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Protein

Protein will die slowly

Gene

wds

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity).By similarity

GO - Biological processi

  • chromatin remodeling Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone H3-K4 methylation Source: FlyBase
  • mitotic G2 DNA damage checkpoint Source: FlyBase
  • neurogenesis Source: FlyBase
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-3214847. HATs acetylate histones.
SignaLinkiQ9V3J8.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein will die slowly
Gene namesi
Name:wds
Synonyms:l(1)3Ad, l(1)zw8
ORF Names:CG17437
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0040066. wds.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • MLL1/2 complex Source: FlyBase
  • MLL3/4 complex Source: FlyBase
  • NSL complex Source: FlyBase
  • nucleus Source: FlyBase
  • Set1C/COMPASS complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Larval lethal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514331 – 361Protein will die slowlyAdd BLAST361

Proteomic databases

PaxDbiQ9V3J8.
PRIDEiQ9V3J8.

Expressioni

Tissue specificityi

Expressed in imaginal disks, larval brain, nurse cells, spermatogonia and spermatocytes.1 Publication

Developmental stagei

Expressed at all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0040066.
ExpressionAtlasiQ9V3J8. baseline.
GenevisibleiQ9V3J8. DM.

Interactioni

Subunit structurei

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Interacts with Set1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
dgt1Q9VAF45EBI-90899,EBI-120581
nsl1A4V2Z18EBI-90899,EBI-9630827

Protein-protein interaction databases

BioGridi72718. 15 interactors.
IntActiQ9V3J8. 9 interactors.
MINTiMINT-8211308.
STRINGi7227.FBpp0300790.

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi63 – 68Combined sources6
Beta strandi75 – 80Combined sources6
Beta strandi84 – 91Combined sources8
Beta strandi96 – 100Combined sources5
Turni101 – 103Combined sources3
Beta strandi106 – 110Combined sources5
Beta strandi117 – 122Combined sources6
Beta strandi126 – 133Combined sources8
Beta strandi136 – 142Combined sources7
Turni143 – 145Combined sources3
Beta strandi148 – 153Combined sources6
Beta strandi159 – 164Combined sources6
Beta strandi168 – 175Combined sources8
Beta strandi180 – 184Combined sources5
Turni185 – 187Combined sources3
Beta strandi190 – 194Combined sources5
Beta strandi201 – 206Combined sources6
Beta strandi210 – 217Combined sources8
Beta strandi222 – 226Combined sources5
Turni227 – 229Combined sources3
Beta strandi232 – 236Combined sources5
Beta strandi244 – 249Combined sources6
Beta strandi256 – 260Combined sources5
Turni261 – 263Combined sources3
Beta strandi264 – 269Combined sources6
Turni270 – 273Combined sources4
Beta strandi274 – 279Combined sources6
Beta strandi285 – 287Combined sources3
Beta strandi291 – 294Combined sources4
Beta strandi296 – 298Combined sources3
Beta strandi300 – 303Combined sources4
Beta strandi310 – 314Combined sources5
Turni315 – 317Combined sources3
Beta strandi320 – 324Combined sources5
Beta strandi331 – 336Combined sources6
Beta strandi338 – 347Combined sources10
Turni349 – 351Combined sources3
Beta strandi354 – 358Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CY3X-ray1.40A50-361[»]
4CY5X-ray2.30A50-361[»]
ProteinModelPortaliQ9V3J8.
SMRiQ9V3J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 100WD 1Add BLAST39
Repeati104 – 142WD 2Add BLAST39
Repeati146 – 184WD 3Add BLAST39
Repeati188 – 226WD 4Add BLAST39
Repeati230 – 269WD 5Add BLAST40
Repeati273 – 314WD 6Add BLAST42
Repeati318 – 358WD 7Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
InParanoidiQ9V3J8.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ9V3J8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V3J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPIGAVHGG HPGVVHPPQQ PLPTAPSGPN SLQPNSVGQP GATTSSNSSA
60 70 80 90 100
SNKSSLSVKP NYTLKFTLAG HTKAVSAVKF SPNGEWLASS SADKLIKIWG
110 120 130 140 150
AYDGKFEKTI SGHKLGISDV AWSSDSRLLV SGSDDKTLKV WELSTGKSLK
160 170 180 190 200
TLKGHSNYVF CCNFNPQSNL IVSGSFDESV RIWDVRTGKC LKTLPAHSDP
210 220 230 240 250
VSAVHFNRDG SLIVSSSYDG LCRIWDTASG QCLKTLIDDD NPPVSFVKFS
260 270 280 290 300
PNGKYILAAT LDNTLKLWDY SKGKCLKTYT GHKNEKYCIF ANFSVTGGKW
310 320 330 340 350
IVSGSEDNMV YIWNLQSKEV VQKLQGHTDT VLCTACHPTE NIIASAALEN
360
DKTIKLWKSD T
Length:361
Mass (Da):39,041
Last modified:May 1, 2000 - v1
Checksum:iB2A64127F1E0292D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233288 Genomic DNA. Translation: AAF43418.1.
AE014298 Genomic DNA. Translation: AAF45791.1.
AL138972 Genomic DNA. Translation: CAB72292.1.
AY118386 mRNA. Translation: AAM48415.1.
RefSeqiNP_001245503.1. NM_001258574.2.
NP_524984.1. NM_080245.5.
UniGeneiDm.7137.

Genome annotation databases

EnsemblMetazoaiFBtr0070438; FBpp0070422; FBgn0040066.
FBtr0308566; FBpp0300790; FBgn0040066.
GeneIDi53428.
KEGGidme:Dmel_CG17437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233288 Genomic DNA. Translation: AAF43418.1.
AE014298 Genomic DNA. Translation: AAF45791.1.
AL138972 Genomic DNA. Translation: CAB72292.1.
AY118386 mRNA. Translation: AAM48415.1.
RefSeqiNP_001245503.1. NM_001258574.2.
NP_524984.1. NM_080245.5.
UniGeneiDm.7137.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CY3X-ray1.40A50-361[»]
4CY5X-ray2.30A50-361[»]
ProteinModelPortaliQ9V3J8.
SMRiQ9V3J8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi72718. 15 interactors.
IntActiQ9V3J8. 9 interactors.
MINTiMINT-8211308.
STRINGi7227.FBpp0300790.

Proteomic databases

PaxDbiQ9V3J8.
PRIDEiQ9V3J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070438; FBpp0070422; FBgn0040066.
FBtr0308566; FBpp0300790; FBgn0040066.
GeneIDi53428.
KEGGidme:Dmel_CG17437.

Organism-specific databases

CTDi53428.
FlyBaseiFBgn0040066. wds.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00810000125363.
InParanoidiQ9V3J8.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG091G0CM2.
PhylomeDBiQ9V3J8.

Enzyme and pathway databases

ReactomeiR-DME-3214847. HATs acetylate histones.
SignaLinkiQ9V3J8.

Miscellaneous databases

ChiTaRSiwds. fly.
GenomeRNAii53428.
PROiQ9V3J8.

Gene expression databases

BgeeiFBgn0040066.
ExpressionAtlasiQ9V3J8. baseline.
GenevisibleiQ9V3J8. DM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDS_DROME
AccessioniPrimary (citable) accession number: Q9V3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.