Q9V1G8 (TRPB1_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan synthase beta chain 1
EC=4.2.1.20

Gene names

Name:	trpB1
Ordered Locus Names:	PYRAB04590
ORF Names:	PAB2048

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. HAMAP MF_00133
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP MF_00133
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00133
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP MF_00133
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Sequence similarities	Belongs to the TrpB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro tryptophan synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Tryptophan synthase beta chain 1 HAMAP MF_00133		PRO_0000099047
Amino acid modifications
	Modified residue	82	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9V1G8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: DED4A785E5816E72	FASTA	388	42,624
	10 20 30 40 50 60 MWFGKFGGQY VPETLMEPLR ELEKAYKRLK NDEEFNRQLD YYLRTWAGRP TPLYYAERLT 70 80 90 100 110 120 KKVGGAKIYL KREDLLHGGA HKTNNAIGQA LLAKFMGKTR LIAETGAGQH GVATAMAGAL 130 140 150 160 170 180 LGMKVDIYMG AEDVERQKMN VFRMKLLGAN VIPVHTGSKT LKDAINEALR DWVATFEYSH 190 200 210 220 230 240 YLIGSVVGPH PYPIIVRDFQ SVIGREAREQ ILEAEGDLPD VIVACVGGGS NAMGIFYPFV 250 260 270 280 290 300 KDKSVRLIGV EAGGKGIESG KHSASLNAGE IGVFHGMLSY FLQDEEGQIR TTHSIAPGLD 310 320 330 340 350 360 YPGVGPEHAY LKESGRAEYV TVTDEEALRA FHELSRTEGI IPALESAHAV AYAIKLAREM 370 380 SRDDVIIVNL SGRGDKDLDI VLKVSGNV

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49381.1.
PIR	F75162.
RefSeq	NP_126150.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1G8.
SMR	Q9V1G8. Positions 1-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003669; EBPYRP00000003600; EBPYRG00000003669.
GeneID	1495355.
GenomeReviews	Gene locus PYRAB04590 in contig AL096836_GR.
KEGG	pab:PAB2048.
NMPDR	fig|272844.1.peg.479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022951.
HOGENOM	HBG303148.
OMA	LKREDLC.
PhylomeDB	Q9V1G8.
ProtClustDB	PRK04346.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2048-MONOMER.
Family and domain databases
HAMAP	MF_00133. Trp_synth_beta. [Tree]
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR006653. Trp_synth_b_CS. IPR006654. Trp_synth_beta. IPR023026. Trp_synth_beta/beta-like. [Graphical view]
KO	K01696.
PANTHER	PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00263. TrpB. 1 hit.
PROSITE	PS00168. TRP_SYNTHASE_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPB1_PYRAB

Accession

Primary (citable) accession number: Q9V1G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program