Q9V1H0 (AROC_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	PYRAB04570
ORF Names:	PAB0307

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Chorismate synthase HAMAP MF_00300		PRO_0000140694

Sequences

	Sequence		Length	Mass (Da)
	Q9V1H0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5AAC7C4D5F272BF4	FASTA	356	39,290
	10 20 30 40 50 60 MRGRVLSFTL FGESHGKGVG VVITGIPPGI KVSHEELVKE LERRKGIPGL STARSEPDNP 70 80 90 100 110 120 IILSGIFRGY TTGTPIAVLF ENKDVDSSYY EDIKDKPRPG HADYPARIKY FGYNDYRGGG 130 140 150 160 170 180 HFSGRLTVGI VTAGYFAKKI LEKYGIRIRA YIKRIGRVEA KQLTLEEILS SENPFCPDEE 190 200 210 220 230 240 AFEKMVEEIE LARREGDSVG GIVEVVAVNV PPGLGGPYEE DIEADLASAF FRIPAVKGVE 250 260 270 280 290 300 FGLGFKVAEK RGSEVNDPYV IRDGKVVTKT NNHGGVLGGI TTGMPIIARI AFKPTPSIYL 310 320 330 340 350 PQRTVDLREM KEVEIKLRGR FDPSIVPRAL PVVEGVMAFV LADHLLFRRV WELKSS

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49379.1.
PIR	D75162.
RefSeq	NP_126148.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1H0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002487; EBPYRP00000002418; EBPYRG00000002487.
GeneID	1495353.
GenomeReviews	Gene locus PYRAB04570 in contig AL096836_GR.
KEGG	pab:PAB0307.
NMPDR	fig|272844.1.peg.477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022458.
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q9V1H0.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	PABY272844:PAB0307-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_PYRAB

Accession

Primary (citable) accession number: Q9V1H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program