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Protein

Protein will die slowly

Gene

wds

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity).By similarity

GO - Biological processi

  • chromatin remodeling Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone H3-K4 methylation Source: FlyBase
  • mitotic G2 DNA damage checkpoint Source: FlyBase
  • neurogenesis Source: FlyBase
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-3214841. PKMTs methylate histone lysines.
R-DME-3214847. HATs acetylate histones.
R-DME-3214858. RMTs methylate histone arginines.
SignaLinkiQ9V3J8.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein will die slowly
Gene namesi
Name:wds
Synonyms:l(1)3Ad, l(1)zw8
ORF Names:CG17437
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0040066. wds.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • MLL1/2 complex Source: FlyBase
  • MLL3/4 complex Source: FlyBase
  • NSL complex Source: FlyBase
  • nucleus Source: FlyBase
  • Set1C/COMPASS complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Larval lethal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Protein will die slowlyPRO_0000051433Add
BLAST

Proteomic databases

PaxDbiQ9V3J8.
PRIDEiQ9V3J8.

Expressioni

Tissue specificityi

Expressed in imaginal disks, larval brain, nurse cells, spermatogonia and spermatocytes.1 Publication

Developmental stagei

Expressed at all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0040066.
ExpressionAtlasiQ9V3J8. differential.
GenevisibleiQ9V3J8. DM.

Interactioni

Subunit structurei

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Interacts with Set1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
dgt1Q9VAF45EBI-90899,EBI-120581
nsl1A4V2Z18EBI-90899,EBI-9630827

Protein-protein interaction databases

BioGridi72718. 15 interactions.
IntActiQ9V3J8. 9 interactions.
MINTiMINT-8211308.
STRINGi7227.FBpp0300790.

Structurei

Secondary structure

1
361
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi63 – 686Combined sources
Beta strandi75 – 806Combined sources
Beta strandi84 – 918Combined sources
Beta strandi96 – 1005Combined sources
Turni101 – 1033Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi117 – 1226Combined sources
Beta strandi126 – 1338Combined sources
Beta strandi136 – 1427Combined sources
Turni143 – 1453Combined sources
Beta strandi148 – 1536Combined sources
Beta strandi159 – 1646Combined sources
Beta strandi168 – 1758Combined sources
Beta strandi180 – 1845Combined sources
Turni185 – 1873Combined sources
Beta strandi190 – 1945Combined sources
Beta strandi201 – 2066Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi222 – 2265Combined sources
Turni227 – 2293Combined sources
Beta strandi232 – 2365Combined sources
Beta strandi244 – 2496Combined sources
Beta strandi256 – 2605Combined sources
Turni261 – 2633Combined sources
Beta strandi264 – 2696Combined sources
Turni270 – 2734Combined sources
Beta strandi274 – 2796Combined sources
Beta strandi285 – 2873Combined sources
Beta strandi291 – 2944Combined sources
Beta strandi296 – 2983Combined sources
Beta strandi300 – 3034Combined sources
Beta strandi310 – 3145Combined sources
Turni315 – 3173Combined sources
Beta strandi320 – 3245Combined sources
Beta strandi331 – 3366Combined sources
Beta strandi338 – 34710Combined sources
Turni349 – 3513Combined sources
Beta strandi354 – 3585Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CY3X-ray1.40A50-361[»]
4CY5X-ray2.30A50-361[»]
ProteinModelPortaliQ9V3J8.
SMRiQ9V3J8. Positions 26-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 10039WD 1Add
BLAST
Repeati104 – 14239WD 2Add
BLAST
Repeati146 – 18439WD 3Add
BLAST
Repeati188 – 22639WD 4Add
BLAST
Repeati230 – 26940WD 5Add
BLAST
Repeati273 – 31442WD 6Add
BLAST
Repeati318 – 35841WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
InParanoidiQ9V3J8.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ9V3J8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V3J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPIGAVHGG HPGVVHPPQQ PLPTAPSGPN SLQPNSVGQP GATTSSNSSA
60 70 80 90 100
SNKSSLSVKP NYTLKFTLAG HTKAVSAVKF SPNGEWLASS SADKLIKIWG
110 120 130 140 150
AYDGKFEKTI SGHKLGISDV AWSSDSRLLV SGSDDKTLKV WELSTGKSLK
160 170 180 190 200
TLKGHSNYVF CCNFNPQSNL IVSGSFDESV RIWDVRTGKC LKTLPAHSDP
210 220 230 240 250
VSAVHFNRDG SLIVSSSYDG LCRIWDTASG QCLKTLIDDD NPPVSFVKFS
260 270 280 290 300
PNGKYILAAT LDNTLKLWDY SKGKCLKTYT GHKNEKYCIF ANFSVTGGKW
310 320 330 340 350
IVSGSEDNMV YIWNLQSKEV VQKLQGHTDT VLCTACHPTE NIIASAALEN
360
DKTIKLWKSD T
Length:361
Mass (Da):39,041
Last modified:May 1, 2000 - v1
Checksum:iB2A64127F1E0292D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233288 Genomic DNA. Translation: AAF43418.1.
AE014298 Genomic DNA. Translation: AAF45791.1.
AL138972 Genomic DNA. Translation: CAB72292.1.
AY118386 mRNA. Translation: AAM48415.1.
RefSeqiNP_001245503.1. NM_001258574.2.
NP_524984.1. NM_080245.5.
UniGeneiDm.7137.

Genome annotation databases

EnsemblMetazoaiFBtr0070438; FBpp0070422; FBgn0040066.
FBtr0308566; FBpp0300790; FBgn0040066.
GeneIDi53428.
KEGGidme:Dmel_CG17437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233288 Genomic DNA. Translation: AAF43418.1.
AE014298 Genomic DNA. Translation: AAF45791.1.
AL138972 Genomic DNA. Translation: CAB72292.1.
AY118386 mRNA. Translation: AAM48415.1.
RefSeqiNP_001245503.1. NM_001258574.2.
NP_524984.1. NM_080245.5.
UniGeneiDm.7137.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CY3X-ray1.40A50-361[»]
4CY5X-ray2.30A50-361[»]
ProteinModelPortaliQ9V3J8.
SMRiQ9V3J8. Positions 26-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi72718. 15 interactions.
IntActiQ9V3J8. 9 interactions.
MINTiMINT-8211308.
STRINGi7227.FBpp0300790.

Proteomic databases

PaxDbiQ9V3J8.
PRIDEiQ9V3J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070438; FBpp0070422; FBgn0040066.
FBtr0308566; FBpp0300790; FBgn0040066.
GeneIDi53428.
KEGGidme:Dmel_CG17437.

Organism-specific databases

CTDi53428.
FlyBaseiFBgn0040066. wds.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
InParanoidiQ9V3J8.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ9V3J8.

Enzyme and pathway databases

ReactomeiR-DME-3214841. PKMTs methylate histone lysines.
R-DME-3214847. HATs acetylate histones.
R-DME-3214858. RMTs methylate histone arginines.
SignaLinkiQ9V3J8.

Miscellaneous databases

ChiTaRSiwds. fly.
GenomeRNAii53428.
PROiQ9V3J8.

Gene expression databases

BgeeiFBgn0040066.
ExpressionAtlasiQ9V3J8. differential.
GenevisibleiQ9V3J8. DM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDS_DROME
AccessioniPrimary (citable) accession number: Q9V3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.