Q9V2M6 (APGM_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	PYRAB00490
ORF Names:	PAB2318

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_0000138142

Sequences

	Sequence		Length	Mass (Da)
	Q9V2M6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 91C8A89637608826	FASTA	410	45,202
	10 20 30 40 50 60 MQRKGILIIL DGLGDRPIKE LGGLTPLEYA NTPNMDKLAK IGILGQQDPI KPGQPAGSDT 70 80 90 100 110 120 AHLSIFGYDP YKTYRGRGFF EALGVGLDLD EDDLAFRVNF ATLKDGIVVD RRAGRISTEE 130 140 150 160 170 180 AHELAKAIQE EVDVGVDFIF KGATGHRAVL VLKGMADGYR VGDNDPHVEG KPPHKFSWED 190 200 210 220 230 240 EESKKVAEIL EEFVKKAHEV LERHPINEKR RREGKPVANY LLIRGAGTYP NIPMKFTEQW 250 260 270 280 290 300 KVKAAAVIAV ALVKGVARAI GFDVYTPEGA TGEYNTNEMA KAKKVVELLK DYDFVFLHFK 310 320 330 340 350 360 PTDAAGHDNK PKLKAELIER ADKMIGYIID NIDLESTVIA ITGDHSTPCE VKNHSGDPVP 370 380 390 400 410 LLIAGGGVRT DHTERFGERE AMKGGLGRIR GHDIVPIMMD LMNRSEKFGA

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248283 Genomic DNA. Translation: CAB48972.1.
PIR	E75190.
RefSeq	NP_125741.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V2M6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003790; EBPYRP00000003721; EBPYRG00000003790.
GeneID	1494932.
GenomeReviews	Gene locus PYRAB00490 in contig AL096836_GR.
KEGG	pab:PAB2318.
NMPDR	fig|272844.1.peg.56.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023120.
HOGENOM	HBG463247.
OMA	DIAFRCN.
ProtClustDB	PRK04024.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2318-MONOMER.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_PYRAB

Accession

Primary (citable) accession number: Q9V2M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program