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Q9V1E3

- SYE_PYRAB

UniProt

Q9V1E3 - SYE_PYRAB

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:PYRAB04840
    ORF Names:PAB0323
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571Glutamate--tRNA ligasePRO_0000119725Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272844.PAB0323.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9V1E3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi106 – 11611"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9V1E3-1 [UniParc]FASTAAdd to Basket

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    MEVERIALKY ALINAIEHGG KANPKAVIGK VLGENPELRS KAREIVPIIN    50
    KVVEEVNSLS LDEQKAKLME IYPEYFEKKE EKKEEKKGLP PLPKAEKGKV 100
    VTRFAPNPDG AFHLGNARAA ILSYEYAKMY GGKFILRFDD TDPKVKRPEP 150
    IFYEMIIEDL EWLGIKPDEI VYASDRLELY YKYAEELIKM GKAYVCTCKP 200
    EKFRELRDKG IPCPHRDEPV EVQLERWRKM LNGEYKEGEA VVRIKTDLNH 250
    PNPAVRDWPA LRIVDNPNHP RAGNKYRVWP LYNFASAIDD HELGVTHIFR 300
    GQEHAENETR QRYIYEYFGW EYPVTVHHGR LSIEGVILSK SKTRKGIEEG 350
    KYLGWDDPRL GTIRALRRRG ILPEAIKELI IEVGLKKSDA TVSWDNLAAI 400
    NRKLVDPIAN RYFFVADPVP MEVEGAPEFI AKIPLHPDHP ERGTRELRFT 450
    PGKPIYVSKD DLDLLKPGSF VRLKDLFNVE IVEVGEKIKA KFHSFEYEIA 500
    RKNKWRMIHW VPEGRPCEVI IPEGDELIVR KGLLEKDANV KAGEIVQFER 550
    FGFVRIDKIE GEKVVAIYAH K 571
    Length:571
    Mass (Da):65,920
    Last modified:May 1, 2000 - v1
    Checksum:iD7BA5D954B1A8AC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248284 Genomic DNA. Translation: CAB49406.1.
    HE613800 Genomic DNA. Translation: CCE69868.1.
    PIRiG75165.
    RefSeqiNP_126175.1. NC_000868.1.
    WP_010867608.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB49406; CAB49406; PAB0323.
    GeneIDi1495381.
    KEGGipab:PAB0323.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248284 Genomic DNA. Translation: CAB49406.1 .
    HE613800 Genomic DNA. Translation: CCE69868.1 .
    PIRi G75165.
    RefSeqi NP_126175.1. NC_000868.1.
    WP_010867608.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali Q9V1E3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB0323.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB49406 ; CAB49406 ; PAB0323 .
    GeneIDi 1495381.
    KEGGi pab:PAB0323.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiSYE_PYRAB
    AccessioniPrimary (citable) accession number: Q9V1E3
    Secondary accession number(s): G8ZGI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3