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Q9V249

- GLMS_PYRAB

UniProt

Q9V249 - GLMS_PYRAB

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei593 – 5931For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PYRAB02250
ORF Names:PAB2201
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135428Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB2201.

Structurei

3D structure databases

ProteinModelPortaliQ9V249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini280 – 420141SIS 1UniRule annotationAdd
BLAST
Domaini449 – 588140SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSVFETQT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V249-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGYIGP RKASPIIVEG LKRLEYRGYD SAGIATSHEG RILIKKGAGK
60 70 80 90 100
IDELAKRLNF TDLPGNIGIG HTRWATHGIP NDTNAHPHTD CTGKIVVVHN
110 120 130 140 150
GIIENFQELK EELLRQGHVF RSDTDTEVIA HLIEENLRIT GNFEDAFRLS
160 170 180 190 200
LLRLRGSFAL VVMFADDPER LYIARKDSPL IIGIGNGEMF IASDIPAFLP
210 220 230 240 250
YTRKAVFLDD GEYGVVSRNG FTVKDIITGK EKRKKVYEIQ WTLEMAEKGG
260 270 280 290 300
YDHFMLKEIF EQPRAVKDAI YGNLEEVPKI AGLLSKYDRI IITGMGTSYH
310 320 330 340 350
AALVGKYLIQ RFGKIPVLVE EASELRYEYE DILDNKTLLI AITQSGETAD
360 370 380 390 400
TVAAMKLAKS KGSKVIGIVN VVGSLATRIA DATLYTHAGP EIGVAATKTY
410 420 430 440 450
TTQLTVLLLL SLELGKMNGV DTTQVENTLP KLPELIDAGL KMNEKIKELA
460 470 480 490 500
KSLNDRRDFF YIGRGISYPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA
510 520 530 540 550
LIEEGVPVIG VAPSGKTFEK MLSNIEEAKA RGGFIITVGD DLRLHQVSNV
560 570 580 590
FIRLPKVPEE VSPITYIVPL QLLAYHLAVL KGHNPDRPRN LAKSVTVE
Length:598
Mass (Da):65,874
Last modified:January 23, 2007 - v3
Checksum:iACFC93F2E21CEA3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49149.1.
HE613800 Genomic DNA. Translation: CCE69601.1.
PIRiF75212.
RefSeqiNP_125918.1. NC_000868.1.
WP_010867349.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49149; CAB49149; PAB2201.
GeneIDi1495114.
KEGGipab:PAB2201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49149.1 .
HE613800 Genomic DNA. Translation: CCE69601.1 .
PIRi F75212.
RefSeqi NP_125918.1. NC_000868.1.
WP_010867349.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB2201.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49149 ; CAB49149 ; PAB2201 .
GeneIDi 1495114.
KEGGi pab:PAB2201.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi SVFETQT.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiGLMS_PYRAB
AccessioniPrimary (citable) accession number: Q9V249
Secondary accession number(s): G8ZG60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3