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Q9V2I6

- ALF1_PYRAB

UniProt

Q9V2I6 - ALF1_PYRAB

Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Enzyme regulationi

    Activated by citrate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:PYRAB00890
    ORF Names:PAB0049
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138948Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi272844.PAB0049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V2I6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG1830.
    HOGENOMiHOG000224790.
    KOiK11645.
    OMAiEWKMFEE.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view]
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9V2I6-1 [UniParc]FASTAAdd to Basket

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    MEALQNIGIK RRLRRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV    50
    IIRKVVRAGV DGVMMLPGMA RIAGDDVKPE VGLMIKITSK TNLRPKAEQL 100
    MQSQLAFVED AIKLGADAIA ATVYWGSPQE DAMMRQFAEI VSYAHDLGFP 150
    VVQFAYPRGP YIDEKYGRKE DYRVVMYGAR AAAEMGADMI KTYWTGSRET 200
    FAKVVDAAAG VPVLLSGGAK AENPLDFLKV VYEVIEAGGS GAVVGRNIFQ 250
    RENPEPMIKA LIRVIHRNED PEEAAKAEGL L 281
    Length:281
    Mass (Da):31,222
    Last modified:May 1, 2000 - v1
    Checksum:i6BFFCA8A4441D5A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248283 Genomic DNA. Translation: CAB49012.1.
    HE613800 Genomic DNA. Translation: CCE69464.1.
    PIRiE75195.
    RefSeqiNP_125781.1. NC_000868.1.
    WP_010867213.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49012; CAB49012; PAB0049.
    GeneIDi1494975.
    KEGGipab:PAB0049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248283 Genomic DNA. Translation: CAB49012.1 .
    HE613800 Genomic DNA. Translation: CCE69464.1 .
    PIRi E75195.
    RefSeqi NP_125781.1. NC_000868.1.
    WP_010867213.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V2I6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB0049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49012 ; CAB49012 ; PAB0049 .
    GeneIDi 1494975.
    KEGGi pab:PAB0049.

    Phylogenomic databases

    eggNOGi COG1830.
    HOGENOMi HOG000224790.
    KOi K11645.
    OMAi EWKMFEE.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view ]
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiALF1_PYRAB
    AccessioniPrimary (citable) accession number: Q9V2I6
    Secondary accession number(s): G8ZFS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3