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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPBy similarity
Nucleotide bindingi90 – 945GTPBy similarity
Nucleotide bindingi146 – 1494GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Synonyms:aif2G
Ordered Locus Names:PYRAB04670
ORF Names:PAB2040
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Translation initiation factor 2 subunit gammaPRO_0000137459Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.

Protein-protein interaction databases

STRINGi272844.PAB2040.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 179Combined sources
Turni20 – 234Combined sources
Helixi24 – 329Combined sources
Helixi41 – 444Combined sources
Beta strandi47 – 493Combined sources
Beta strandi52 – 609Combined sources
Turni62 – 643Combined sources
Beta strandi67 – 726Combined sources
Turni74 – 763Combined sources
Beta strandi81 – 9010Combined sources
Helixi94 – 10310Combined sources
Helixi105 – 1073Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi119 – 1213Combined sources
Helixi124 – 13613Combined sources
Beta strandi141 – 1466Combined sources
Helixi148 – 1503Combined sources
Helixi153 – 16715Combined sources
Turni171 – 1744Combined sources
Beta strandi177 – 1793Combined sources
Turni182 – 1854Combined sources
Helixi188 – 19811Combined sources
Beta strandi211 – 2188Combined sources
Beta strandi234 – 2429Combined sources
Beta strandi249 – 26012Combined sources
Beta strandi263 – 27816Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi292 – 2987Combined sources
Helixi300 – 3023Combined sources
Helixi304 – 3063Combined sources
Turni307 – 3104Combined sources
Beta strandi312 – 3143Combined sources
Beta strandi322 – 33211Combined sources
Beta strandi337 – 3393Combined sources
Helixi340 – 3434Combined sources
Beta strandi353 – 3586Combined sources
Beta strandi361 – 37111Combined sources
Beta strandi374 – 38411Combined sources
Beta strandi390 – 3978Combined sources
Beta strandi400 – 41011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJZX-ray1.85A2-411[»]
1KK0X-ray1.95A2-411[»]
1KK1X-ray1.80A2-411[»]
1KK2X-ray2.10A2-411[»]
1KK3X-ray1.90A2-411[»]
ProteinModelPortaliQ9V1G0.
SMRiQ9V1G0. Positions 7-411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9V1G0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 203195tr-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9V1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKSRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CPNCGRYSTS PVCPYCGHET EFVRRVSFID APGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIEGT VAENAPIIPI SALHGANIDV LVKAIEDFIP
210 220 230 240 250
TPKRDPNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGVGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWDSLRLEV HLLERVVGTE QELKVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTGL GKDEIEVKLQ IPVCAEPGDR VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):44,931
Last modified:May 1, 2000 - v1
Checksum:i4C7E60EC5A8C837D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49389.1.
HE613800 Genomic DNA. Translation: CCE69850.1.
PIRiF75163.
RefSeqiWP_010867591.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB49389; CAB49389; PAB2040.
GeneIDi1495363.
KEGGipab:PAB2040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA. Translation: CAB49389.1.
HE613800 Genomic DNA. Translation: CCE69850.1.
PIRiF75163.
RefSeqiWP_010867591.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJZX-ray1.85A2-411[»]
1KK0X-ray1.95A2-411[»]
1KK1X-ray1.80A2-411[»]
1KK2X-ray2.10A2-411[»]
1KK3X-ray1.90A2-411[»]
ProteinModelPortaliQ9V1G0.
SMRiQ9V1G0. Positions 7-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB2040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49389; CAB49389; PAB2040.
GeneIDi1495363.
KEGGipab:PAB2040.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Miscellaneous databases

EvolutionaryTraceiQ9V1G0.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_PYRAB
AccessioniPrimary (citable) accession number: Q9V1G0
Secondary accession number(s): G8ZGH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.