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Protein

26S proteasome non-ATPase regulatory subunit 6

Gene

Rpn7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
26S proteasome regulatory subunit S10
Protein Rpn7
Gene namesi
Name:Rpn7
ORF Names:CG5378
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028688. Rpn7.

Subcellular locationi

GO - Cellular componenti

  • proteasome complex Source: FlyBase
  • proteasome regulatory particle Source: FlyBase
  • proteasome regulatory particle, lid subcomplex Source: FlyBase

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738411 – 38926S proteasome non-ATPase regulatory subunit 6Add BLAST389

Proteomic databases

PaxDbiQ9V3G7.
PRIDEiQ9V3G7.

Expressioni

Gene expression databases

BgeeiFBgn0028688.
GenevisibleiQ9V3G7. DM.

Interactioni

Protein-protein interaction databases

BioGridi67596. 34 interactors.
DIPiDIP-23841N.
IntActiQ9V3G7. 6 interactors.
MINTiMINT-845287.
STRINGi7227.FBpp0083687.

Structurei

3D structure databases

ProteinModelPortaliQ9V3G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 358PCIAdd BLAST168

Sequence similaritiesi

Belongs to the proteasome subunit S10 family.Curated

Phylogenomic databases

eggNOGiKOG0687. Eukaryota.
COG5187. LUCA.
InParanoidiQ9V3G7.
KOiK03037.
OMAiVDYIDQE.
OrthoDBiEOG091G03SE.
PhylomeDBiQ9V3G7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR019585. Rpn7/CSN1.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V3G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAENLEEQG LEKNPNLELA QTKFLLTLAE YKQDAALKAK LLEAIRTENM
60 70 80 90 100
APWYEHICSE LGWTVDKDLL ARMKENNRVE VEQLDAAIED AEKNLGEMEV
110 120 130 140 150
REANLKKSEY LCRIGDKAAA ETAFRKTYEK TVSLGHRLDI VFHLIRLGLF
160 170 180 190 200
YLDHDLITRN IDKAKYLIEE GGDWDRRNRL KVYQGVYSVA VRDFKAAATF
210 220 230 240 250
FLDTVSTFTS YELMDYPTFV RYTVYVAMIA LPRNELRDKV IKGSEIQEVL
260 270 280 290 300
HGLPDVKQFL FSLYNCQYEN FYVHLAGVEK QLRLDYLIHP HYRYYVREMR
310 320 330 340 350
ILGYTQLLES YRSLTLQYMA ESFGVTVEYI DQELARFIAA GRLHAKVDRV
360 370 380
GGIVETNRPD NKNWQYQATI KQGDLLLNRI QKLSRVINI
Length:389
Mass (Da):45,381
Last modified:May 1, 2000 - v1
Checksum:iCCC1DE0C7393B6FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145308 mRNA. Translation: AAF08389.1.
AE014297 Genomic DNA. Translation: AAF56000.1.
AY052008 mRNA. Translation: AAK93432.1.
RefSeqiNP_651048.1. NM_142791.3.
UniGeneiDm.3424.

Genome annotation databases

EnsemblMetazoaiFBtr0084294; FBpp0083687; FBgn0028688.
GeneIDi42641.
KEGGidme:Dmel_CG5378.
UCSCiCG5378-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPSMD6_DROME
AccessioniPrimary (citable) accession number: Q9V3G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families