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Protein

60S ribosomal protein L8

Gene

RpL8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • compound eye development Source: FlyBase
  • cytoplasmic translation Source: GO_Central
  • insulin receptor signaling pathway Source: FlyBase
  • mitotic spindle elongation Source: FlyBase
  • mitotic spindle organization Source: FlyBase
  • regulation of cell size Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L8
Gene namesi
Name:RpL8
ORF Names:CG1263
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261602. RpL8.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • cytosolic large ribosomal subunit Source: GO_Central
  • nuclear chromosome Source: FlyBase
  • nucleolus Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25625660S ribosomal protein L8PRO_0000129754Add
BLAST

Proteomic databases

PaxDbiQ9V3G1.
PRIDEiQ9V3G1.

Expressioni

Tissue specificityi

In larvae tissues examined: gut, brain imaginal disk, salivary glands, fat body, muscles, epidermis and trachaea.1 Publication

Developmental stagei

Expressed both maternally and zygotically in all stages.1 Publication

Gene expression databases

BgeeiFBgn0261602.
GenevisibleiQ9V3G1. DM.

Interactioni

Protein-protein interaction databases

BioGridi68919. 8 interactions.
MINTiMINT-290075.
STRINGi7227.FBpp0072801.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CA1-256[»]
ProteinModelPortaliQ9V3G1.
SMRiQ9V3G1. Positions 14-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.Curated

Phylogenomic databases

eggNOGiKOG2309. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000009907.
InParanoidiQ9V3G1.
KOiK02938.
OMAiHGYIKGV.
OrthoDBiEOG091G0K1G.
PhylomeDBiQ9V3G1.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V3G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVIRAQRK GAGSVFKAHV KKRKGAAKLR SLDFAERSGY IRGVVKDIIH
60 70 80 90 100
DPGRGAPLAV VHFRDPYRYK IRKELFIAPE GMHTGQFVYC GRKATLQIGN
110 120 130 140 150
VMPLSQMPEG TIICNLEEKT GDRGRLARTS GNYATVIAHN QDTKKTRVKL
160 170 180 190 200
PSGAKKVVPS ANRAMVGIVA GGGRIDKPIL KAGRAYHKYK VKRNSWPKVR
210 220 230 240 250
GVAMNPVEHP HGGGNHQHIG KASTVKRGTS AGRKVGLIAA RRTGRIRGGK

GDSKDK
Length:256
Mass (Da):27,893
Last modified:May 1, 2000 - v1
Checksum:iD14B70E8D13148FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098520 Genomic DNA. Translation: AAF06828.1.
AE014296 Genomic DNA. Translation: AAF47659.1.
AE014296 Genomic DNA. Translation: AAF47660.1.
AY071342 mRNA. Translation: AAL48964.1.
BT014913 mRNA. Translation: AAT47764.1.
RefSeqiNP_524726.1. NM_079987.3.
NP_728756.1. NM_167955.2.
UniGeneiDm.6647.

Genome annotation databases

EnsemblMetazoaiFBtr0072924; FBpp0072801; FBgn0261602.
FBtr0072925; FBpp0072802; FBgn0261602.
GeneIDi44251.
KEGGidme:Dmel_CG1263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098520 Genomic DNA. Translation: AAF06828.1.
AE014296 Genomic DNA. Translation: AAF47659.1.
AE014296 Genomic DNA. Translation: AAF47660.1.
AY071342 mRNA. Translation: AAL48964.1.
BT014913 mRNA. Translation: AAT47764.1.
RefSeqiNP_524726.1. NM_079987.3.
NP_728756.1. NM_167955.2.
UniGeneiDm.6647.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CA1-256[»]
ProteinModelPortaliQ9V3G1.
SMRiQ9V3G1. Positions 14-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68919. 8 interactions.
MINTiMINT-290075.
STRINGi7227.FBpp0072801.

Proteomic databases

PaxDbiQ9V3G1.
PRIDEiQ9V3G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072924; FBpp0072801; FBgn0261602.
FBtr0072925; FBpp0072802; FBgn0261602.
GeneIDi44251.
KEGGidme:Dmel_CG1263.

Organism-specific databases

CTDi6132.
FlyBaseiFBgn0261602. RpL8.

Phylogenomic databases

eggNOGiKOG2309. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000009907.
InParanoidiQ9V3G1.
KOiK02938.
OMAiHGYIKGV.
OrthoDBiEOG091G0K1G.
PhylomeDBiQ9V3G1.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL8. fly.
GenomeRNAii44251.
PROiQ9V3G1.

Gene expression databases

BgeeiFBgn0261602.
GenevisibleiQ9V3G1. DM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL8_DROME
AccessioniPrimary (citable) accession number: Q9V3G1
Secondary accession number(s): A4V1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.