Q9V1G7 (TRPF_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	PYRAB04600
ORF Names:	PAB2047

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP MF_00135
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP MF_00135		PRO_0000154410

Sequences

	Sequence		Length	Mass (Da)
	Q9V1G7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2BC8503E3F2F304B	FASTA	208	23,450
	10 20 30 40 50 60 MFVKVCGVKS LEELEIVEKY ADATGVVVNS KSKRNVPLDA AREIISSAKI PVFLVSTMKN 70 80 90 100 110 120 REDWEVAIER TEARYIQIHS DVEPSLLPYL KDEYGVEIMK AFRVPQESEN PERDAQMLLK 130 140 150 160 170 180 KIRKYEADLI LLDTGAGSGK MHDLRVTRIV AEEIPVVVAG GLKPENVEMV IKLVKPFGVD 190 200 VSSGVERNGK KDEELVREFV RRAKNVVR

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49382.1.
PIR	G75162.
RefSeq	NP_126151.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1G7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002915; EBPYRP00000002846; EBPYRG00000002915.
GeneID	1495356.
GenomeReviews	Gene locus PYRAB04600 in contig AL096836_GR.
KEGG	pab:PAB2047.
NMPDR	fig|272844.1.peg.480.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022701.
HOGENOM	HBG554803.
OMA	GFITEVP.
PhylomeDB	Q9V1G7.
ProtClustDB	PRK01222.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2047-MONOMER.
Family and domain databases
HAMAP	MF_00135. PRAI. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01817.
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_PYRAB

Accession

Primary (citable) accession number: Q9V1G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program