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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-525-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PYRAB04840
ORF Names:PAB0323
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197251 – 571Glutamate--tRNA ligaseAdd BLAST571

Proteomic databases

PRIDEiQ9V1E3

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0323

Structurei

3D structure databases

ProteinModelPortaliQ9V1E3
SMRiQ9V1E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 116"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V1E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVERIALKY ALINAIEHGG KANPKAVIGK VLGENPELRS KAREIVPIIN
60 70 80 90 100
KVVEEVNSLS LDEQKAKLME IYPEYFEKKE EKKEEKKGLP PLPKAEKGKV
110 120 130 140 150
VTRFAPNPDG AFHLGNARAA ILSYEYAKMY GGKFILRFDD TDPKVKRPEP
160 170 180 190 200
IFYEMIIEDL EWLGIKPDEI VYASDRLELY YKYAEELIKM GKAYVCTCKP
210 220 230 240 250
EKFRELRDKG IPCPHRDEPV EVQLERWRKM LNGEYKEGEA VVRIKTDLNH
260 270 280 290 300
PNPAVRDWPA LRIVDNPNHP RAGNKYRVWP LYNFASAIDD HELGVTHIFR
310 320 330 340 350
GQEHAENETR QRYIYEYFGW EYPVTVHHGR LSIEGVILSK SKTRKGIEEG
360 370 380 390 400
KYLGWDDPRL GTIRALRRRG ILPEAIKELI IEVGLKKSDA TVSWDNLAAI
410 420 430 440 450
NRKLVDPIAN RYFFVADPVP MEVEGAPEFI AKIPLHPDHP ERGTRELRFT
460 470 480 490 500
PGKPIYVSKD DLDLLKPGSF VRLKDLFNVE IVEVGEKIKA KFHSFEYEIA
510 520 530 540 550
RKNKWRMIHW VPEGRPCEVI IPEGDELIVR KGLLEKDANV KAGEIVQFER
560 570
FGFVRIDKIE GEKVVAIYAH K
Length:571
Mass (Da):65,920
Last modified:May 1, 2000 - v1
Checksum:iD7BA5D954B1A8AC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA Translation: CAB49406.1
HE613800 Genomic DNA Translation: CCE69868.1
PIRiG75165
RefSeqiWP_010867608.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49406; CAB49406; PAB0323
GeneIDi1495381
KEGGipab:PAB0323
PATRICifig|272844.11.peg.512

Similar proteinsi

Entry informationi

Entry nameiSYE_PYRAB
AccessioniPrimary (citable) accession number: Q9V1E3
Secondary accession number(s): G8ZGI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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