Q9V1H7 (AROE_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	PYRAB04500
ORF Names:	PAB0300

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136065
Regions
	Nucleotide binding	122 – 126	5	NADP By similarity
Sites
	Active site	63	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9V1H7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BBFF9BEDC89CE725	FASTA	264	28,991
	10 20 30 40 50 60 MKVYGLIGKP VSHSLSPVMH NALFRKYGID AVYVTFEVEE LGKAIDGVRA LGISGLNVTM 70 80 90 100 110 120 PYKEVVTKFL DELSEDAREI NSVNTIINLE GSLIGYTTDG VGARKALERF TEIEGRNVLI 130 140 150 160 170 180 LGAGGAGKAI AYELSKIANI VVLNRTPSKA KSLEKFGVKG GSLDELPNYV GWADVLINAT 190 200 210 220 230 240 SVGMGTNESL VPRRLLRREL IVMDIVYKPL KTRLLRDAES VGCRVIDGLW MLIYQGAESF 250 260 KLWTGIYPDV ELMRRVSLER LGKG

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49372.1.
PIR	E75161.
RefSeq	NP_126141.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1H7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003127; EBPYRP00000003058; EBPYRG00000003127.
GeneID	1495346.
GenomeReviews	Gene locus PYRAB04500 in contig AL096836_GR.
KEGG	pab:PAB0300.
NMPDR	fig|272844.1.peg.470.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022681.
HOGENOM	HBG553408.
OMA	FELAKDN.
PhylomeDB	Q9V1H7.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0300-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_PYRAB

Accession

Primary (citable) accession number: Q9V1H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program