Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine recombinase XerA

Gene

xerA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Probably involved in the resolution of chromosome dimers at the terminus of replication. Binds to the dif site.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135UniRule annotationBy similarity1 Publication1
Active sitei160UniRule annotationBy similarity1
Active sitei226UniRule annotationBy similarity1
Active sitei229UniRule annotationBy similarity1
Active sitei252UniRule annotationBy similarity1
Active sitei261O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotationBy similarity1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerAUniRule annotationCurated
Gene namesi
Name:xerA1 PublicationUniRule annotation
Ordered Locus Names:PYRAB03820
ORF Names:PAB0255
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationCurated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135R → A: Lack of recombinase activity. 1 Publication1
Mutagenesisi261Y → F: Lack of recombinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000953551 – 286Tyrosine recombinase XerAAdd BLAST286

Interactioni

Subunit structurei

Homodimer in the absence of DNA substrate.1 Publication

Protein-protein interaction databases

STRINGi272844.PAB0255.

Structurei

Secondary structure

1286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 22Combined sources12
Helixi27 – 43Combined sources17
Helixi49 – 62Combined sources14
Helixi66 – 83Combined sources18
Helixi86 – 91Combined sources6
Helixi107 – 115Combined sources9
Helixi120 – 131Combined sources12
Helixi136 – 141Combined sources6
Helixi144 – 146Combined sources3
Turni149 – 152Combined sources4
Beta strandi153 – 156Combined sources4
Beta strandi160 – 162Combined sources3
Beta strandi165 – 168Combined sources4
Helixi171 – 182Combined sources12
Beta strandi189 – 191Combined sources3
Beta strandi200 – 202Combined sources3
Helixi205 – 218Combined sources14
Helixi225 – 238Combined sources14
Helixi243 – 250Combined sources8
Helixi265 – 272Combined sources8
Turni273 – 278Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A8EX-ray2.99A1-286[»]
ProteinModelPortaliQ9V1P5.
SMRiQ9V1P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerA subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiarCOG01241. Archaea.
COG0582. LUCA.
HOGENOMiHOG000045296.
KOiK04763.
OMAiTKVTVEH.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_02055. Recomb_XerA. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR010998. Integrase_Lambda-type_N.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR033686. XerA.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF47823. SSF47823. 1 hit.
SSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9V1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEREERVRD DTIEEFATYL ELEGKSRNTV RMYTYYISKF FEEGHSPTAR
60 70 80 90 100
DALRFLAKLK RKGYSTRSLN LVIQALKAYF KFEGLDSEAE KLKTPKMPKT
110 120 130 140 150
LPKSLTEEEV RRIINAAETL RDRLILLLLY GAGLRVSELC NLRVEDVNFE
160 170 180 190 200
YGVIVVRGGK GGKDRVVPIS ESLLSEIKRY LESRNDDSPY LFVEMKRKRK
210 220 230 240 250
DKLSPKTVWR LVKKYGRKAG VELTPHQLRH SFATHMLERG IDIRIIQELL
260 270 280
GHSNLSTTQI YTKVSTKHLK EAVKKAKLVE SIIGGS
Length:286
Mass (Da):33,025
Last modified:May 1, 2000 - v1
Checksum:iC44A99CB3F75A0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49304.1.
HE613800 Genomic DNA. Translation: CCE69759.1.
PIRiA75153.
RefSeqiWP_010867504.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49304; CAB49304; PAB0255.
GeneIDi1495272.
KEGGipab:PAB0255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49304.1.
HE613800 Genomic DNA. Translation: CCE69759.1.
PIRiA75153.
RefSeqiWP_010867504.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A8EX-ray2.99A1-286[»]
ProteinModelPortaliQ9V1P5.
SMRiQ9V1P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49304; CAB49304; PAB0255.
GeneIDi1495272.
KEGGipab:PAB0255.

Phylogenomic databases

eggNOGiarCOG01241. Archaea.
COG0582. LUCA.
HOGENOMiHOG000045296.
KOiK04763.
OMAiTKVTVEH.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_02055. Recomb_XerA. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR010998. Integrase_Lambda-type_N.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR033686. XerA.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF47823. SSF47823. 1 hit.
SSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXERA_PYRAB
AccessioniPrimary (citable) accession number: Q9V1P5
Secondary accession number(s): G8ZI16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.