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Protein

Peptidoglycan-recognition protein SC1a/b

Gene

PGRP-SC1a

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi160ZincBy similarity1
Metal bindingi168ZincBy similarity1

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  • peptidoglycan binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • immune response Source: FlyBase
  • innate immune response Source: UniProtKB
  • negative regulation of innate immune response Source: FlyBase
  • peptidoglycan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC1a/b (EC:3.5.1.28)
Gene namesi
ORF Names:CG14746
AND
ORF Names:CG8577
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0043576. PGRP-SC1a.
FBgn0033327. PGRP-SC1b.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168C → A: Abolishes enzyme activity but retains PGN-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002391022 – 185Peptidoglycan-recognition protein SC1a/bAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9V3B7.
PRIDEiQ9V3B7.

Expressioni

Tissue specificityi

Constitutively expressed at high level in gut, in addition to the induced expression in fat body.1 Publication

Inductioni

Up-regulated by PGN from B.subtilis.1 Publication

Gene expression databases

BgeeiFBgn0033327.
ExpressionAtlasiQ9V3B7. baseline.
GenevisibleiQ9V3B7. DM.

Interactioni

Protein-protein interaction databases

BioGridi61708. 1 interactor.
61710. 1 interactor.
IntActiQ9V3B7. 1 interactor.
MINTiMINT-1610118.
STRINGi7227.FBpp0087787.

Structurei

3D structure databases

ProteinModelPortaliQ9V3B7.
SMRiQ9V3B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
InParanoidiQ9V3B7.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ9V3B7.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V3B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKVALLLA VLVCSQYMAQ GVYVVSKAEW GGRGAKWTVG LGNYLSYAII
60 70 80 90 100
HHTAGSYCET RAQCNAVLQS VQNYHMDSLG WPDIGYNFLI GGDGNVYEGR
110 120 130 140 150
GWNNMGAHAA EWNPYSIGIS FLGNYNWDTL EPNMISAAQQ LLNDAVNRGQ
160 170 180
LSSGYILYGH RQVSATECPG THIWNEIRGW SHWSG
Length:185
Mass (Da):20,395
Last modified:May 1, 2000 - v1
Checksum:iF23F8D80A33541AC
GO

Sequence cautioni

The sequence AAL28193 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178R → P in AAL28193 (PubMed:12537569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6A → T in PGRP-SC1a; strain: KY038 and in PGRP-SC1b; strain: KY024 and KY038. 1
Natural varianti13V → I in PGRP-SC1b; strain: KY024. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207542 mRNA. Translation: AAG23736.1.
AJ556588 Genomic DNA. Translation: CAD89153.1.
AJ556589 Genomic DNA. Translation: CAD89154.1.
AJ556590 Genomic DNA. Translation: CAD89155.1.
AJ556591 Genomic DNA. Translation: CAD89156.1.
AJ556592 Genomic DNA. Translation: CAD89157.1.
AJ556593 Genomic DNA. Translation: CAD89158.1.
AJ556594 Genomic DNA. Translation: CAD89159.1.
AJ556595 Genomic DNA. Translation: CAD89160.1.
AJ556596 Genomic DNA. Translation: CAD89161.1.
AJ556597 Genomic DNA. Translation: CAD89162.1.
AJ556598 Genomic DNA. Translation: CAD89163.1.
AJ556599 Genomic DNA. Translation: CAD89164.1.
AJ556600 Genomic DNA. Translation: CAD89165.1.
AJ556601 Genomic DNA. Translation: CAD89166.1.
AJ556602 Genomic DNA. Translation: CAD89167.1.
AJ556603 Genomic DNA. Translation: CAD89168.1.
AJ556604 Genomic DNA. Translation: CAD89169.1.
AJ556605 Genomic DNA. Translation: CAD89170.1.
AJ556606 Genomic DNA. Translation: CAD89171.1.
AJ556607 Genomic DNA. Translation: CAD89172.1.
AJ556608 Genomic DNA. Translation: CAD89173.1.
AJ556609 Genomic DNA. Translation: CAD89174.1.
AE013599 Genomic DNA. Translation: AAF59052.1.
AE013599 Genomic DNA. Translation: AAF59054.1.
AY060645 mRNA. Translation: AAL28193.2. Different initiation.
BT044352 mRNA. Translation: ACH92417.2.
RefSeqiNP_001286209.1. NM_001299280.1.
NP_610407.1. NM_136563.2.
NP_610409.1. NM_136565.2.
UniGeneiDm.3372.

