Reviewed, UniProtKB/Swiss-Prot Q9V1N8 (THIL_PYRAB)

Names and origin

Protein names

Recommended name:
    Probable thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	PYRAB03890
ORF Names:	PAB2358

Organism

Pyrococcus abyssi [Complete proteome] [HAMAP]

Taxonomic identifier

29292 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Probable thiamine-monophosphate kinase		PRO_0000096203

Sequences

	Sequence		Length	Mass (Da)
	Q9V1N8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9717B8FC1667FADE	FASTA	310	34,126
	10 20 30 40 50 60 MVVSMREGEI ISLFMKHFER HSLGDDAGFI KLNNSWLLVT SDMLVWKTDV PDFMTPEDAG 70 80 90 100 110 120 RKVVTMNVSD IAAMGGRPMA FFFSLAVPGD VSEDILRGIA RGINEGSKVY KLKIVSGDTN 130 140 150 160 170 180 EADDIIIDGG SLGIGKRLLL RSNAKPGDLV CVTGDLGRPL TALLLWMRGE KIPREIEEKA 190 200 210 220 230 240 RNPRARVEEG VKLSSLANSA IDISDGLSKE LWEIANASNV RIIIEEERLP ISDSVKEIVS 250 260 270 280 290 300 DPVKVALASG EEFELLFTIP REKVEELDID FKIIGRVEGG NGVYIKRGRK IEELEVLGWE 310 HLAGGIDVEL

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49311.1.
PIR	H75153.
RefSeq	NP_126080.1.
3D structure databases
SMR	Q9V1N8. Positions 4-292.
ModBase	Search...
Genome annotation databases
GeneID	1495280.
KEGG	pab:PAB2358.
NMPDR	fig|272844.1.peg.404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG577902.
OMA	ANVSDIA.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2358-MONOMER.
BRENDA	2.7.4.16. 262861.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_PYRAB

Accession

Primary (citable) accession number: Q9V1N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)