Q9V1I6 (ARGC_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase
Short name=AGPR
EC=1.2.1.-
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Synonyms:	lysY
Ordered Locus Names:	PYRAB04410
ORF Names:	PAB0291

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_00150
Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase HAMAP MF_00150		PRO_0000112492
Sites
	Active site	142	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V1I6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CECC9E2AC23D4C8F	FASTA	330	36,962
	10 20 30 40 50 60 MIKAAIVGGS GYIGGELIRL LSMHPEVEIT TITSRKFAGK KVHKVHPNLR GLNLRFTDKY 70 80 90 100 110 120 EFDADVIFLA VPHGTSMRII GEFLGSAKII DLSADFRVSK DLYEKYYGSH EKPELIDKFV 130 140 150 160 170 180 YGLPELHRKE IKRAELVANP GCNATAVILA LYPFRDVTSE AIVDLKVSSS AGGRRENVAS 190 200 210 220 230 240 IHPERSHVVR VYKPFHHRHE AEVLQETGVK AMFTVHSVDI VRGLLATTYF KFEGSEKDLL 250 260 270 280 290 300 KRLLMYRGEP FIRLVTDKGG LQRYPDPKYV IGSNFVDIGF SYDSENSRAI VFSALDNLIK 310 320 330 GGAGQAVQNM NIMFGFDETL GLNYYPLYPG

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49363.1.
PIR	D75160.
RefSeq	NP_126132.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1I6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003226; EBPYRP00000003157; EBPYRG00000003226.
GeneID	1495336.
GenomeReviews	Gene locus PYRAB04410 in contig AL096836_GR.
KEGG	pab:PAB0291.
NMPDR	fig|272844.1.peg.460.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022773.
HOGENOM	HBG294213.
OMA	VYRYPEP.
PhylomeDB	Q9V1I6.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0291-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_PYRAB

Accession

Primary (citable) accession number: Q9V1I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program