Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L8

Gene

RpL8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • compound eye development Source: FlyBase
  • cytoplasmic translation Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • regulation of cell size Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L8
Gene namesi
Name:RpL8
ORF Names:CG1263
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261602 RpL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001297541 – 25660S ribosomal protein L8Add BLAST256

Proteomic databases

PaxDbiQ9V3G1
PRIDEiQ9V3G1

Expressioni

Tissue specificityi

In larvae tissues examined: gut, brain imaginal disk, salivary glands, fat body, muscles, epidermis and trachaea.1 Publication

Developmental stagei

Expressed both maternally and zygotically in all stages.1 Publication

Gene expression databases

BgeeiFBgn0261602
GenevisibleiQ9V3G1 DM

Interactioni

Protein-protein interaction databases

BioGridi68919, 21 interactors
IntActiQ9V3G1, 6 interactors
STRINGi7227.FBpp0072801

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CA1-256[»]
ProteinModelPortaliQ9V3G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2309 Eukaryota
COG0090 LUCA
GeneTreeiENSGT00390000009907
InParanoidiQ9V3G1
KOiK02938
OMAiHGYIKGV
OrthoDBiEOG091G0K1G
PhylomeDBiQ9V3G1

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR022669 Ribosomal_L2_C
IPR022671 Ribosomal_L2_CS
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00467 RIBOSOMAL_L2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V3G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVIRAQRK GAGSVFKAHV KKRKGAAKLR SLDFAERSGY IRGVVKDIIH
60 70 80 90 100
DPGRGAPLAV VHFRDPYRYK IRKELFIAPE GMHTGQFVYC GRKATLQIGN
110 120 130 140 150
VMPLSQMPEG TIICNLEEKT GDRGRLARTS GNYATVIAHN QDTKKTRVKL
160 170 180 190 200
PSGAKKVVPS ANRAMVGIVA GGGRIDKPIL KAGRAYHKYK VKRNSWPKVR
210 220 230 240 250
GVAMNPVEHP HGGGNHQHIG KASTVKRGTS AGRKVGLIAA RRTGRIRGGK

GDSKDK
Length:256
Mass (Da):27,893
Last modified:May 1, 2000 - v1
Checksum:iD14B70E8D13148FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098520 Genomic DNA Translation: AAF06828.1
AE014296 Genomic DNA Translation: AAF47659.1
AE014296 Genomic DNA Translation: AAF47660.1
AY071342 mRNA Translation: AAL48964.1
BT014913 mRNA Translation: AAT47764.1
RefSeqiNP_524726.1, NM_079987.3
NP_728756.1, NM_167955.2
UniGeneiDm.6647

Genome annotation databases

EnsemblMetazoaiFBtr0072924; FBpp0072801; FBgn0261602
FBtr0072925; FBpp0072802; FBgn0261602
GeneIDi44251
KEGGidme:Dmel_CG1263

Similar proteinsi

Entry informationi

Entry nameiRL8_DROME
AccessioniPrimary (citable) accession number: Q9V3G1
Secondary accession number(s): A4V1C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health