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Protein

Probable ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei25S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei50S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei71S-adenosyl-L-methionineUniRule annotation1
Binding sitei95S-adenosyl-L-methionineUniRule annotation1
Binding sitei110S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:PYRAB03790
ORF Names:PAB0253
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001016611 – 269Probable ribosomal RNA small subunit methyltransferase AAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0253.

Structurei

3D structure databases

ProteinModelPortaliQ9V1P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04131. Archaea.
COG0030. LUCA.
HOGENOMiHOG000227962.
KOiK02528.
OMAiYNADVEF.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V1P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDRLFFLLS KYGIRPNDRI GQHFLIVKDV IDKAIEVAEV SKSDVVLEVG
60 70 80 90 100
PGLGFLTDEL SKRAKKVFTI ELDRRIIEIL RNEYSWNNVE IIQGDAVKVE
110 120 130 140 150
WPSFNKVVSN IPYQISSPFT FKLLKMEFER AVVMYQLEFA LRMTAKPGDR
160 170 180 190 200
NYSRLSLMTQ ALADVEIVMR IGKGAFYPKP KVDSALVLIT PKKDRIELNE
210 220 230 240 250
SLVKALFQHR RKVVSKALRE SAHMLGIKDV KTVKDILSSV PHSNKRVFHL
260
TPEEVKEIEE YLREHRIIS
Length:269
Mass (Da):31,081
Last modified:May 1, 2000 - v1
Checksum:i017776D908709663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49301.1.
HE613800 Genomic DNA. Translation: CCE69756.1.
PIRiF75152.
RefSeqiWP_010867501.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49301; CAB49301; PAB0253.
GeneIDi1495269.
KEGGipab:PAB0253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49301.1.
HE613800 Genomic DNA. Translation: CCE69756.1.
PIRiF75152.
RefSeqiWP_010867501.1. NC_000868.1.

3D structure databases

ProteinModelPortaliQ9V1P8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49301; CAB49301; PAB0253.
GeneIDi1495269.
KEGGipab:PAB0253.

Phylogenomic databases

eggNOGiarCOG04131. Archaea.
COG0030. LUCA.
HOGENOMiHOG000227962.
KOiK02528.
OMAiYNADVEF.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSMA_PYRAB
AccessioniPrimary (citable) accession number: Q9V1P8
Secondary accession number(s): G8ZI13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.