Reviewed, UniProtKB/Swiss-Prot Q9V3G7 (PSMD6_DROME)

Names and origin

Protein names

Recommended name:
    26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
    26S proteasome regulatory subunit S10
    Rpn7 protein

Gene names

Name:	Rpn7
ORF Names:	CG5378

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins By similarity.
Sequence similarities	Belongs to the proteasome subunit S10 family. Contains 1 PCI domain.

Ontologies

Keywords
Cellular component	Proteasome
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular process Inferred from mutant phenotype. Source: FlyBase proteolysis Inferred from direct assay. Source: FlyBase
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-KW proteasome regulatory particle Inferred from direct assay. Source: FlyBase
Molecular function	endopeptidase activity Inferred from direct assay. Source: FlyBase protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VKR4	1	EBI-181999,EBI-130625
Grasp65	Q9VW57	1	EBI-181999,EBI-100033

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	26S proteasome non-ATPase regulatory subunit 6		PRO_0000173841
Regions
	Domain	191 – 358	168	PCI

Sequences

	Sequence		Length	Mass (Da)
	Q9V3G7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CCC1DE0C7393B6FA	FASTA	389	45,381
	10 20 30 40 50 60 MPAENLEEQG LEKNPNLELA QTKFLLTLAE YKQDAALKAK LLEAIRTENM APWYEHICSE 70 80 90 100 110 120 LGWTVDKDLL ARMKENNRVE VEQLDAAIED AEKNLGEMEV REANLKKSEY LCRIGDKAAA 130 140 150 160 170 180 ETAFRKTYEK TVSLGHRLDI VFHLIRLGLF YLDHDLITRN IDKAKYLIEE GGDWDRRNRL 190 200 210 220 230 240 KVYQGVYSVA VRDFKAAATF FLDTVSTFTS YELMDYPTFV RYTVYVAMIA LPRNELRDKV 250 260 270 280 290 300 IKGSEIQEVL HGLPDVKQFL FSLYNCQYEN FYVHLAGVEK QLRLDYLIHP HYRYYVREMR 310 320 330 340 350 360 ILGYTQLLES YRSLTLQYMA ESFGVTVEYI DQELARFIAA GRLHAKVDRV GGIVETNRPD 370 380 NKNWQYQATI KQGDLLLNRI QKLSRVINI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The regulatory complex of the Drosophila 26S proteasomes." Hoelzl H., Kapelari B., Kellermann J., Nitsch M., Seemueller E., Voges D., Udvardy A., Mueller S.A., Engel A., Baumeister W. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Head.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF145308 mRNA. Translation: AAF08389.1. AE014297 Genomic DNA. Translation: AAF56000.1. AY052008 mRNA. Translation: AAK93432.1.
RefSeq	NP_651048.1.
UniGene	Dm.3424
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:23841N.
IntAct	Q9V3G7. 3 interactions.
Proteomic databases
PRIDE	Q9V3G7.
Genome annotation databases
Ensembl	FBgn0028688. Drosophila melanogaster. [Contig view]
GeneID	42641.
KEGG	dme:Dmel_CG5378.
NMPDR	fig|7227.3.peg.14071.
Organism-specific databases
FlyBase	FBgn0028688. Rpn7.
Phylogenomic databases
OMA	Q9V3G7. HDLITRN.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-012822-MON.
BRENDA	3.4.25.1. 48.
Gene expression databases
ArrayExpress	Q9V3G7.
GermOnline	CG5378. Drosophila melanogaster.
Family and domain databases
InterPro	IPR019585. 26S_proteasome_reg_su-Rpn7. IPR000717. PCI. [Graphical view]
Pfam	PF01399. PCI. 1 hit. PF10602. RPN7. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	829829.

Entry information

Entry name

PSMD6_DROME

Accession

Primary (citable) accession number: Q9V3G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project