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Q9V253

- PUR1_PYRAB

UniProt

Q9V253 - PUR1_PYRAB

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Protein
Amidophosphoribosyltransferase
Gene
purF, PYRAB02210, PAB0151
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 4Fe-4S cluster per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111For GATase activity By similarity
Metal bindingi239 – 2391Iron-sulfur (4Fe-4S) By similarity
Metal bindingi286 – 2861Magnesium By similarity
Metal bindingi346 – 3461Magnesium By similarity
Metal bindingi347 – 3471Magnesium By similarity
Metal bindingi383 – 3831Iron-sulfur (4Fe-4S) By similarity
Metal bindingi432 – 4321Iron-sulfur (4Fe-4S) By similarity
Metal bindingi435 – 4351Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
  3. nucleoside metabolic process Source: InterPro
  4. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Amidophosphoribosyltransferase (EC:2.4.2.14)
Short name:
ATase
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Short name:
GPATase
Gene namesi
Name:purF
Ordered Locus Names:PYRAB02210
ORF Names:PAB0151
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1010 Inferred
PRO_0000029277
Chaini11 – 447437Amidophosphoribosyltransferase
PRO_0000029278Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0151.

Structurei

3D structure databases

ProteinModelPortaliQ9V253.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 224214Glutamine amidotransferase type-2
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0034.
HOGENOMiHOG000033688.
KOiK00764.
OMAiSGIPYEM.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V253-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVRGMREK CGIFGVSSED AVRKTYYGLI ALQHRGQEGA GISVWNGRIR    50
TIKGHGLVSE VFDENSLNLA SNIAIGHVRY STSGSLSEVQ PLEVRCCGYE 100
LAIAHNGTLT NFIPLRRLYE GMGIKFHSSV DTEVIGISFL NHYSQVKDEF 150
EAMRRVFEEV KGAYSILILF DGKIIAARDP VGFRPLVFGE GDGYYFASED 200
SALRMFGLET RDVLPGEVFV IDGESYESKV LAREKHAYCV FEYIYFARPD 250
STLNGINVYC ARYRMGVELA RESPAEGDVV IAVPDSGRTA ALGFAHESGI 300
PYMEGLIKNR YIGRTFIMPS GRGLKVKLKL SPVREVVNGK RVVLVDDSIV 350
RGTTMTRIVK MLRDAGAREV HVRIASPPIR YPCYMGIDIP TRHELIAAWR 400
SIEDIRKEIG ADSLAYLSIE GLKRAVGTKN LCMACLTGEY PEWAFNF 447
Length:447
Mass (Da):49,772
Last modified:May 1, 2000 - v1
Checksum:i94E0B221A8B3F5DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49145.1.
HE613800 Genomic DNA. Translation: CCE69597.1.
PIRiB75212.
RefSeqiNP_125914.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49145; CAB49145; PAB0151.
GeneIDi1495110.
KEGGipab:PAB0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49145.1 .
HE613800 Genomic DNA. Translation: CCE69597.1 .
PIRi B75212.
RefSeqi NP_125914.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB0151.

Protein family/group databases

MEROPSi C44.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49145 ; CAB49145 ; PAB0151 .
GeneIDi 1495110.
KEGGi pab:PAB0151.

Phylogenomic databases

eggNOGi COG0034.
HOGENOMi HOG000033688.
KOi K00764.
OMAi SGIPYEM.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiPUR1_PYRAB
AccessioniPrimary (citable) accession number: Q9V253
Secondary accession number(s): G8ZG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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