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Q9V3B7

- PGSC1_DROME

UniProt

Q9V3B7 - PGSC1_DROME

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Protein

Peptidoglycan-recognition protein SC1a/b

Gene
PGRP-SC1a, CG14746
PGRP-SC1b, CG8577
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.1 Publication

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Zinc By similarity
Metal bindingi86 – 861Zinc By similarity
Metal bindingi160 – 1601Zinc By similarity
Metal bindingi168 – 1681Zinc By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  2. peptidoglycan binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. immune response Source: FlyBase
  2. innate immune response Source: UniProtKB
  3. negative regulation of innate immune response Source: FlyBase
  4. peptidoglycan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC1a/b (EC:3.5.1.28)
Gene namesi
Name:PGRP-SC1a
ORF Names:CG14746
AND
Name:PGRP-SC1b
ORF Names:CG8577
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R
FlyBaseiFBgn0043576. PGRP-SC1a.
FBgn0033327. PGRP-SC1b.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi168 – 1681C → A: Abolishes enzyme activity but retains PGN-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 185164Peptidoglycan-recognition protein SC1a/bPRO_0000023910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 64 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9V3B7.
PRIDEiQ9V3B7.

Expressioni

Tissue specificityi

Constitutively expressed at high level in gut, in addition to the induced expression in fat body.1 Publication

Inductioni

Up-regulated by PGN from B.subtilis.1 Publication

Gene expression databases

BgeeiQ9V3B7.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CG9184Q9W0H11EBI-109541,EBI-143367

Protein-protein interaction databases

BioGridi61708. 1 interaction.
61710. 1 interaction.
IntActiQ9V3B7. 1 interaction.
MINTiMINT-1610118.
STRINGi7227.FBpp0087786.

Structurei

3D structure databases

ProteinModelPortaliQ9V3B7.
SMRiQ9V3B7. Positions 24-183.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5479.
GeneTreeiENSGT00390000016833.
InParanoidiQ9V3B7.
KOiK01446.
OMAiTLEPNMI.
OrthoDBiEOG757CZ5.
PhylomeDBiQ9V3B7.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V3B7-1 [UniParc]FASTAAdd to Basket

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MVSKVALLLA VLVCSQYMAQ GVYVVSKAEW GGRGAKWTVG LGNYLSYAII    50
HHTAGSYCET RAQCNAVLQS VQNYHMDSLG WPDIGYNFLI GGDGNVYEGR 100
GWNNMGAHAA EWNPYSIGIS FLGNYNWDTL EPNMISAAQQ LLNDAVNRGQ 150
LSSGYILYGH RQVSATECPG THIWNEIRGW SHWSG 185
Length:185
Mass (Da):20,395
Last modified:May 1, 2000 - v1
Checksum:iF23F8D80A33541AC
GO

Sequence cautioni

The sequence AAL28193.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → T in PGRP-SC1a; strain: KY038 and in PGRP-SC1b; strain: KY024 and KY038.
Natural varianti13 – 131V → I in PGRP-SC1b; strain: KY024.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781R → P in AAL28193. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207542 mRNA. Translation: AAG23736.1.
AJ556588 Genomic DNA. Translation: CAD89153.1.
AJ556589 Genomic DNA. Translation: CAD89154.1.
AJ556590 Genomic DNA. Translation: CAD89155.1.
AJ556591 Genomic DNA. Translation: CAD89156.1.
AJ556592 Genomic DNA. Translation: CAD89157.1.
AJ556593 Genomic DNA. Translation: CAD89158.1.
AJ556594 Genomic DNA. Translation: CAD89159.1.
AJ556595 Genomic DNA. Translation: CAD89160.1.
AJ556596 Genomic DNA. Translation: CAD89161.1.
AJ556597 Genomic DNA. Translation: CAD89162.1.
AJ556598 Genomic DNA. Translation: CAD89163.1.
AJ556599 Genomic DNA. Translation: CAD89164.1.
AJ556600 Genomic DNA. Translation: CAD89165.1.
AJ556601 Genomic DNA. Translation: CAD89166.1.
AJ556602 Genomic DNA. Translation: CAD89167.1.
AJ556603 Genomic DNA. Translation: CAD89168.1.
AJ556604 Genomic DNA. Translation: CAD89169.1.
AJ556605 Genomic DNA. Translation: CAD89170.1.
AJ556606 Genomic DNA. Translation: CAD89171.1.
AJ556607 Genomic DNA. Translation: CAD89172.1.
AJ556608 Genomic DNA. Translation: CAD89173.1.
AJ556609 Genomic DNA. Translation: CAD89174.1.
AE013599 Genomic DNA. Translation: AAF59052.1.
AE013599 Genomic DNA. Translation: AAF59054.1.
AY060645 mRNA. Translation: AAL28193.2. Different initiation.
BT044352 mRNA. Translation: ACH92417.2.
RefSeqiNP_610407.1. NM_136563.1.
NP_610409.1. NM_136565.1.
UniGeneiDm.3372.
Dm.38443.

