Q9V2I6 (ALF1_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13

Alternative name(s):
Fructose-biphosphate aldolase class I
Short name=FBP aldolase

Gene names

Name:	fba
Ordered Locus Names:	PYRAB00890
ORF Names:	PAB0049

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Enzyme regulation	Activated by citrate By similarity.
Subunit structure	Homooctamer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Fructose-bisphosphate aldolase class 1		PRO_0000138948
Sites
	Active site	191	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V2I6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6BFFCA8A4441D5A5	FASTA	281	31,222
	10 20 30 40 50 60 MEALQNIGIK RRLRRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV IIRKVVRAGV 70 80 90 100 110 120 DGVMMLPGMA RIAGDDVKPE VGLMIKITSK TNLRPKAEQL MQSQLAFVED AIKLGADAIA 130 140 150 160 170 180 ATVYWGSPQE DAMMRQFAEI VSYAHDLGFP VVQFAYPRGP YIDEKYGRKE DYRVVMYGAR 190 200 210 220 230 240 AAAEMGADMI KTYWTGSRET FAKVVDAAAG VPVLLSGGAK AENPLDFLKV VYEVIEAGGS 250 260 270 280 GAVVGRNIFQ RENPEPMIKA LIRVIHRNED PEEAAKAEGL L

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248283 Genomic DNA. Translation: CAB49012.1.
PIR	E75195.
RefSeq	NP_125781.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V2I6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002944; EBPYRP00000002875; EBPYRG00000002944.
GeneID	1494975.
GenomeReviews	Gene locus PYRAB00890 in contig AL096836_GR.
KEGG	pab:PAB0049.
NMPDR	fig|272844.1.peg.99.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022638.
HOGENOM	HBG553580.
OMA	RVIHRNE.
PhylomeDB	Q9V2I6.
ProtClustDB	PRK07226.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0049-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01623.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_PYRAB

Accession

Primary (citable) accession number: Q9V2I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program