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Reviewed, UniProtKB/Swiss-Prot Q9V1P1 (G3P_PYRAB)

Last modified November 3, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glyceraldehyde-3-phosphate dehydrogenase
      Short name=GAPDH
    EC=1.2.1.59
Alternative name(s):
    NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene names
Name: gap
Ordered Locus Names: PYRAB03860
ORF Names: PAB0257
OrganismPyrococcus abyssi [Complete proteome] [HAMAP]
Taxonomic identifier29292 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. HAMAP MF_00559

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. HAMAP MF_00559

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Glyceraldehyde-3-phosphate dehydrogenase HAMAP MF_00559
PRO_0000145728

Regions

Nucleotide binding12 – 132NAD By similarity
Region140 – 1423Glyceraldehyde 3-phosphate binding By similarity
Region192 – 1932Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1411Nucleophile By similarity
Binding site1111NAD; via amide nitrogen By similarity
Binding site1671NAD By similarity
Binding site2981NAD; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9V1P1-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2251623272603295

FASTA33437,251
        10         20         30         40         50         60 
MKVKVGVNGY GTIGKRVAYA ITKQDDMELV GVVKTKPDFE AYRAKELGIP VYAANEEFLS 

        70         80         90        100        110        120 
RFESVGFEVE GTLNDLLEKV DVIVDATPGG VGAKNKPLYE KAGVKAVFQG GEKANVAEVS 

       130        140        150        160        170        180 
FVAQANYEKA LGKSYVRVVS CNTTGLVRTL NAIREYADYV YAVMIRRAAD PNDIKRGPIN 

       190        200        210        220        230        240 
AIKPSVEVPS HHGPDVQTVI PINIETMAFV VPTTIMHVHS VMVELKKPLT REDVIDIFEN 

       250        260        270        280        290        300 
TTRVLLFEKE KGFESTAQII EFARDLHREW NNLYEIAVWK ESINVKGNRL YYIQAVHQES 

       310        320        330 
DVVPENVDAI RAMFELADKE ESIKKTNKSL GILK

« Hide

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References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

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Cross-references

Sequence databases

AJ248284 Genomic DNA. Translation: CAB49308.1.
PIRE75153.
RefSeqNP_126077.1.

3D structure databases

HSSPHSSP built from PDB template 1CF2 based on UniProtKB P10618.
SMRQ9V1P1. Positions 1-334.
ModBaseSearch...

Genome annotation databases

GeneID1495277.
GenomeReviewsGene locus PYRAB03860 in contig AL096836_GR.
KEGGpab:PAB0257.
NMPDRfig|272844.1.peg.401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9V1P1.
OMAAIFQGGE.

Enzyme and pathway databases

BioCycPABY272844:PAB0257-MON.
BRENDA1.2.1.59. 262861.

Family and domain databases

HAMAPMF_00559.
[Tree]
InterProIPR000846. DapB.
IPR000173. GlycerAld_3-P_DH.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10836. GAP_DH. 1 hit.
PfamPF01113. DapB_N. 1 hit.
PF02800. Gp_dh_C. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
ProDomPD004105. DapB. 1 hit.
PD007761. GAPDH_like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameG3P_PYRAB
AccessionPrimary (citable) accession number: Q9V1P1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 3, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents