Q9V3J6 (Q9V3J6_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bestrophin 1 EMBL AAR99659.1

Submitted name:
Bestrophin 1, isoform A EMBL AAF54503.1
Submitted name:
Dbest EMBL AAF32327.1
Submitted name:
LP05915p EMBL AAL29094.1

Gene names

Name:	Best1 FlyBase FBgn0040238 EMBL AAF54503.1
ORF Names:	CG6264 FlyBase FBgn0040238, Dmel_CG6264 EMBL AAF54503.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell volume homeostasis Inferred from direct assay. Source: FlyBase
Cellular component	integral to membrane Inferred from direct assay. Source: FlyBase
Molecular function	volume-sensitive chloride channel activity Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9V3J6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B37CD96DE2F15B15	FASTA	721	79,643
	10 20 30 40 50 60 MTITYTGEVA TCRGFGCFLK LLLRWRGSIY KLVWLDLLAF LTIYYAINMV YRFGLNPAQK 70 80 90 100 110 120 ETFEAIVQYC DSYRELIPLS FVLGFYVSIV MTRWWNQYTS IPWPDPIAVF VSSNVHGQDE 130 140 150 160 170 180 RGRMMRRTIM RYVCLCLTMV LANVSPRVKK RFPGLNNLVE AGLLNDNEKT IIETMNKAFP 190 200 210 220 230 240 RPSKHWLPIV WAASIITRAR KEGRIRDDFA VKTIIDELNK FRGQCGLLIS YDTISVPLVY 250 260 270 280 290 300 TQVVTLAVYS YFLTCCMGQQ WTDGKVVGNT TYLNKVDLYF PVFTTLQFFF YMGWLKVAES 310 320 330 340 350 360 LINPFGEDDD DFEVNWMVDR NLQVSYLIVD EMHHDHPELL KDQYWDEVFP NELPYTIAAE 370 380 390 400 410 420 RFRENHPEPS TAKIEVPKNA AMPSTMSSVR IDEMADDASG IHFSAGNGKM RLDSSPSLVS 430 440 450 460 470 480 VSGTLSRVNT VASALKRFLS RDDSRPGSAT PSQDQPYKFP ASASSASLSG AVVGSATSAG 490 500 510 520 530 540 KPAGSLRITQ QVIEEVDEQA TITSMRANDP RPNVMDIFAQ TSSGAGTSGP LQPPPAHSEP 550 560 570 580 590 600 VDIPSRPPSY NRAQSQYEPN LFPPGGVDAL LSTSAPAGGS PLLLSNAATA PSSPVGESSK 610 620 630 640 650 660 SLYDPQKGAS RETVESMDLR SSTDLLGDAA VQPEDEGDDF DKLKAEREKE KLMRQQKNLA 670 680 690 700 710 720 RTISTAPGME ATAVPMVPMV PVNVAVQQAQ LQPVASSADL LAGGDQFSNS TMKSEDAING S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL29094.1.
[4]	"dbest, a Drosophila Homolog of Human Bestrophin." Tavsanli B.C., Pappu K., Mardon G. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"The vitelliform macular dystrophy protein defines a new family of chloride channels." Sun H., Tsunenari T., Yau K.-W., Nathans J. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF218817 mRNA. Translation: AAF32327.1. AE014297 Genomic DNA. Translation: AAF54503.1. AY061546 mRNA. Translation: AAL29094.1. AY515709 mRNA. Translation: AAR99659.1.
RefSeq	NP_652603.1. NM_144346.2.
UniGene	Dm.3335.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-836535.
STRING	Q9V3J6.
Proteomic databases
PRIDE	Q9V3J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0082183; FBpp0081661; FBgn0040238.
GeneID	53431.
KEGG	dme:Dmel_CG6264.
NMPDR	fig|7227.3.peg.12040.
UCSC	CG6264-RA. d. melanogaster.
Organism-specific databases
CTD	7439.
FlyBase	FBgn0040238. Best1.
Phylogenomic databases
eggNOG	inNOG07075.
GeneTree	EMGT00050000005342.
InParanoid	Q9V3J6.
OMA	NQYTSIP.
PhylomeDB	Q9V3J6.
Gene expression databases
ArrayExpress	Q9V3J6.
Bgee	Q9V3J6.
Family and domain databases
InterPro	IPR000615. Bestrophin. IPR021134. Bestrophin/UPF0187. [Graphical view]
PANTHER	PTHR10736. Bestrophin. 1 hit.
Pfam	PF01062. Bestrophin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	841124.

Entry information

Entry name

Q9V3J6_DROME

Accession

Primary (citable) accession number: Q9V3J6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)