Q9V163 (TYPH_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	PYRAB05650
ORF Names:	PAB1982

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence caution	The sequence CAB49487.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000059090

Sequences

	Sequence		Length	Mass (Da)
	Q9V163 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: BDD7A239E1777362	FASTA	503	54,198
	10 20 30 40 50 60 MRAKVRILNI RSGHFDVFIN PKDAQEWKLH PNDLVKIESG KRSIYGSVVI GDFVESGEVG 70 80 90 100 110 120 LSLDILDAYQ FSEGELVSIT PSETPESVRY IKKKMRGEKL RKVEIETIVR DIVDRKLRNT 130 140 150 160 170 180 EISALVTAIE VNGLDMDEIA ALTIAMAETG DMLDIDRKPI MDVHSIGGVP GNKTNIIVVP 190 200 210 220 230 240 IVAAAGLTIP KTSSRAITSA AGTADVVEVF TNVTLSLDEI KRIVEKIGAC LVWGGALNLA 250 260 270 280 290 300 PADDLTIHVE RRLSLDPRGL MLASIMSKKY AIGSQYILID IPTGKGAKVE TMEEARSLAK 310 320 330 340 350 360 DFIELGKKLG QYVEVAITYG GQPIGYTVGP ALEAKEALET LMTGKGPGSL VEKALGLAGI 370 380 390 400 410 420 LLEMGGVAPR GMGKKVAREI LESGKAYEKI KEIIEEQGGD PNIKPEDIPI GDKTYTIHAQ 430 440 450 460 470 480 TSGYVTGIDN KAITAIAREA GAPEDKGAGV KLHVKVGEKV KEGDPLFTIH AESESRLDKA 490 500 IILARRLEPI KIEGMVLQVL GNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ248284 Genomic DNA. Translation: CAB49487.1. Different initiation. HE613800 Genomic DNA. Translation: CCE69956.1.
PIR	H75175.
RefSeq	NP_126256.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9V163.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1982.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB49487; CAB49487; PAB1982.
GeneID	1495469.
KEGG	pab:PAB1982.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	2.40.40.20. 1 hit. 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR009010. Asp_de-COase-like_dom. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_PYRAB

Accession

Primary (citable) accession number: Q9V163
Secondary accession number(s): G8ZJ29

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	August 29, 2003
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program