]"Molecular population genetics of male accessory gland proteins in Drosophila."
Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G.
Genetics 156:1879-1888(2000) [PubMed: 11102381] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 144-889.
Strain: SENGWA2, SENGWA22, SENGWA29, SENGWA30, SENGWA32, SENGWA37, SENGWA51, WSII1, WSII12, WSII16, WSII19, WSII26, WSII47, WSII49, WSII6 and WSII9.
[7]"A Drosophila complementary DNA resource."
Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M., Harvey D.A.
Science 287:2222-2224(2000) [PubMed: 10731138] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 401-912.
Strain: Berkeley.
Tissue: Head.
[8]"An early role for the Drosophila melanogaster male seminal protein Acp36DE in female sperm storage."
Bloch-Qazi M.C., Wolfner M.F.
J. Exp. Biol. 206:3521-3528(2003) [PubMed: 12939382] [Abstract]
Cited for: FUNCTION.

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Cross-references

Sequence databases

U85759 mRNA. Translation: AAB96383.2.
AF157488 Genomic DNA. Translation: AAD40185.1.
AE014134 Genomic DNA. Translation: AAF53664.1.
AY113344 mRNA. Translation: AAM29349.1.
AY010577 Genomic DNA. Translation: AAG37359.1.
AY010578 Genomic DNA. Translation: AAG37360.1.
AY010579 Genomic DNA. Translation: AAG37361.1.
AY010580 Genomic DNA. Translation: AAG37362.1.
AY010581 Genomic DNA. Translation: AAG37363.1.
AY010582 Genomic DNA. Translation: AAG37364.1.
AY010583 Genomic DNA. Translation: AAG37365.1.
AY010584 Genomic DNA. Translation: AAG37366.1.
AY010585 Genomic DNA. Translation: AAG37367.1.
AY010586 Genomic DNA. Translation: AAG37368.1.
AY010587 Genomic DNA. Translation: AAG37369.1.
AY010588 Genomic DNA. Translation: AAG37370.1.
AY010589 Genomic DNA. Translation: AAG37371.1.
AY010590 Genomic DNA. Translation: AAG37372.1.
AY010591 Genomic DNA. Translation: AAG37373.1.
AY010592 Genomic DNA. Translation: AAG37374.1.
AF145666 mRNA. Translation: AAD38641.1.
RefSeqNP_523594.1.
UniGeneDm.29426

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:24017N.
IntActQ9V3R1. 1 interaction.

Proteomic databases

PRIDEQ9V3R1.

Genome annotation databases

EnsemblFBgn0011559. Drosophila melanogaster. [Contig view]
GeneID35096.
KEGGdme:Dmel_CG7157.
NMPDRfig|7227.3.peg.2822.

Organism-specific databases

FlyBaseFBgn0011559. Acp36DE.

Phylogenomic databases

HOGENOMQ9V3R1.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-009343-MON.

Gene expression databases

ArrayExpressQ9V3R1.
GermOnlineCG7157. Drosophila melanogaster.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio791836.

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Entry information

Entry nameA36DE_DROME
AccessionPrimary (citable) accession number: Q9V3R1
Secondary accession number(s): O46198, Q9U9Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents