Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9V1H9 (AROB_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:PYRAB04480
ORF Names:PAB0298
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3383383-dehydroquinate synthase HAMAP MF_00110
PRO_0000140817

Sequences

Sequence LengthMass (Da)Tools
Q9V1H9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 58C3B578CFD66353

FASTA33837,589
        10         20         30         40         50         60 
MEGIAHMENI IFSPLSSLPS IVEELNPYKI AVLTNDMLKS LWLDKIIELL GGDVFPIVIP 

        70         80         90        100        110        120 
DGEEYKTIET AIKIWDELVS FGFTRKSLLI GLGGGVITDI AGFVASTYMR GTLLGFIPTT 

       130        140        150        160        170        180 
LLAQVDAAIG GKTGVNFHGK NMIGTFYLPN FVLISTETLS TLPRIELLNG MAEVIKYAIL 

       190        200        210        220        230        240 
DKNVYRLLQD VKNVEEIRNR EDIIRESVNV KVRVVEEDLK ESGKRRILNL GHTVGHAIEK 

       250        260        270        280        290        300 
LSGYKIKHGF AVSVGLIAAA KLGEKLYNFD SGKVIELVER FNLPTKLPYP PKDIIEAMKL 

       310        320        330 
DKKAWYGKIV FVIPVEIGRI SIEDVPEELL LQVLGEIR

« Hide

References

[1]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ248284 Genomic DNA. Translation: CAB49370.1.
PIRC75161.
RefSeqNP_126139.1. NC_000868.1.

3D structure databases

ProteinModelPortalQ9V1H9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000002861; EBPYRP00000002792; EBPYRG00000002861.
GeneID1495344.
GenomeReviewsGene locus PYRAB04480 in contig AL096836_GR.
KEGGpab:PAB0298.
NMPDRfig|272844.1.peg.468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022389.
HOGENOMHBG632303.
OMAGTFTQPD.
PhylomeDBQ9V1H9.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPABY272844:PAB0298-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PYRAB
AccessionPrimary (citable) accession number: Q9V1H9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents