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Q9V2I6 (ALF1_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fba
Ordered Locus Names:PYRAB00890
ORF Names:PAB0049
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulation

Activated by citrate By similarity.

Subunit structure

Homooctamer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the DeoC/FbaB aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Fructose-bisphosphate aldolase class 1
PRO_0000138948

Sites

Active site1911Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9V2I6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6BFFCA8A4441D5A5

FASTA28131,222
        10         20         30         40         50         60 
MEALQNIGIK RRLRRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV IIRKVVRAGV 

        70         80         90        100        110        120 
DGVMMLPGMA RIAGDDVKPE VGLMIKITSK TNLRPKAEQL MQSQLAFVED AIKLGADAIA 

       130        140        150        160        170        180 
ATVYWGSPQE DAMMRQFAEI VSYAHDLGFP VVQFAYPRGP YIDEKYGRKE DYRVVMYGAR 

       190        200        210        220        230        240 
AAAEMGADMI KTYWTGSRET FAKVVDAAAG VPVLLSGGAK AENPLDFLKV VYEVIEAGGS 

       250        260        270        280 
GAVVGRNIFQ RENPEPMIKA LIRVIHRNED PEEAAKAEGL L 

« Hide

References

« Hide 'large scale' references
[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
[2]"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
Gao J., Wang J.
Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ248283 Genomic DNA. Translation: CAB49012.1.
HE613800 Genomic DNA. Translation: CCE69464.1.
PIRE75195.
RefSeqNP_125781.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V2I6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272844.PAB0049.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB49012; CAB49012; PAB0049.
GeneID1494975.
KEGGpab:PAB0049.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1830.
HOGENOMHOG000224790.
KOK11645.
OMAEWKMFEE.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF038992. Aldolase_Ia. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALF1_PYRAB
AccessionPrimary (citable) accession number: Q9V2I6
Secondary accession number(s): G8ZFS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families