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Protein

AMP phosphorylase

Gene

deoA

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-616-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Name:deoA
Ordered Locus Names:PYRAB05650
ORF Names:PAB1982
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590901 – 503AMP phosphorylaseAdd BLAST503

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1982

Structurei

3D structure databases

ProteinModelPortaliQ9V163
SMRiQ9V163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR009010 Asp_de-COase-like_dom_sf
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF50692 SSF50692, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKVRILNI RSGHFDVFIN PKDAQEWKLH PNDLVKIESG KRSIYGSVVI
60 70 80 90 100
GDFVESGEVG LSLDILDAYQ FSEGELVSIT PSETPESVRY IKKKMRGEKL
110 120 130 140 150
RKVEIETIVR DIVDRKLRNT EISALVTAIE VNGLDMDEIA ALTIAMAETG
160 170 180 190 200
DMLDIDRKPI MDVHSIGGVP GNKTNIIVVP IVAAAGLTIP KTSSRAITSA
210 220 230 240 250
AGTADVVEVF TNVTLSLDEI KRIVEKIGAC LVWGGALNLA PADDLTIHVE
260 270 280 290 300
RRLSLDPRGL MLASIMSKKY AIGSQYILID IPTGKGAKVE TMEEARSLAK
310 320 330 340 350
DFIELGKKLG QYVEVAITYG GQPIGYTVGP ALEAKEALET LMTGKGPGSL
360 370 380 390 400
VEKALGLAGI LLEMGGVAPR GMGKKVAREI LESGKAYEKI KEIIEEQGGD
410 420 430 440 450
PNIKPEDIPI GDKTYTIHAQ TSGYVTGIDN KAITAIAREA GAPEDKGAGV
460 470 480 490 500
KLHVKVGEKV KEGDPLFTIH AESESRLDKA IILARRLEPI KIEGMVLQVL

GNL
Length:503
Mass (Da):54,198
Last modified:August 29, 2003 - v2
Checksum:iBDD7A239E1777362
GO

Sequence cautioni

The sequence CAB49487 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA Translation: CAB49487.1 Different initiation.
HE613800 Genomic DNA Translation: CCE69956.1
PIRiH75175
RefSeqiWP_048146577.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49487; CAB49487; PAB1982
GeneIDi1495469
KEGGipab:PAB1982
PATRICifig|272844.11.peg.602

Similar proteinsi

Entry informationi

Entry nameiAMPPA_PYRAB
AccessioniPrimary (citable) accession number: Q9V163
Secondary accession number(s): G8ZJ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health