Q9V1G3 (TRPC_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	PYRAB04640
ORF Names:	PAB2043

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_0000154297

Sequences

	Sequence		Length	Mass (Da)
	Q9V1G3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 061890FECF394417	FASTA	229	25,737
	10 20 30 40 50 60 MVIFGLSRRI KRCTKNPIIA ELKVYSPKYG DLLRGRDPLE ILRRYERAGA VGISYITDPK 70 80 90 100 110 120 YFRGNFDFFK RLCKETELPV LRKDFITTKE EIEKTAEAGG SAVLLITRLL KDKLPEFVDH 130 140 150 160 170 180 AREHGLDTLV EVHTLEELKI AIQTNSTMIG INNRDIGKLE LDDGNVSLTA KLAPLIPDKF 190 200 210 220 VKVSESGITT LEDLKVALKY ADAALIGTAL MKTEDPEKLL KSFVEAKIC

References

[1]

"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49386.1.
PIR	C75163.
RefSeq	NP_126155.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V1G3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000003280; EBPYRP00000003211; EBPYRG00000003280.
GeneID	1495360.
GenomeReviews	Gene locus PYRAB04640 in contig AL096836_GR.
KEGG	pab:PAB2043.
NMPDR	fig|272844.1.peg.484.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022896.
HOGENOM	HBG540956.
OMA	QANAIKN.
PhylomeDB	Q9V1G3.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	PABY272844:PAB2043-MONOMER.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PYRAB

Accession

Primary (citable) accession number: Q9V1G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program