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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi90 – 94GTPBy similarity5
Nucleotide bindingi146 – 149GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-506-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Synonyms:aif2G
Ordered Locus Names:PYRAB04670
ORF Names:PAB2040
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374591 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.

Protein-protein interaction databases

STRINGi272844.PAB2040

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Turni20 – 23Combined sources4
Helixi24 – 32Combined sources9
Helixi41 – 44Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi52 – 60Combined sources9
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Turni74 – 76Combined sources3
Beta strandi81 – 90Combined sources10
Helixi94 – 103Combined sources10
Helixi105 – 107Combined sources3
Beta strandi109 – 116Combined sources8
Beta strandi119 – 121Combined sources3
Helixi124 – 136Combined sources13
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Helixi153 – 167Combined sources15
Turni171 – 174Combined sources4
Beta strandi177 – 179Combined sources3
Turni182 – 185Combined sources4
Helixi188 – 198Combined sources11
Beta strandi211 – 218Combined sources8
Beta strandi234 – 242Combined sources9
Beta strandi249 – 260Combined sources12
Beta strandi263 – 278Combined sources16
Beta strandi281 – 286Combined sources6
Beta strandi288 – 290Combined sources3
Beta strandi292 – 298Combined sources7
Helixi300 – 302Combined sources3
Helixi304 – 306Combined sources3
Turni307 – 310Combined sources4
Beta strandi312 – 314Combined sources3
Beta strandi322 – 332Combined sources11
Beta strandi337 – 339Combined sources3
Helixi340 – 343Combined sources4
Beta strandi353 – 358Combined sources6
Beta strandi361 – 371Combined sources11
Beta strandi374 – 384Combined sources11
Beta strandi390 – 397Combined sources8
Beta strandi400 – 410Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJZX-ray1.85A2-411[»]
1KK0X-ray1.95A2-411[»]
1KK1X-ray1.80A2-411[»]
1KK2X-ray2.10A2-411[»]
1KK3X-ray1.90A2-411[»]
ProteinModelPortaliQ9V1G0
SMRiQ9V1G0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9V1G0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 203tr-type GAdd BLAST195

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563 Archaea
COG5257 LUCA
HOGENOMiHOG000229292
KOiK03242
OMAiCPQPQTK
OrthoDBiPOG093Z03P8

Family and domain databases

CDDicd15490 eIF2_gamma_III, 1 hit
HAMAPiMF_00119 eIF_2_gamma, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR022424 TIF2_gsu
IPR015256 TIF2_gsu_C
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173 eIF2_C, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03680 eif2g_arch, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKSRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CPNCGRYSTS PVCPYCGHET EFVRRVSFID APGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIEGT VAENAPIIPI SALHGANIDV LVKAIEDFIP
210 220 230 240 250
TPKRDPNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGVGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWDSLRLEV HLLERVVGTE QELKVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTGL GKDEIEVKLQ IPVCAEPGDR VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):44,931
Last modified:May 1, 2000 - v1
Checksum:i4C7E60EC5A8C837D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA Translation: CAB49389.1
HE613800 Genomic DNA Translation: CCE69850.1
PIRiF75163
RefSeqiWP_010867591.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49389; CAB49389; PAB2040
GeneIDi1495363
KEGGipab:PAB2040
PATRICifig|272844.11.peg.494

Similar proteinsi

Entry informationi

Entry nameiIF2G_PYRAB
AccessioniPrimary (citable) accession number: Q9V1G0
Secondary accession number(s): G8ZGH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome
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Main funding by: National Institutes of Health