Q9V3N4 (Q9V3N4_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Huntingtin EMBL AAF56808.1

Submitted name:
Huntington disease protein homolog EMBL AAF03255.1

Gene names

Name:	htt FlyBase FBgn0027655
Synonyms:	Hsap\HD EMBL AAF03255.1, huntingtin FlyBase FBgn0027655
ORF Names:	CG9995 FlyBase FBgn0027655, Dmel_CG9995 EMBL AAF56808.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	3583 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	establishment of mitotic spindle orientation Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9V3N4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 98C83978C4F0A888	FASTA	3,583	395,867
	10 20 30 40 50 60 MDKSRSSAYD KFVGFVEQLR NTECSQKQKI TCFQQIAECI MSPSLAGHIN YAAHCGTATN 70 80 90 100 110 120 VLLLFCEDVD SVVRMSAEEN LNKILRSLEK TRVSRILMDL YGEIKRNGNQ RSLRICLNLF 130 140 150 160 170 180 SYYAPQIKEK HIKWYAVRLL QCMTTISQRK ETLLQETLCD FVKHFSRHIQ QGLSDSESCK 190 200 210 220 230 240 LFETFLDQIS SDCAVKRRCS AQNCMSLIEN ARNRSLMARH GVNKVMELLL TDQQANSVLG 250 260 270 280 290 300 ALGLLRLLLP QLIRGYPGDS HEDSESLAGK KQQQQQTTTS DCRQIIEIYD YCLHLLSTQH 310 320 330 340 350 360 TANHAIINAT LEVINGILQA VDAASDGQCS QSLGQSLRQL LCNQQLQHNE YLRRRKSLKN 370 380 390 400 410 420 QIFQLKNYEV ATSQHQLEDE DENEDVDELV VGATAMQMKK NSNAKLQQAK CREQQQHQHQ 430 440 450 460 470 480 QQLEVDNSSL GINAGEDAPT EAPSSVADEG GEPESTKLRC HIRNAARSIS ECVASDEDKQ 490 500 510 520 530 540 GQGHRQQRDE DGVVVAEDDD DDDDDDDDDD DMELLSAECD DFTTLSQLNE QQQALSAALK 550 560 570 580 590 600 LPTTTAASSG GAATSQDDKL IDVDADVGGL PKPQHQSSLQ NLLAGSDDKS QHLSDIDNES 610 620 630 640 650 660 FNSIDFDAEI TIAGSKEQQQ QHPPADDSVE SGDATAIGTF FNNLLSHSNA ASESVSKLFR 670 680 690 700 710 720 QSSGSKSTPS KSASTPAPAD KSDAISAASL TLSLTSLASS NLEPPERQPL IAETPTPVED 730 740 750 760 770 780 SCSITASHTA STALMMDAPA VEVAASKPET PQLRGTPNAN PFLVENSPLR QTVVGRALIT 790 800 810 820 830 840 VKIGSILEQS LVYYTARLVA ARFLLSGQAA GLQPDSISRV SIKSLSLAVI AQCVRLAPKI 850 860 870 880 890 900 LQLSLEISEQ ELQLLEEATS QIGSGDSTQV SSPQSSDNSQ VGGEKPPLDS SLVPTSLEEN 910 920 930 940 950 960 LLLLDIKDDH FGPSTCPAYL QSATPTLSRS ADASVLLLEG GTTSSRSAKK SEEMLSKSEI 970 980 990 1000 1010 1020 IESSYRPTVA VEDVPPLSMP PRPPKRTKST RSRVGVLGTS STTESSSPQS RQKLSDILLF 1030 1040 1050 1060 1070 1080 HDHCDPILRG GVQQVVGNFL QSSGAGLFLD LQRGLGLQHL LAILLKGFED EIHTVVIQAL 1090 1100 1110 1120 1130 1140 NAFDKIFPNV VSKYLTEPPC HYHAHQQQQQ QQKEQQQQEQ DNQKLEQDLQ RHSSGQQKRS 1150 1160 1170 1180 1190 1200 GQAQTFGQQT FAKDQDNALS SQRQQQRRPN DAGTCANSSA TDNDELLAAL LNDFQLQSTG 1210 1220 1230 1240 1250 1260 MRQQPKNNST DTGQSGNEPD LEPNPNAAVE PFCVFAISPK LLLSKLRLCH HNKYWLVQNK 1270 1280 1290 1300 1310 