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Protein

Probable lysine-specific demethylase 4A

Gene

Kdm4A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139Alpha-ketoglutarateBy similarity1
Metal bindingi195Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi197Iron; catalyticPROSITE-ProRule annotation1
Binding sitei205Alpha-ketoglutarateBy similarity1
Binding sitei213Alpha-ketoglutarateBy similarity1
Metal bindingi241ZincBy similarity1
Metal bindingi247ZincBy similarity1
Metal bindingi283Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi313ZincBy similarity1
Metal bindingi315ZincBy similarity1

GO - Molecular functioni

  • histone demethylase activity (H3-K36 specific) Source: UniProtKB
  • histone demethylase activity (H3-K9 specific) Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • histone demethylation Source: UniProtKB
  • histone H3-K36 demethylation Source: FlyBase
  • histone H3-K9 demethylation Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of gene expression Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.14.11.27. 1994.
1.14.11.B1. 1994.
ReactomeiR-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysine-specific demethylase 4A (EC:1.14.11.-)
Alternative name(s):
Probable JmjC domain-containing histone demethylation protein 3A
Gene namesi
Name:Kdm4A
ORF Names:CG15835
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033233. Kdm4A.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343791 – 495Probable lysine-specific demethylase 4AAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9V333.
PRIDEiQ9V333.

PTM databases

iPTMnetiQ9V333.

Expressioni

Gene expression databases

BgeeiFBgn0033233.
ExpressionAtlasiQ9V333. baseline.
GenevisibleiQ9V333. DM.

Interactioni

Protein-protein interaction databases

BioGridi61608. 3 interactors.
IntActiQ9V333. 1 interactor.
MINTiMINT-800097.
STRINGi7227.FBpp0087961.

Structurei

3D structure databases

ProteinModelPortaliQ9V333.
SMRiQ9V333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 60JmjNPROSITE-ProRule annotationAdd BLAST43
Domaini149 – 315JmjCPROSITE-ProRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the JHDM3 histone demethylase family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation
Contains 1 JmjN domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0958. Eukaryota.
ENOG410XP0T. LUCA.
GeneTreeiENSGT00530000063342.
InParanoidiQ9V333.
KOiK06709.
OMAiKNTKRMR.
OrthoDBiEOG091G01FR.
PhylomeDBiQ9V333.

Family and domain databases

InterProiIPR003347. JmjC_dom.
IPR003349. JmjN.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRSSFADE EQNKVPRIMT FRPSYEEFQN FSAYIEYIES RGAHLAGLAK
60 70 80 90 100
IQPPAEWVPR KSGYDIDNIN MTIPAPICQV VTGAHGVYQQ INIQQRRQMT
110 120 130 140 150
LRQFMEKANS ELHQTPRHFD YDDLERKYWK NITYISPLYA ADVKGSLSDE
160 170 180 190 200
DLDVWNIGRL DTILNLVNTD YNIIIDGVNT AYLYFGMWKS SFAWHTEDMD
210 220 230 240 250
LYSINYLHFG APKTWYAIPP AYGRRLEKLA NETFSENYQE CNAYLRHKMT
260 270 280 290 300
MISPKVLRQH NIPYNKITQE AGEIMITFPF GYHAGFNHGF NGAESTNFAS
310 320 330 340 350
KRWIEYGKRA SICRCRSDMV KISMETFVRR FQPERYDNWL KGQDMGCHPE
360 370 380 390 400
EPGKICAAAP PTLNEYEKQE NLRAAKSEEE SPQKRGCSLA GNGCERNAES
410 420 430 440 450
AEDVDDKASV SSYSSCRQLQ PVVKLRKLPT IASVPEPSSA PKRYDFNTEA
460 470 480 490
VVRVKRLWNE LPCPDRGANL LTNGVVKNTK RMRFQTKVLT LDDED
Length:495
Mass (Da):56,990
Last modified:May 1, 2000 - v1
Checksum:i75EF4AC188C834A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59172.1.
AY058636 mRNA. Translation: AAL13865.1.
RefSeqiNP_610331.1. NM_136487.4.
UniGeneiDm.4139.

Genome annotation databases

EnsemblMetazoaiFBtr0088886; FBpp0087961; FBgn0033233.
GeneIDi35744.
KEGGidme:Dmel_CG15835.
UCSCiCG15835-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59172.1.
AY058636 mRNA. Translation: AAL13865.1.
RefSeqiNP_610331.1. NM_136487.4.
UniGeneiDm.4139.

3D structure databases

ProteinModelPortaliQ9V333.
SMRiQ9V333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61608. 3 interactors.
IntActiQ9V333. 1 interactor.
MINTiMINT-800097.
STRINGi7227.FBpp0087961.

PTM databases

iPTMnetiQ9V333.

Proteomic databases

PaxDbiQ9V333.
PRIDEiQ9V333.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088886; FBpp0087961; FBgn0033233.
GeneIDi35744.
KEGGidme:Dmel_CG15835.
UCSCiCG15835-RA. d. melanogaster.

Organism-specific databases

CTDi9682.
FlyBaseiFBgn0033233. Kdm4A.

Phylogenomic databases

eggNOGiKOG0958. Eukaryota.
ENOG410XP0T. LUCA.
GeneTreeiENSGT00530000063342.
InParanoidiQ9V333.
KOiK06709.
OMAiKNTKRMR.
OrthoDBiEOG091G01FR.
PhylomeDBiQ9V333.

Enzyme and pathway databases

BRENDAi1.14.11.27. 1994.
1.14.11.B1. 1994.
ReactomeiR-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Miscellaneous databases

ChiTaRSiKdm4A. fly.
GenomeRNAii35744.
PROiQ9V333.

Gene expression databases

BgeeiFBgn0033233.
ExpressionAtlasiQ9V333. baseline.
GenevisibleiQ9V333. DM.

Family and domain databases

InterProiIPR003347. JmjC_dom.
IPR003349. JmjN.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDM4A_DROME
AccessioniPrimary (citable) accession number: Q9V333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.