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Protein

Peptidyl-prolyl cis-trans isomerase E

Gene

cyp33

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  • mRNA splicing, via spliceosome Source: FlyBase
  • protein folding Source: InterPro

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase

Enzyme and pathway databases

ReactomeiR-DME-6781823 Formation of TC-NER Pre-Incision Complex
R-DME-6782135 Dual incision in TC-NER
R-DME-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6798695 Neutrophil degranulation
R-DME-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase E (EC:5.2.1.8)
Short name:
PPIase E
Alternative name(s):
Cyclophilin 33
Cyclophilin E
Rotamase E
Gene namesi
Name:cyp33
ORF Names:CG4886
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0028382 cyp33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641591 – 300Peptidyl-prolyl cis-trans isomerase EAdd BLAST300

Proteomic databases

PaxDbiQ9V3G3
PRIDEiQ9V3G3

Expressioni

Gene expression databases

BgeeiFBgn0028382
GenevisibleiQ9V3G3 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
trxP206592EBI-128445,EBI-591327

Protein-protein interaction databases

BioGridi62673, 3 interactors
DIPiDIP-21959N
IntActiQ9V3G3, 3 interactors
STRINGi7227.FBpp0086101

Structurei

3D structure databases

ProteinModelPortaliQ9V3G3
SMRiQ9V3G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79
Domaini142 – 298PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0111 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
InParanoidiQ9V3G3
KOiK09564
OMAiFNLKHNS
OrthoDBiEOG091G0BGL
PhylomeDBiQ9V3G3

Family and domain databases

CDDicd12347 RRM_PPIE, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR016304 PPIE
IPR034168 PPIE_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF001475 PPI_cyclophilin_E, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V3G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDKRTIYV GGLADEVTER LLNNAFIPFG DIADIQMPAD YESQRHRGFA
60 70 80 90 100
FIEYEQSEDA AAAIDNMNDS ELCGRTIRVN LAKPVRVKED SFKPIWADDD
110 120 130 140 150
WLQKHAGATL QPEGEPEAEK VETPSTGPAV IEKAEKRNPQ VFFDIRIGGN
160 170 180 190 200
DAGRIVMLLR ADVVPKTAEN FRQLCTHEQG YGYKGCSFHR VIPEFMCQGG
210 220 230 240 250
DFTNNNGTGG KSIYGKKFND ENFNLKHNSF GTLSMANSGA NTNGSQFFIC
260 270 280 290 300
TTKTDWLDNK HVVFGHVISG AEVVRKMERC GSKSGTPSQK IVIYSCGELK
Length:300
Mass (Da):33,276
Last modified:May 1, 2000 - v1
Checksum:iCEAC7156EE8632D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182826 mRNA Translation: AAF01031.1
AE013599 Genomic DNA Translation: AAF57839.1
AY061421 mRNA Translation: AAL28969.1
RefSeqiNP_523773.1, NM_079049.4
UniGeneiDm.2854

Genome annotation databases

EnsemblMetazoaiFBtr0086945; FBpp0086101; FBgn0028382
GeneIDi36984
KEGGidme:Dmel_CG4886
UCSCiCG4886-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPPIE_DROME
AccessioniPrimary (citable) accession number: Q9V3G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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