Genome annotation databases

EnsemblMetazoaiFBtr0088707; FBpp0087786; FBgn0043576.
FBtr0088708; FBpp0087787; FBgn0033327.
GeneIDi35859.
35861.
KEGGidme:Dmel_CG14746.
dme:Dmel_CG8577.
UCSCiCG14746-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207542 mRNA. Translation: AAG23736.1 .
AJ556588 Genomic DNA. Translation: CAD89153.1 .
AJ556589 Genomic DNA. Translation: CAD89154.1 .
AJ556590 Genomic DNA. Translation: CAD89155.1 .
AJ556591 Genomic DNA. Translation: CAD89156.1 .
AJ556592 Genomic DNA. Translation: CAD89157.1 .
AJ556593 Genomic DNA. Translation: CAD89158.1 .
AJ556594 Genomic DNA. Translation: CAD89159.1 .
AJ556595 Genomic DNA. Translation: CAD89160.1 .
AJ556596 Genomic DNA. Translation: CAD89161.1 .
AJ556597 Genomic DNA. Translation: CAD89162.1 .
AJ556598 Genomic DNA. Translation: CAD89163.1 .
AJ556599 Genomic DNA. Translation: CAD89164.1 .
AJ556600 Genomic DNA. Translation: CAD89165.1 .
AJ556601 Genomic DNA. Translation: CAD89166.1 .
AJ556602 Genomic DNA. Translation: CAD89167.1 .
AJ556603 Genomic DNA. Translation: CAD89168.1 .
AJ556604 Genomic DNA. Translation: CAD89169.1 .
AJ556605 Genomic DNA. Translation: CAD89170.1 .
AJ556606 Genomic DNA. Translation: CAD89171.1 .
AJ556607 Genomic DNA. Translation: CAD89172.1 .
AJ556608 Genomic DNA. Translation: CAD89173.1 .
AJ556609 Genomic DNA. Translation: CAD89174.1 .
AE013599 Genomic DNA. Translation: AAF59052.1 .
AE013599 Genomic DNA. Translation: AAF59054.1 .
AY060645 mRNA. Translation: AAL28193.2 . Different initiation.
BT044352 mRNA. Translation: ACH92417.2 .
RefSeqi NP_610407.1. NM_136563.1.
NP_610409.1. NM_136565.1.
UniGenei Dm.3372.
Dm.38443.

3D structure databases

ProteinModelPortali Q9V3B7.
SMRi Q9V3B7. Positions 24-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61708. 1 interaction.
61710. 1 interaction.
IntActi Q9V3B7. 1 interaction.
MINTi MINT-1610118.
STRINGi 7227.FBpp0087786.

Proteomic databases

PaxDbi Q9V3B7.
PRIDEi Q9V3B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088707 ; FBpp0087786 ; FBgn0043576 .
FBtr0088708 ; FBpp0087787 ; FBgn0033327 .
GeneIDi 35859.
35861.
KEGGi dme:Dmel_CG14746.
dme:Dmel_CG8577.
UCSCi CG14746-RA. d. melanogaster.

Organism-specific databases

CTDi 35859.
35861.
FlyBasei FBgn0043576. PGRP-SC1a.
FBgn0033327. PGRP-SC1b.

Phylogenomic databases

eggNOGi COG5479.
GeneTreei ENSGT00390000016833.
InParanoidi Q9V3B7.
KOi K01446.
OMAi TLEPNMI.
OrthoDBi EOG757CZ5.
PhylomeDBi Q9V3B7.

Miscellaneous databases

NextBioi 795548.

Gene expression databases

Bgeei Q9V3B7.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037945. PGRPs. 1 hit.
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster."
    Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.
    Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (PGRP-SC1B), PGN-BINDING, TISSUE SPECIFICITY, INDUCTION.
  2. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (PGRP-SC1A AND PGRP-SC1B).
    Strain: DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti, Texas and ZW141.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (PGRP-SC1A AND PGRP-SC1B).
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (PGRP-SC1B).
    Strain: Berkeley.
    Tissue: Head.
  6. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (PGRP-SC1B).
    Strain: Berkeley.
    Tissue: Head.
  7. "A scavenger function for a Drosophila peptidoglycan recognition protein."
    Mellroth P., Karlsson J., Steiner H.
    J. Biol. Chem. 278:7059-7064(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY (PGRP-SC1B), PGN-BINDING, MUTAGENESIS OF CYS-168.

Entry informationi

Entry nameiPGSC1_DROME
AccessioniPrimary (citable) accession number: Q9V3B7
Secondary accession number(s): B5RJ78
, Q70PU9, Q70PV0, Q95SQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi