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Protein

Peptidyl-prolyl cis-trans isomerase E

Gene

cyp33

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  • mRNA splicing, via spliceosome Source: FlyBase
  • phagocytosis Source: FlyBase
  • protein folding Source: InterPro

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase

Enzyme and pathway databases

ReactomeiR-DME-6781823. Formation of TC-NER Pre-Incision Complex.
R-DME-6782135. Dual incision in TC-NER.
R-DME-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-DME-6798695. Neutrophil degranulation.
R-DME-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase E (EC:5.2.1.8)
Short name:
PPIase E
Alternative name(s):
Cyclophilin 33
Cyclophilin E
Rotamase E
Gene namesi
Name:cyp33
ORF Names:CG4886
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0028382. cyp33.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641591 – 300Peptidyl-prolyl cis-trans isomerase EAdd BLAST300

Proteomic databases

PaxDbiQ9V3G3.
PRIDEiQ9V3G3.

Expressioni

Gene expression databases

BgeeiFBgn0028382.
GenevisibleiQ9V3G3. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
trxP206592EBI-128445,EBI-591327

Protein-protein interaction databases

BioGridi62673. 3 interactors.
DIPiDIP-21959N.
IntActiQ9V3G3. 3 interactors.
MINTiMINT-1643160.
STRINGi7227.FBpp0086101.

Structurei

3D structure databases

ProteinModelPortaliQ9V3G3.
SMRiQ9V3G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79
Domaini142 – 298PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0111. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
InParanoidiQ9V3G3.
KOiK09564.
OMAiIAKPMRI.
OrthoDBiEOG091G0BGL.
PhylomeDBiQ9V3G3.

Family and domain databases

CDDicd12347. RRM_PPIE. 1 hit.
Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR016304. PPIE.
IPR034168. PPIE_RRM.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
PIRSFiPIRSF001475. PPI_cyclophilin_E. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V3G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDKRTIYV GGLADEVTER LLNNAFIPFG DIADIQMPAD YESQRHRGFA
60 70 80 90 100
FIEYEQSEDA AAAIDNMNDS ELCGRTIRVN LAKPVRVKED SFKPIWADDD
110 120 130 140 150
WLQKHAGATL QPEGEPEAEK VETPSTGPAV IEKAEKRNPQ VFFDIRIGGN
160 170 180 190 200
DAGRIVMLLR ADVVPKTAEN FRQLCTHEQG YGYKGCSFHR VIPEFMCQGG
210 220 230 240 250
DFTNNNGTGG KSIYGKKFND ENFNLKHNSF GTLSMANSGA NTNGSQFFIC
260 270 280 290 300
TTKTDWLDNK HVVFGHVISG AEVVRKMERC GSKSGTPSQK IVIYSCGELK
Length:300
Mass (Da):33,276
Last modified:May 1, 2000 - v1
Checksum:iCEAC7156EE8632D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182826 mRNA. Translation: AAF01031.1.
AE013599 Genomic DNA. Translation: AAF57839.1.
AY061421 mRNA. Translation: AAL28969.1.
RefSeqiNP_523773.1. NM_079049.4.
UniGeneiDm.2854.

Genome annotation databases

EnsemblMetazoaiFBtr0086945; FBpp0086101; FBgn0028382.
GeneIDi36984.
KEGGidme:Dmel_CG4886.
UCSCiCG4886-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiPPIE_DROME
AccessioniPrimary (citable) accession number: Q9V3G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families