Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9V1N8 (THIL_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable thiamine-monophosphate kinase

Short name=Thiamine-phosphate kinase
EC=2.7.4.16
Gene names
Name:thiL
Ordered Locus Names:PYRAB03890
ORF Names:PAB2358
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thiamine phosphate = ADP + thiamine diphosphate.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.

Sequence similarities

Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
   Biological processThiamine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthiamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thiamine-phosphate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Probable thiamine-monophosphate kinase
PRO_0000096203

Sequences

Sequence LengthMass (Da)Tools
Q9V1N8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 9717B8FC1667FADE

FASTA31034,126
        10         20         30         40         50         60 
MVVSMREGEI ISLFMKHFER HSLGDDAGFI KLNNSWLLVT SDMLVWKTDV PDFMTPEDAG 

        70         80         90        100        110        120 
RKVVTMNVSD IAAMGGRPMA FFFSLAVPGD VSEDILRGIA RGINEGSKVY KLKIVSGDTN 

       130        140        150        160        170        180 
EADDIIIDGG SLGIGKRLLL RSNAKPGDLV CVTGDLGRPL TALLLWMRGE KIPREIEEKA 

       190        200        210        220        230        240 
RNPRARVEEG VKLSSLANSA IDISDGLSKE LWEIANASNV RIIIEEERLP ISDSVKEIVS 

       250        260        270        280        290        300 
DPVKVALASG EEFELLFTIP REKVEELDID FKIIGRVEGG NGVYIKRGRK IEELEVLGWE 

       310 
HLAGGIDVEL 

« Hide

References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ248284 Genomic DNA. Translation: CAB49311.1.
PIRH75153.
RefSeqNP_126080.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V1N8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000002340; EBPYRP00000002271; EBPYRG00000002340.
GeneID1495280.
GenomeReviewsGene locus PYRAB03890 in contig AL096836_GR.
KEGGpab:PAB2358.
NMPDRfig|272844.1.peg.404.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022555.
HOGENOMHBG577902.
OMAFFGEDFE.
PhylomeDBQ9V1N8.
ProtClustDBPRK05731.

Enzyme and pathway databases

BioCycPABY272844:PAB2358-MONOMER.

Family and domain databases

InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR016188. PurM_N-like.
IPR006283. ThiL.
[Graphical view]
KOK00946.
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
PIRSFPIRSF005303. Thiam_monoph_kin. 1 hit.
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR01379. ThiL. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIL_PYRAB
AccessionPrimary (citable) accession number: Q9V1N8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families