Q9V1G4 (TRPD_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate phosphoribosyltransferase
EC=2.4.2.18

Gene names

Name:	trpD
Ordered Locus Names:	PYRAB04630
ORF Names:	PAB2044

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00211
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. HAMAP MF_00211
Sequence similarities	Belongs to the anthranilate phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Anthranilate phosphoribosyltransferase HAMAP MF_00211		PRO_0000154518

Sequences

	Sequence		Length	Mass (Da)
	Q9V1G4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 75BEFCE3A82E3BCD	FASTA	324	35,296
	10 20 30 40 50 60 MLEKIINREN LSFEEAYNLF KELMNESDVR IAAYLAAFQT KGYTAEEIAG LAKAMRDYAI 70 80 90 100 110 120 KLELGEVADT AGTGGDGSSS INVSTASALI LSAFTKVAKH GNVSITSKSG SANVLEALGL 130 140 150 160 170 180 NIKIPPEKAR KMIEKTNFTF IFAPMYHPAL KRIMPVRREL KVKTVFNILG PLANPAEPKF 190 200 210 220 230 240 QVLGVNSPDL VEKMAEALSF LGVERALVVH GMGLDEVNPR GETIVAEVNG EDIDMYTLTP 250 260 270 280 290 300 EDFGVERVKV VPCNSPQESA ERIKAVLRGE GKVEDRNFIL INASAALYAS KVAEDFREGV 310 320 ELVKGILGEP MSKKLEEIIC TSRS

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49385.1.
PIR	B75163.
RefSeq	NP_126154.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1G4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002295; EBPYRP00000002226; EBPYRG00000002295.
GeneID	1495359.
GenomeReviews	Gene locus PYRAB04630 in contig AL096836_GR.
KEGG	pab:PAB2044.
NMPDR	fig|272844.1.peg.483.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023294.
HOGENOM	HBG559996.
OMA	VVDTCGT.
PhylomeDB	Q9V1G4.
ProtClustDB	PRK00188.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2044-MONOMER.
Family and domain databases
HAMAP	MF_00211. TrpD. [Tree]
InterPro	IPR005940. Anthranilate_Pribosyl_Tfrase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR020072. Glycosyl_Trfase_fam3_subgr_N. [Graphical view]
Gene3D	G3DSA:1.20.970.10. Glyco_trans_3. 2 hits. G3DSA:3.40.1030.10. Glyco_trans_3. 2 hits.
KO	K00766.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit.
TIGRFAMs	TIGR01245. TrpD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPD_PYRAB

Accession

Primary (citable) accession number: Q9V1G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program