Genome annotation databases

EnsemblMetazoaiFBtr0088707; FBpp0087786; FBgn0043576.
FBtr0088708; FBpp0087787; FBgn0033327.
FBtr0339336; FBpp0308436; FBgn0033327.
GeneIDi35859.
35861.
KEGGidme:Dmel_CG14746.
dme:Dmel_CG8577.
UCSCiCG14746-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207542 mRNA. Translation: AAG23736.1.
AJ556588 Genomic DNA. Translation: CAD89153.1.
AJ556589 Genomic DNA. Translation: CAD89154.1.
AJ556590 Genomic DNA. Translation: CAD89155.1.
AJ556591 Genomic DNA. Translation: CAD89156.1.
AJ556592 Genomic DNA. Translation: CAD89157.1.
AJ556593 Genomic DNA. Translation: CAD89158.1.
AJ556594 Genomic DNA. Translation: CAD89159.1.
AJ556595 Genomic DNA. Translation: CAD89160.1.
AJ556596 Genomic DNA. Translation: CAD89161.1.
AJ556597 Genomic DNA. Translation: CAD89162.1.
AJ556598 Genomic DNA. Translation: CAD89163.1.
AJ556599 Genomic DNA. Translation: CAD89164.1.
AJ556600 Genomic DNA. Translation: CAD89165.1.
AJ556601 Genomic DNA. Translation: CAD89166.1.
AJ556602 Genomic DNA. Translation: CAD89167.1.
AJ556603 Genomic DNA. Translation: CAD89168.1.
AJ556604 Genomic DNA. Translation: CAD89169.1.
AJ556605 Genomic DNA. Translation: CAD89170.1.
AJ556606 Genomic DNA. Translation: CAD89171.1.
AJ556607 Genomic DNA. Translation: CAD89172.1.
AJ556608 Genomic DNA. Translation: CAD89173.1.
AJ556609 Genomic DNA. Translation: CAD89174.1.
AE013599 Genomic DNA. Translation: AAF59052.1.
AE013599 Genomic DNA. Translation: AAF59054.1.
AY060645 mRNA. Translation: AAL28193.2. Different initiation.
BT044352 mRNA. Translation: ACH92417.2.
RefSeqiNP_001286209.1. NM_001299280.1.
NP_610407.1. NM_136563.2.
NP_610409.1. NM_136565.2.
UniGeneiDm.3372.

3D structure databases

ProteinModelPortaliQ9V3B7.
SMRiQ9V3B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61708. 1 interactor.
61710. 1 interactor.
IntActiQ9V3B7. 1 interactor.
MINTiMINT-1610118.
STRINGi7227.FBpp0087787.

Proteomic databases

PaxDbiQ9V3B7.
PRIDEiQ9V3B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088707; FBpp0087786; FBgn0043576.
FBtr0088708; FBpp0087787; FBgn0033327.
FBtr0339336; FBpp0308436; FBgn0033327.
GeneIDi35859.
35861.
KEGGidme:Dmel_CG14746.
dme:Dmel_CG8577.
UCSCiCG14746-RA. d. melanogaster.

Organism-specific databases

CTDi35859.
35861.
FlyBaseiFBgn0043576. PGRP-SC1a.
FBgn0033327. PGRP-SC1b.

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
InParanoidiQ9V3B7.
KOiK01446.
OMAiLWNPMSI.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ9V3B7.

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Miscellaneous databases

PROiQ9V3B7.

Gene expression databases

BgeeiFBgn0033327.
ExpressionAtlasiQ9V3B7. baseline.
GenevisibleiQ9V3B7. DM.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGSC1_DROME
AccessioniPrimary (citable) accession number: Q9V3B7
Secondary accession number(s): B5RJ78
, Q70PU9, Q70PV0, Q95SQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.