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Q9V249

- GLMS_PYRAB

UniProt

Q9V249 - GLMS_PYRAB

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei593 – 5931For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:PYRAB02250
    ORF Names:PAB2201
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135428Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272844.PAB2201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini280 – 420141SIS 1UniRule annotationAdd
    BLAST
    Domaini449 – 588140SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiSVFETQT.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9V249-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYIGP RKASPIIVEG LKRLEYRGYD SAGIATSHEG RILIKKGAGK    50
    IDELAKRLNF TDLPGNIGIG HTRWATHGIP NDTNAHPHTD CTGKIVVVHN 100
    GIIENFQELK EELLRQGHVF RSDTDTEVIA HLIEENLRIT GNFEDAFRLS 150
    LLRLRGSFAL VVMFADDPER LYIARKDSPL IIGIGNGEMF IASDIPAFLP 200
    YTRKAVFLDD GEYGVVSRNG FTVKDIITGK EKRKKVYEIQ WTLEMAEKGG 250
    YDHFMLKEIF EQPRAVKDAI YGNLEEVPKI AGLLSKYDRI IITGMGTSYH 300
    AALVGKYLIQ RFGKIPVLVE EASELRYEYE DILDNKTLLI AITQSGETAD 350
    TVAAMKLAKS KGSKVIGIVN VVGSLATRIA DATLYTHAGP EIGVAATKTY 400
    TTQLTVLLLL SLELGKMNGV DTTQVENTLP KLPELIDAGL KMNEKIKELA 450
    KSLNDRRDFF YIGRGISYPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA 500
    LIEEGVPVIG VAPSGKTFEK MLSNIEEAKA RGGFIITVGD DLRLHQVSNV 550
    FIRLPKVPEE VSPITYIVPL QLLAYHLAVL KGHNPDRPRN LAKSVTVE 598
    Length:598
    Mass (Da):65,874
    Last modified:January 23, 2007 - v3
    Checksum:iACFC93F2E21CEA3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248283 Genomic DNA. Translation: CAB49149.1.
    HE613800 Genomic DNA. Translation: CCE69601.1.
    PIRiF75212.
    RefSeqiNP_125918.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49149; CAB49149; PAB2201.
    GeneIDi1495114.
    KEGGipab:PAB2201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248283 Genomic DNA. Translation: CAB49149.1 .
    HE613800 Genomic DNA. Translation: CCE69601.1 .
    PIRi F75212.
    RefSeqi NP_125918.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB2201.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49149 ; CAB49149 ; PAB2201 .
    GeneIDi 1495114.
    KEGGi pab:PAB2201.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi SVFETQT.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiGLMS_PYRAB
    AccessioniPrimary (citable) accession number: Q9V249
    Secondary accession number(s): G8ZG60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3