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Q9V207 (GLPK_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:PYRAB02670
ORF Names:PAB2406
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Glycerol kinase HAMAP MF_00186
PRO_0000059528

Regions

Nucleotide binding403 – 4075ATP By similarity

Sites

Binding site151Substrate By similarity
Binding site191ATP By similarity
Binding site851Substrate By similarity
Binding site1351Substrate By similarity
Binding site2401Substrate By similarity
Binding site2621ATP By similarity
Binding site3041ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9V207 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D868694AF74E8CC8

FASTA49455,693
        10         20         30         40         50         60 
MSPVEGYILS LDEGTTSARA IVFDREGNIK GIGQYEFPQY YPKPGWVEHN PMEIWDAQVR 

        70         80         90        100        110        120 
AIKTAIQKAK VEPAQIKAIG ITNQRETTIV WDKNGNPLYN AIVWQCRRTA EMVEEIKREY 

       130        140        150        160        170        180 
GDLIKEKTGL IPDAYFSASK IRWLLDNVPR LREKAERGEV LFGTVDSFLI YKLTGEHVTD 

       190        200        210        220        230        240 
YSNASRTMLF NIKKLDWDEE LLEIFKIPEG ILPEVRESSE IYGYTRILGN EIPVSGDAGD 

       250        260        270        280        290        300 
QQAALFGQAG FETGMVKATY GTGNFILVNT GKTVRYSENL LTTIAWGLDG KVTYALEGSI 

       310        320        330        340        350        360 
FITGAAVQWL RDGIKIIKHA SETEDLAEKL ESNEGVYFVP AFVGLGAPYW DQFARGLIIG 

       370        380        390        400        410        420 
ITRGTGREHL ARATLEAIAY LTRDVIEEME KLVGIKELRV DGGATANDFL MQFQADILNR 

       430        440        450        460        470        480 
RVVRPVVKET TALGAAYLAG LAVDYWESLE EIESLWRVEK IFEPRMDEET REKLYRGWKE 

       490 
AVKRAMGWAK VISS

« Hide

References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ248283 Genomic DNA. Translation: CAB49191.1.
PIRH75217.
RefSeqNP_125960.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V207.
SMRQ9V207. Positions 4-494.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000003190; EBPYRP00000003121; EBPYRG00000003190.
GeneID1495157.
GenomeReviewsGene locus PYRAB02670 in contig AL096836_GR.
KEGGpab:PAB2406.
NMPDRfig|272844.1.peg.281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022271.
HOGENOMHBG511469.
OMAFHWSINA.
PhylomeDBQ9V207.
ProtClustDBPRK00047.

Enzyme and pathway databases

BioCycPABY272844:PAB2406-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_PYRAB
AccessionPrimary (citable) accession number: Q9V207
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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