Q9V1P5 (XERCL_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tyrosine recombinase XerC-like

Gene names

Ordered Locus Names:	PYRAB03820
ORF Names:	PAB0255

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules By similarity. HAMAP-Rule MF_01808
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerC subfamily.

Ontologies

Keywords
Biological process	DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	chromosome segregation Inferred from electronic annotation. Source: HAMAP transposition, DNA-mediated Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW tyrosine-based site-specific recombinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 286

286

Probable tyrosine recombinase XerC-like HAMAP-Rule MF_01808

PRO_0000095355

Sites

Active site

135

1

By similarity

Active site

160

1

By similarity

Active site

226

1

By similarity

Active site

229

1

By similarity

Active site

252

1

By similarity

Active site

261

1

O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Secondary structure

1

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286

Helix Strand Turn

Details...

Helix

11 – 22

12

Helix

27 – 43

17

Helix

49 – 62

14

Helix

66 – 83

18

Helix

86 – 91

6

Helix

107 – 115

9

Helix

120 – 131

12

Helix

136 – 141

6

Helix

144 – 146

3

Turn

149 – 152

4

Beta strand

153 – 156

4

Beta strand

160 – 162

3

Beta strand

165 – 168

4

Helix

171 – 182

12

Beta strand

189 – 191

3

Beta strand

200 – 202

3

Helix

205 – 218

14

Helix

225 – 238

14

Helix

243 – 250

8

Helix

265 – 272

8

Turn

273 – 278

6

Sequences

	Sequence		Length	Mass (Da)
	Q9V1P5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C44A99CB3F75A0E2	FASTA	286	33,025
	10 20 30 40 50 60 MEEREERVRD DTIEEFATYL ELEGKSRNTV RMYTYYISKF FEEGHSPTAR DALRFLAKLK 70 80 90 100 110 120 RKGYSTRSLN LVIQALKAYF KFEGLDSEAE KLKTPKMPKT LPKSLTEEEV RRIINAAETL 130 140 150 160 170 180 RDRLILLLLY GAGLRVSELC NLRVEDVNFE YGVIVVRGGK GGKDRVVPIS ESLLSEIKRY 190 200 210 220 230 240 LESRNDDSPY LFVEMKRKRK DKLSPKTVWR LVKKYGRKAG VELTPHQLRH SFATHMLERG 250 260 270 280 IDIRIIQELL GHSNLSTTQI YTKVSTKHLK EAVKKAKLVE SIIGGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ248284 Genomic DNA. Translation: CAB49304.1.
HE613800 Genomic DNA. Translation: CCE69759.1.

PIR

A75153.

RefSeq

NP_126073.1. NC_000868.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4A8E	X-ray	2.99	A	1-286	[»]

ProteinModelPortal

Q9V1P5.

ModBase

Search...

Protein-protein interaction databases

STRING

272844.PAB0255.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

CAB49304; CAB49304; PAB0255.

GeneID

1495272.

KEGG

pab:PAB0255.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0582.

HOGENOM

HOG000045296.

KO

K04763.

OMA

ARNHPPL.

ProtClustDB

CLSK340523.

Family and domain databases

Gene3D

1.10.150.130. 1 hit.
1.10.443.10. 1 hit.

HAMAP

MF_01808. Recomb_XerC.

InterPro

IPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]

Pfam

PF02899. Phage_integr_N. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]

SUPFAM

SSF56349. DNA_brk_join_enz. 1 hit.

ProtoNet

Search...

Entry information

Entry name

XERCL_PYRAB

Accession

Primary (citable) accession number: Q9V1P5
Secondary accession number(s): G8ZI16

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program