1320 YAEVISNLNY VLLRSYYANF RCAIDNKNSG ARKQDSKWPP MDASSVCHSV RDAEGEDIVC 1330 1340 1350 1360 1370 1380 TYEAQFLAEL LHLLGDDDAR VREHAACCLC RFIMQTARQD PSQDQGAGGG GGDDIEGNGN 1390 1400 1410 1420 1430 1440 VNVETQQTNF NLLWDFFDYR IFGSMSVTLR NLFRASSTIV PPLAELDALA TSNSAPSYPD 1450 1460 1470 1480 1490 1500 TGSTSGSSTS TSASSGGSAA AVSAASAYFE ASYGIGIAEG HVFALASASQ RQIAQEEKVL 1510 1520 1530 1540 1550 1560 AKVLYRLTNK LMTLNDKNVQ FGIIYALRLL LRHFNFVDYQ QVWLEFNFVE ICISYAYYNN 1570 1580 1590 1600 1610 1620 ATAADLGCQN DLIDVMGKLM AGAMLSSGEP NTAHLDFLLR HSVKMLNIYY HLVTNQRPPT 1630 1640 1650 1660 1670 1680 AGSQSGSSSS KQPKSELFAR EQPAATLQAL GYFAGDYVYM KLYNILRGAN DSYKITINQE 1690 1700 1710 1720 1730 1740 AGSLLICLLK TCLHAVSLCL EGMASASPPE LKLIEEILHY LTRLINYAPA ECVACLRQLL 1750 1760 1770 1780 1790 1800 KYLFAQNYAS QVRLQPSAIG GNGSEIGHHA AFMRPYFAAK GRGHGASSTL LPTINSKPAV 1810 1820 1830 1840 1850 1860 AVGSQRGAPT DARQPIDAGP LQDMGMLFVH GLQPPTPPAG DCVRLIKLFE PMVIYCLTLF 1870 1880 1890 1900 1910 1920 MKSNALVQAP ILRLLSQLLD LNVTYSILDS KNVIFDQVLS NMDLIEGGID RNAFIMVPPM 1930 1940 1950 1960 1970 1980 LRFLVQLTHK SDRQLITIPK IISITNNLLA NGSVRVVALL ALKTLSYELF FMHSQLEEAL 1990 2000 2010 2020 2030 2040 DTEGHNSGRD ACQSPLSAAP TPETREALLA QRRELDTQRE VVLGMLEKFI EARPSQQVLA 2050 2060 2070 2080 2090 2100 LLLLFERSVQ QLDTPPYRSA QDADAVYGTL CRGLCSRQWR LHNAGDLRLL ESCFRNNGNH 2110 2120 2130 2140 2150 2160 VLADSKRFLQ LLQLFIEQGV GNFGDLALAM VMLSNVILKT EEIYLVNHIK LYLKNNPTAE 2170 2180 2190 2200 2210 2220 RRLQALMPSS PSAAPHWQDE APSTSSAAAA ARAAAASFSA GRSSISEINY FAKVLCEKLL 2230 2240 2250 2260 2270 2280 ACLEVLLGLE PSSSSHAYCQ LTGRFMDALL NVCCRSRHKD ALQSVFRLVL AESEFLCKYY 2290 2300 2310 2320 2330 2340 SLLLMSAAGL VGSYLLDAVL LACLRLVLAM RLEEPVALLE QAAQLPLKTN LQRALLREVC 2350 2360 2370 2380 2390 2400 RASAGCDWSA QQVRRLFEGR YLNFLIADHL EFICELCQER PECGSLLQVA LFRNAHRLSR 2410 2420 2430 2440 2450 2460 QSVRIVLRLL GRLCEPAERE ASGDVGSDAD PTLQAMQLLS RLHQLYEGER SLQLPIERMA 2470 2480 2490 2500 2510 2520 RRLSAQSGQP ARNVIYERLV EGDLAGGEDQ DALRTLLLKD LECRQDNETA TPSRIIDESW 2530 2540 2550 2560 2570 2580 LFAQLIKFAT QHADAPQQQK QLMLLLLEIQ SEPKLQRLLR SLGTEHEAKL LRHAIAGSLA 2590 2600 2610 2620 2630 2640 AMMSAFRQKC IQHAPHINYM QPTPLARVSC ALLMSRVAST EATKCRNPPT GEQLDVARAV 2650 2660 2670 2680 2690 2700 GALMACIRNA EQTALIYIDA RLMEKFVVEH LLRREHLPQL LAYLGWLAGA AKQILAMPTR 2710 2720 2730 2740 2750 2760 QESEQDALGV LLATVNTLLQ QPRVWRELNA SSDPSLRCEL LDLLDSVARC ILQDTIFYRR 2770 2780 2790 2800 2810 2820 HRRDRNKAKG PAPQAIFLAK LIETQIEIES LASGRVLAGV EEARLQFAGQ DLARFQVALS 2830 2840 2850 2860 2870 2880 LVTSIGISLL RTHQFYAYAV TPHELIQQPG DQQQEQQADG KLPSIPVDSL SDVDVLRQFV 2890 2900 