Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

26S proteasome non-ATPase regulatory subunit 1

Gene

Rpn2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.1 Publication

GO - Molecular functioni

  • enzyme regulator activity Source: InterPro
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • regulation of protein catabolic process Source: InterPro

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 1
Alternative name(s):
26S proteasome regulatory complex subunit p110
26S proteasome regulatory subunit RPN2
Gene namesi
Name:Rpn2
ORF Names:CG11888
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028692 Rpn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738041 – 102026S proteasome non-ATPase regulatory subunit 1Add BLAST1020

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291Phosphothreonine1 Publication1
Modified residuei298Phosphoserine1 Publication1
Modified residuei303Phosphoserine1 Publication1
Modified residuei305Phosphoserine1 Publication1
Modified residuei310Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V3P6
PRIDEiQ9V3P6

PTM databases

iPTMnetiQ9V3P6

Expressioni

Gene expression databases

BgeeiFBgn0028692
ExpressionAtlasiQ9V3P6 baseline and differential
GenevisibleiQ9V3P6 DM

Interactioni

Protein-protein interaction databases

BioGridi68320, 39 interactors
IntActiQ9V3P6, 6 interactors
STRINGi7227.FBpp0303405

Structurei

3D structure databases

ProteinModelPortaliQ9V3P6
SMRiQ9V3P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati418 – 452PC 1Add BLAST35
Repeati456 – 489PC 2Add BLAST34
Repeati491 – 525PC 3Add BLAST35
Repeati526 – 560PC 4Add BLAST35
Repeati562 – 595PC 5Add BLAST34
Repeati596 – 631PC 6Add BLAST36
Repeati632 – 664PC 7Add BLAST33
Repeati666 – 701PC 8Add BLAST36
Repeati702 – 742PC 9Add BLAST41
Repeati745 – 777PC 10Add BLAST33

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2062 Eukaryota
COG5116 LUCA
GeneTreeiENSGT00550000074915
InParanoidiQ9V3P6
KOiK03032
OMAiRNCTIGL
OrthoDBiEOG091G01IW
PhylomeDBiQ9V3P6

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016642 26S_Psome_Rpn2
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
IPR035266 PSMD1
PANTHERiPTHR10943:SF2 PTHR10943:SF2, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 3 hits
PIRSFiPIRSF015947 26S_Psome_Rpn2, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9V3P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLTSAAGII SLLDEPMPDL KVFALKKLDN IVDEFWPEIS ESIEKIEMLH
60 70 80 90 100
EDRSFPENKL AGMVASKVFY HLGSFEDALT YALGAGDLFD VNARNEYTET
110 120 130 140 150
IIAKCIDFYI AQRVEFIENP KEASVVDERL EGIVNRMIQR CLDDNQFRQA
160 170 180 190 200
LGIALETRRM DTFKDAIMKS DDVRGMLAYA YNVTMSLIQN RGFRNEVLRC
210 220 230 240 250
LVSLYRDLGV PDYVNMCQCL IFLEDPFAVA EMLDNLTRSS VETNNLMAYQ
260 270 280 290 300
IAFDLYESAT QEFLGNVLQH LKNTAPIPTA LPSTFKPQGT TSEDGAKSEG
310 320 330 340 350
DKSKSDEDIT EETPADDKVE RTIDSLNEVE KLHQKNIEKL ISILSGEVSI
360 370 380 390 400
DLQLQFLIRS NHADLQVLRG TKEAVRVSIC HTATVIANAF MHSGTTSDQF
410 420 430 440 450
LRDNLDWLAR ATNWAKLTAT ASLGVIHRGH EKDSLALMQS YLPKEAGPSS
460 470 480 490 500
GYSEGGALYA LGLIHANHGA NIIDYLLQQL KDAQNENVRH GGCLGLGLAG
510 520 530 540 550
MGTHRQDLYE QLKFNLYQDD AVTGEAAGIA MGMVMLGSKN AQAIEDMVSY
560 570 580 590 600
AQETQHEKIL RGLAVGISLT MFSRLEEADP LVTSLSSDKD PVLRRSGMYT
610 620 630 640 650
IAMAYNGTGS NKAIRKLLHV AVSDVNDDVR RAAVTAIGFI LFRSPEQCPS
660 670 680 690 700
VVSLLAESYN PHVRYGAAMA LGIACAGTGL REAIALLEPM VKFDPVNFVR
710 720 730 740 750
QGALIASAMI LIQHTDQSCP KSTFFRQLYA EVISNKHEDV MAKYGAILAQ
760 770 780 790 800
GIIDAGGRNA TLSLQSRTGH TNLQAVVGML AFTQYWYWFP LAHTLSLAFT
810 820 830 840 850
PTCVIGLNSD LKMPKMEYKS AAKPSLYAYP APLEEKKSEE REKVATAVLS
860 870 880 890 900
IAARQKRREN ADKKEDEKMD VDEDSKEGAA VKKDEEAKAD EKMVTDEKPK
910 920 930 940 950
KKDEKEKKKE EDKEKEAAGT SSEKDKDKEK DKKEKKEPEP TSEILQNPAR
960 970 980 990 1000
VLRQQLKVLS VIDGQSYEPL KDVTIGGIIV FQHTGKAEDQ ELVEPVAAFG
1010 1020
PMNDEEKEPE PPEPFEYIED
Length:1,020
Mass (Da):113,199
Last modified:May 1, 2000 - v1
Checksum:i8DE7AA5264742EB1
GO
Isoform B (identifier: Q9V3P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-114: Missing.

Show »
Length:946
Mass (Da):104,810
Checksum:iD8C651BB1188974D
GO

Sequence cautioni

The sequence AAL39648 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti646E → G in AAN71353 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01161141 – 114Missing in isoform B. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145303 mRNA Translation: AAF08384.1
AF186594 Genomic DNA Translation: AAG16726.2
AF312231 mRNA Translation: AAG33625.1
AE014297 Genomic DNA Translation: AAF56868.1
AY069503 mRNA Translation: AAL39648.1 Different initiation.
BT001598 mRNA Translation: AAN71353.1
BT044102 mRNA Translation: ACH92167.1
RefSeqiNP_001263058.1, NM_001276129.1 [Q9V3P6-1]
NP_651677.2, NM_143420.3 [Q9V3P6-1]
UniGeneiDm.6875

Genome annotation databases

EnsemblMetazoaiFBtr0085385; FBpp0084754; FBgn0028692 [Q9V3P6-1]
FBtr0334532; FBpp0306599; FBgn0028692 [Q9V3P6-1]
GeneIDi43449
KEGGidme:Dmel_CG11888
UCSCiCG11888-RA d. melanogaster [Q9V3P6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPSMD1_DROME
AccessioniPrimary (citable) accession number: Q9V3P6
Secondary accession number(s): B5RIH8
, Q8IGU4, Q8T075, Q9GSE5, Q9GU70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health