Q9V1J1 (HOSA_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative homocitrate synthase
EC=2.3.3.14

Gene names

Ordered Locus Names:	PYRAB04360
ORF Names:	PAB0286

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + H2O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA.
Sequence similarities	Belongs to the alpha-IPM synthase/homocitrate synthase family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	homocitrate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Putative homocitrate synthase		PRO_0000140419

Sequences

	Sequence		Length	Mass (Da)
	Q9V1J1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C8667A7459954476	FASTA	361	40,827
	10 20 30 40 50 60 MVLDSTLREG EQTPGVNYTP EQRLEIAIAL DEVGVDFIEI GHPAVSEDVF RGMKLIAEQG 70 80 90 100 110 120 LNVELLAHSR ALIEDIDYVL KTGVDWVGIF FCLSEACLRK RFRITLDHAL EKISRAIEYA 130 140 150 160 170 180 KDHGLKVRFT PEDTTRTEWA NLKRAIRLAK ELKVDRISVA DTTGSTHPLR FYTLVKKIVN 190 200 210 220 230 240 FGIPVNVHCH NDLGLALANA IMGIEAGATL VDATVNGLGE RAGIVDLAQI ITVLYYHYGI 250 260 270 280 290 300 KKYRLDLLYR VSNLVSEITG ISPQPNYPIV GENAFTHKAG LHVSAVLKDP RFYEFLPAEV 310 320 330 340 350 360 FGRERTIYVD RYAGKDTIRY YLEKFGIRDH GIVTSLLRKV KSSREPFTWE KLLEEARRVK E

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49358.1.
PIR	G75159.
RefSeq	NP_126127.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1J1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002637; EBPYRP00000002568; EBPYRG00000002637.
GeneID	1495330.
GenomeReviews	Gene locus PYRAB04360 in contig AL096836_GR.
KEGG	pab:PAB0286.
NMPDR	fig|272844.1.peg.454.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022307.
HOGENOM	HBG701974.
OMA	YTTSVAR.
PhylomeDB	Q9V1J1.
ProtClustDB	PRK11858.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0286-MONOMER.
Family and domain databases
InterPro	IPR002034. AIPM/Hcit_synth_CS. IPR013785. Aldolase_TIM. IPR011872. Homocitrate_synth_fun/arc. IPR000891. PYR_CT. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01649.
Pfam	PF00682. HMGL-like. 1 hit. [Graphical view]
TIGRFAMs	TIGR02146. LysS_fung_arch. 1 hit.
PROSITE	PS00815. AIPM_HOMOCIT_SYNTH_1. False negative. PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit. PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOSA_PYRAB

Accession

Primary (citable) accession number: Q9V1J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program