2910 2920 2930 2940 KRLSIFGFTT RQQFEEYFMT CLLLINKLYD EHMVDQQEQF QIKQVCLQAI LELLMTYKTF 2950 2960 2970 2980 2990 3000 PIVGLANGQF HHTTRWQRIT CDSISLKKLH KVQLLVDACN VFYQPNLERQ LAYDNVIGTR 3010 3020 3030 3040 3050 3060 TFAPNQYDLN FSWAQMEDQA AAGVGVGVGV GLSGGEQANT ADIKQSCDAD VPDMAMRNYR 3070 3080 3090 3100 3110 3120 HFTQLSGIDF RSSTQLVFDV LQQMIELNHI LVLPNLVKFC EICESRDHIK WIKERCLKLQ 3130 3140 3150 3160 3170 3180 EQVAMDDTIS HQHIIYLLCR SQALLIPSLG ELQVLCSLIG NVYLKSTHSF IRIATLQGLL 3190 3200 3210 3220 3230 3240 CLLECCSKTN TTMGRLSEEL ALLRSLIVGY INRHGIIDES PLPFSVEHTK LVWTLNYSLI 3250 3260 3270 3280 3290 3300 EWTSKFVPQC HLLSNTIIAA NNFLKTTADE ELYLCVLHGL ERMVVNSGVP PPGIQPTGKD 3310 3320 3330 3340 3350 3360 AAAGEPGAEG SKAGVGVVVT PQMRHKIEKL ALELLKMENE KFSIPALKLL LSCMYVGSAA 3370 3380 3390 3400 3410 3420 QLENTELSNG IVQDDPEIIA QQNDKVDILL HCIKSSTRDA AWIYGQVLCQ IIRDLVPPNE 3430 3440 3450 3460 3470 3480 ILTKVIKEFL AINHPHCDVI AMIVYQVFRS AIDSSYLQML QDWLICTLPT FLDQPEQQGV 3490 3500 3510 3520 3530 3540 WGLSVIFLSA SINLHLIKLF PLVLGIGASN SAAAATTATT ATTEAEAAAP AMARKLGQHE 3550 3560 3570 3580 IALFVTAAQD FHAKLSGEQR QRFREAFGSF KRSQVYGRML QCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"A putative Drosophila homolog of the Huntington's disease gene." Li Z., Karlovich C.A., Fish M.P., Scott M.P., Myers R.M. Hum. Mol. Genet. 8:1807-1815(1999) [PubMed: 10441347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF146362 mRNA. Translation: AAF03255.1. AF147779 Genomic DNA. Translation: AAF03256.1. AE014297 Genomic DNA. Translation: AAF56808.1.
RefSeq	NP_651629.1. NM_143372.1.
UniGene	Dm.1357.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9V3N4.
Proteomic databases
PRIDE	Q9V3N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085310; FBpp0084679; FBgn0027655.
GeneID	43392.
KEGG	dme:Dmel_CG9995.
NMPDR	fig|7227.3.peg.15114.
UCSC	CG9995-RA. d. melanogaster.
Organism-specific databases
CTD	3064.
FlyBase	FBgn0027655. htt.
Phylogenomic databases
GeneTree	EMGT00050000010324.
InParanoid	Q9V3N4.
OMA	KFCEICE.
PhylomeDB	Q9V3N4.
Gene expression databases
ArrayExpress	Q9V3N4.
Bgee	Q9V3N4.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000357. HEAT. IPR000091. Huntingtin. IPR024613. Huntingtin_middle-repeat. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 5 hits.
KO	K04533.
PANTHER	PTHR10170. Huntingtin. 1 hit.
Pfam	PF12372. DUF3652. 2 hits. PF02985. HEAT. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	833691.

Entry information

Entry name

Q9V3N4_DROME

Accession

Primary (citable) accession number: Q9V3N4

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)