Q9V1I5 (ARGB_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate/acetylaminoadipate kinase
EC=2.7.2.-
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Synonyms:	lysZ
Ordered Locus Names:	PYRAB04420
ORF Names:	PAB0292

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_00082_A
Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_A ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP MF_00082_A
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_A Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP MF_00082_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_A.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Acetylglutamate/acetylaminoadipate kinase HAMAP MF_00082_A		PRO_0000112699
Regions
	Region	36 – 37	2	Substrate binding By similarity
Sites
	Binding site	63	1	Substrate By similarity
	Binding site	165	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	221	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V1I5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7920CC2A83AF2B1D	FASTA	248	27,238
	10 20 30 40 50 60 MIQMRVIKVG GSVVPMLDKI LDTSSLHGNS IIVHGGSRYV DEMARKLGVK VERLVSPSGV 70 80 90 100 110 120 MFRRTTRRVL DVYVAALMRA NRELVSFLRE RGIDAIGVSG LDGVVLAKRK KLVKAVVNGK 130 140 150 160 170 180 VIAIRDDYSG VIKSINVTLL KNYLKVGIPV IASIAYDPEE NVPLNVDGDK VAYHVAIAMK 190 200 210 220 230 240 AKELRFLSDT AFLIDGNVVE RIPLEDFDEY LRYAGGGMKK KLMMARKALE SGVKKVVIEG LNGRTVIS

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49364.1.
PIR	E75160.
RefSeq	NP_126133.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1I5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003833; EBPYRP00000003764; EBPYRG00000003833.
GeneID	1495337.
GenomeReviews	Gene locus PYRAB04420 in contig AL096836_GR.
KEGG	pab:PAB0292.
NMPDR	fig|272844.1.peg.461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022350.
HOGENOM	HBG497643.
OMA	RYTDLET.
PhylomeDB	Q9V1I5.
ProtClustDB	PRK14058.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0292-MONOMER.
Family and domain databases
HAMAP	MF_00082_A. ArgB_A. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_PYRAB

Accession

Primary (citable) accession number: Q9V1I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program