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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 149ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Gene namesi
Name:radA
Ordered Locus Names:PYRAB02410
ORF Names:PAB0164
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501021 – 353DNA repair and recombination protein RadAAdd BLAST353

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0164.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK04483.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKSSDPAV VEINDVDELE LEVGEEVTSK KKKKEKEIRT IEDLPGVGPA
60 70 80 90 100
TAEKLREAGF DTLEAIAVAS PIELKEVAGI SEGAALKIIQ AARKAANLGT
110 120 130 140 150
FMRADEYLKK RESIGRISTG SKSLDKLLGG GIETQAITEV FGEFGSGKTQ
160 170 180 190 200
LAHTLAVMVQ LPPEEGGLNG SVIWIDTENT FRPERIREIA KNRGLDPDEV
210 220 230 240 250
LKHIYVARAF NSNHQMLLVQ QAEDKIKELL NTDKPVKLLI VDSLTSHFRS
260 270 280 290 300
EYIGRGALAE RQQKLAKHLA DLHRLANLYE IAVFVTNQVQ ARPDAFFGDP
310 320 330 340 350
TRPIGGHILA HSATLRVYLR KGKGGKRVAR LIDAPHLPEG EAVFRITEKG

IED
Length:353
Mass (Da):38,760
Last modified:May 16, 2012 - v2
Checksum:i254E7D1C440BAB13
GO

Sequence cautioni

The sequence CAB49165 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248283 Genomic DNA. Translation: CAB49165.1. Different initiation.
HE613800 Genomic DNA. Translation: CCE69617.1.
PIRiF75214.
RefSeqiWP_048146514.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49165; CAB49165; PAB0164.
GeneIDi1495130.
KEGGipab:PAB0164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248283 Genomic DNA. Translation: CAB49165.1. Different initiation.
HE613800 Genomic DNA. Translation: CCE69617.1.
PIRiF75214.
RefSeqiWP_048146514.1. NC_000868.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49165; CAB49165; PAB0164.
GeneIDi1495130.
KEGGipab:PAB0164.

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK04483.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADA_PYRAB
AccessioniPrimary (citable) accession number: Q9V233
Secondary accession number(s): G8ZG76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 16, 2012
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.