Q9V1H8 (AROD_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	PYRAB04490
ORF Names:	PAB0299

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138833
Sites
	Active site	112	1	Proton acceptor By similarity
	Active site	139	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V1H8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 02CC027484DB85D1	FASTA	215	24,510
	10 20 30 40 50 60 MIATVILADS IKEAIEKIKS SSSDLYELRA DSLKDYSKLE LLEPYSEKLV VTIRSKDEGG 70 80 90 100 110 120 FKELSDEKRL ELYSKFLEIK PRYVDVEFRS KIKDEVMEIA KRVGSRVILS YHNFRETPPF 130 140 150 160 170 180 GVLYNLLEDM ESEGADIVKI VTHASSPKDN IRIIRLYEFA DNLIAFCMGS KGKISRIFSS 190 200 210 MYSPITYVAL DKKAAPGQLT LEELRVILKI LGEGR

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49371.1.
PIR	D75161.
RefSeq	NP_126140.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1H8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002596; EBPYRP00000002527; EBPYRG00000002596.
GeneID	1495345.
GenomeReviews	Gene locus PYRAB04490 in contig AL096836_GR.
KEGG	pab:PAB0299.
NMPDR	fig|272844.1.peg.469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022269.
HOGENOM	HBG732926.
OMA	SYHNFDE.
PhylomeDB	Q9V1H8.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0299-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_PYRAB

Accession

Primary (citable) accession number: Q9V1H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program