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Protein

Probable lysine-specific demethylase 4A

Gene

Kdm4A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1392-oxoglutarateBy similarity1
Metal bindingi195Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi197Iron; catalyticPROSITE-ProRule annotation1
Binding sitei2052-oxoglutarateBy similarity1
Binding sitei2132-oxoglutarateBy similarity1
Metal bindingi241ZincBy similarity1
Metal bindingi247ZincBy similarity1
Binding sitei2482-oxoglutarateBy similarity1
Metal bindingi283Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi313ZincBy similarity1
Metal bindingi315ZincBy similarity1

GO - Molecular functioni

  • histone demethylase activity (H3-K36 specific) Source: FlyBase
  • histone demethylase activity (H3-K9 specific) Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • histone demethylation Source: UniProtKB
  • histone H3-K36 demethylation Source: FlyBase
  • histone H3-K9 demethylation Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of gene expression Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.14.11.27. 1994.
1.14.11.B1. 1994.
ReactomeiR-DME-3214842. HDMs demethylate histones.
R-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysine-specific demethylase 4A (EC:1.14.11.-)
Alternative name(s):
Probable JmjC domain-containing histone demethylation protein 3A
Gene namesi
Name:Kdm4A
ORF Names:CG15835
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033233. Kdm4A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343791 – 495Probable lysine-specific demethylase 4AAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V333.
PRIDEiQ9V333.

PTM databases

iPTMnetiQ9V333.

Expressioni

Gene expression databases

BgeeiFBgn0033233.
ExpressionAtlasiQ9V333. differential.
GenevisibleiQ9V333. DM.

Interactioni

Protein-protein interaction databases

BioGridi61608. 7 interactors.
IntActiQ9V333. 1 interactor.
MINTiMINT-800097.
STRINGi7227.FBpp0087961.

Structurei

3D structure databases

ProteinModelPortaliQ9V333.
SMRiQ9V333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 60JmjNPROSITE-ProRule annotationAdd BLAST43
Domaini149 – 315JmjCPROSITE-ProRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the JHDM3 histone demethylase family.Curated

Phylogenomic databases

eggNOGiKOG0958. Eukaryota.
ENOG410XP0T. LUCA.
GeneTreeiENSGT00530000063342.
InParanoidiQ9V333.
KOiK06709.
OMAiKNTKRMR.
OrthoDBiEOG091G01FR.
PhylomeDBiQ9V333.

Family and domain databases

InterProiView protein in InterPro
IPR003347. JmjC_dom.
IPR003349. JmjN.
PfamiView protein in Pfam
PF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
SMARTiView protein in SMART
SM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
PROSITEiView protein in PROSITE
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRSSFADE EQNKVPRIMT FRPSYEEFQN FSAYIEYIES RGAHLAGLAK
60 70 80 90 100
IQPPAEWVPR KSGYDIDNIN MTIPAPICQV VTGAHGVYQQ INIQQRRQMT
110 120 130 140 150
LRQFMEKANS ELHQTPRHFD YDDLERKYWK NITYISPLYA ADVKGSLSDE
160 170 180 190 200
DLDVWNIGRL DTILNLVNTD YNIIIDGVNT AYLYFGMWKS SFAWHTEDMD
210 220 230 240 250
LYSINYLHFG APKTWYAIPP AYGRRLEKLA NETFSENYQE CNAYLRHKMT
260 270 280 290 300
MISPKVLRQH NIPYNKITQE AGEIMITFPF GYHAGFNHGF NGAESTNFAS
310 320 330 340 350
KRWIEYGKRA SICRCRSDMV KISMETFVRR FQPERYDNWL KGQDMGCHPE
360 370 380 390 400
EPGKICAAAP PTLNEYEKQE NLRAAKSEEE SPQKRGCSLA GNGCERNAES
410 420 430 440 450
AEDVDDKASV SSYSSCRQLQ PVVKLRKLPT IASVPEPSSA PKRYDFNTEA
460 470 480 490
VVRVKRLWNE LPCPDRGANL LTNGVVKNTK RMRFQTKVLT LDDED
Length:495
Mass (Da):56,990
Last modified:May 1, 2000 - v1
Checksum:i75EF4AC188C834A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59172.1.
AY058636 mRNA. Translation: AAL13865.1.
RefSeqiNP_610331.1. NM_136487.4.
UniGeneiDm.4139.

Genome annotation databases

EnsemblMetazoaiFBtr0088886; FBpp0087961; FBgn0033233.
GeneIDi35744.
KEGGidme:Dmel_CG15835.
UCSCiCG15835-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiKDM4A_DROME
AccessioniPrimary (citable) accession number: Q9V333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families