Q9V3D2 (HEM6_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Coproporphyrinogen-III oxidase Short name=COX Short name=Coprogen oxidase Short name=Coproporphyrinogenase EC=1.3.3.3 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 390 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. |
| Catalytic activity | Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the aerobic coproporphyrinogen-III oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Heme biosynthesis Porphyrin biosynthesis |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC protein homodimerization activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| dl | P15330-2 | 1 | EBI-153438,EBI-198400 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 390 | 390 | Coproporphyrinogen-III oxidase | PRO_0000109875 | |||||
Regions | |||||||||
| Region | 131 – 140 | 10 | Important for dimerization By similarity | ||||||
| Region | 197 – 199 | 3 | Substrate binding By similarity | ||||||
| Region | 329 – 365 | 37 | Important for dimerization By similarity | ||||||
| Region | 348 – 353 | 6 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 195 | 1 | Proton donor By similarity | ||||||
| Binding site | 181 | 1 | Substrate By similarity | ||||||
| Site | 264 | 1 | Important for dimerization By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014134 Genomic DNA. Translation: AAF52469.1. AF160897 mRNA. Translation: AAD46837.1. |
| RefSeq | NP_524777.1. NM_080038.2. |
| UniGene | Dm.1822. |
3D structure databases | |
| ProteinModelPortal | Q9V3D2. |
| SMR | Q9V3D2. Positions 65-390. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-23030N. |
| IntAct | Q9V3D2. 1 interaction. |
| MINT | MINT-1024659. |
| STRING | Q9V3D2. |
Proteomic databases | |
| PRIDE | Q9V3D2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0079352; FBpp0078980; FBgn0021944. |
| GeneID | 44701. |
| KEGG | dme:Dmel_CG3433. |
| NMPDR | fig|7227.3.peg.1171. |
Organism-specific databases | |
| CTD | 44701. |
| FlyBase | FBgn0021944. Coprox. |
Phylogenomic databases | |
| eggNOG | inNOG04066. |
| GeneTree | EMGT00050000017297. |
| InParanoid | Q9V3D2. |
| OMA | VFKPWCD. |
| OrthoDB | EOG4BRV25. |
| PhylomeDB | Q9V3D2. |
Gene expression databases | |
| ArrayExpress | Q9V3D2. |
| Bgee | Q9V3D2. |
| GermOnline | CG3433. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR001260. Coprogen_oxidase_aer. IPR018375. Coprogen_oxidase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit. |
| KO | K00228. |
| PANTHER | PTHR10755. Coprogen_oxidas. 1 hit. |
| Pfam | PF01218. Coprogen_oxidas. 1 hit. [Graphical view] |
| PIRSF | PIRSF000166. Coproporphyri_ox. 1 hit. |
| PRINTS | PR00073. COPRGNOXDASE. |
| SUPFAM | SSF102886. Coprogen_oxidas. 1 hit. |
| PROSITE | PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 837551. |
Entry information
| Entry name | HEM6_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9V3D2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with