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Q9V249

- GLMS_PYRAB

UniProt

Q9V249 - GLMS_PYRAB

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, PYRAB02250, PAB2201
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei593 – 5931For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PYRAB02250
ORF Names:PAB2201
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000810: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135428Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272844.PAB2201.

Structurei

3D structure databases

ProteinModelPortaliQ9V249.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini280 – 420141SIS 1
Add
BLAST
Domaini449 – 588140SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSVFETQT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9V249-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGYIGP RKASPIIVEG LKRLEYRGYD SAGIATSHEG RILIKKGAGK    50
IDELAKRLNF TDLPGNIGIG HTRWATHGIP NDTNAHPHTD CTGKIVVVHN 100
GIIENFQELK EELLRQGHVF RSDTDTEVIA HLIEENLRIT GNFEDAFRLS 150
LLRLRGSFAL VVMFADDPER LYIARKDSPL IIGIGNGEMF IASDIPAFLP 200
YTRKAVFLDD GEYGVVSRNG FTVKDIITGK EKRKKVYEIQ WTLEMAEKGG 250
YDHFMLKEIF EQPRAVKDAI YGNLEEVPKI AGLLSKYDRI IITGMGTSYH 300
AALVGKYLIQ RFGKIPVLVE EASELRYEYE DILDNKTLLI AITQSGETAD 350
TVAAMKLAKS KGSKVIGIVN VVGSLATRIA DATLYTHAGP EIGVAATKTY 400
TTQLTVLLLL SLELGKMNGV DTTQVENTLP KLPELIDAGL KMNEKIKELA 450
KSLNDRRDFF YIGRGISYPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA 500
LIEEGVPVIG VAPSGKTFEK MLSNIEEAKA RGGFIITVGD DLRLHQVSNV 550
FIRLPKVPEE VSPITYIVPL QLLAYHLAVL KGHNPDRPRN LAKSVTVE 598
Length:598
Mass (Da):65,874
Last modified:January 23, 2007 - v3
Checksum:iACFC93F2E21CEA3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49149.1.
HE613800 Genomic DNA. Translation: CCE69601.1.
PIRiF75212.
RefSeqiNP_125918.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49149; CAB49149; PAB2201.
GeneIDi1495114.
KEGGipab:PAB2201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ248283 Genomic DNA. Translation: CAB49149.1 .
HE613800 Genomic DNA. Translation: CCE69601.1 .
PIRi F75212.
RefSeqi NP_125918.1. NC_000868.1.

3D structure databases

ProteinModelPortali Q9V249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272844.PAB2201.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB49149 ; CAB49149 ; PAB2201 .
GeneIDi 1495114.
KEGGi pab:PAB2201.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi SVFETQT.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GE5 / Orsay.
  2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
    Gao J., Wang J.
    Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GE5 / Orsay.

Entry informationi

Entry nameiGLMS_PYRAB
AccessioniPrimary (citable) accession number: Q9V249
Secondary accession number(s): G8ZG60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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