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Q9V2I6

- ALF1_PYRAB

UniProt

Q9V2I6 - ALF1_PYRAB

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Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulationi

Activated by citrate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fba
Ordered Locus Names:PYRAB00890
ORF Names:PAB0049
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138948Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB0049.

Structurei

3D structure databases

ProteinModelPortaliQ9V2I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiCOG1830.
HOGENOMiHOG000224790.
KOiK11645.
OMAiEWKMFEE.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V2I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEALQNIGIK RRLRRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV
60 70 80 90 100
IIRKVVRAGV DGVMMLPGMA RIAGDDVKPE VGLMIKITSK TNLRPKAEQL
110 120 130 140 150
MQSQLAFVED AIKLGADAIA ATVYWGSPQE DAMMRQFAEI VSYAHDLGFP
160 170 180 190 200
VVQFAYPRGP YIDEKYGRKE DYRVVMYGAR AAAEMGADMI KTYWTGSRET
210 220 230 240 250
FAKVVDAAAG VPVLLSGGAK AENPLDFLKV VYEVIEAGGS GAVVGRNIFQ
260 270 280
RENPEPMIKA LIRVIHRNED PEEAAKAEGL L
Length:281
Mass (Da):31,222
Last modified:May 1, 2000 - v1
Checksum:i6BFFCA8A4441D5A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49012.1.
HE613800 Genomic DNA. Translation: CCE69464.1.
PIRiE75195.
RefSeqiNP_125781.1. NC_000868.1.
WP_010867213.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49012; CAB49012; PAB0049.
GeneIDi1494975.
KEGGipab:PAB0049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49012.1 .
HE613800 Genomic DNA. Translation: CCE69464.1 .
PIRi E75195.
RefSeqi NP_125781.1. NC_000868.1.
WP_010867213.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V2I6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB0049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49012 ; CAB49012 ; PAB0049 .
GeneIDi 1494975.
KEGGi pab:PAB0049.

Phylogenomic databases

eggNOGi COG1830.
HOGENOMi HOG000224790.
KOi K11645.
OMAi EWKMFEE.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view ]
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiALF1_PYRAB
AccessioniPrimary (citable) accession number: Q9V2I6
Secondary accession number(s): G8ZFS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3