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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi90 – 94GTPBy similarity5
Nucleotide bindingi146 – 149GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Synonyms:aif2G
Ordered Locus Names:PYRAB04670
ORF Names:PAB2040
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374591 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.

Protein-protein interaction databases

STRINGi272844.PAB2040.

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Turni20 – 23Combined sources4
Helixi24 – 32Combined sources9
Helixi41 – 44Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi52 – 60Combined sources9
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Turni74 – 76Combined sources3
Beta strandi81 – 90Combined sources10
Helixi94 – 103Combined sources10
Helixi105 – 107Combined sources3
Beta strandi109 – 116Combined sources8
Beta strandi119 – 121Combined sources3
Helixi124 – 136Combined sources13
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Helixi153 – 167Combined sources15
Turni171 – 174Combined sources4
Beta strandi177 – 179Combined sources3
Turni182 – 185Combined sources4
Helixi188 – 198Combined sources11
Beta strandi211 – 218Combined sources8
Beta strandi234 – 242Combined sources9
Beta strandi249 – 260Combined sources12
Beta strandi263 – 278Combined sources16
Beta strandi281 – 286Combined sources6
Beta strandi288 – 290Combined sources3
Beta strandi292 – 298Combined sources7
Helixi300 – 302Combined sources3
Helixi304 – 306Combined sources3
Turni307 – 310Combined sources4
Beta strandi312 – 314Combined sources3
Beta strandi322 – 332Combined sources11
Beta strandi337 – 339Combined sources3
Helixi340 – 343Combined sources4
Beta strandi353 – 358Combined sources6
Beta strandi361 – 371Combined sources11
Beta strandi374 – 384Combined sources11
Beta strandi390 – 397Combined sources8
Beta strandi400 – 410Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJZX-ray1.85A2-411[»]
1KK0X-ray1.95A2-411[»]
1KK1X-ray1.80A2-411[»]
1KK2X-ray2.10A2-411[»]
1KK3X-ray1.90A2-411[»]
ProteinModelPortaliQ9V1G0.
SMRiQ9V1G0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9V1G0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 203tr-type GAdd BLAST195

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKSRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CPNCGRYSTS PVCPYCGHET EFVRRVSFID APGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIEGT VAENAPIIPI SALHGANIDV LVKAIEDFIP
210 220 230 240 250
TPKRDPNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGVGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWDSLRLEV HLLERVVGTE QELKVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTGL GKDEIEVKLQ IPVCAEPGDR VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):44,931
Last modified:May 1, 2000 - v1
Checksum:i4C7E60EC5A8C837D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49389.1.
HE613800 Genomic DNA. Translation: CCE69850.1.
PIRiF75163.
RefSeqiWP_010867591.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49389; CAB49389; PAB2040.
GeneIDi1495363.
KEGGipab:PAB2040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49389.1.
HE613800 Genomic DNA. Translation: CCE69850.1.
PIRiF75163.
RefSeqiWP_010867591.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJZX-ray1.85A2-411[»]
1KK0X-ray1.95A2-411[»]
1KK1X-ray1.80A2-411[»]
1KK2X-ray2.10A2-411[»]
1KK3X-ray1.90A2-411[»]
ProteinModelPortaliQ9V1G0.
SMRiQ9V1G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB2040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49389; CAB49389; PAB2040.
GeneIDi1495363.
KEGGipab:PAB2040.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Miscellaneous databases

EvolutionaryTraceiQ9V1G0.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_PYRAB
AccessioniPrimary (citable) accession number: Q9V1G0
Secondary accession number(s): G8ZGH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.