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Protein

Tryptophan synthase beta chain 2

Gene

trpB2

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-631-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 2 (EC:4.2.1.20)
Gene namesi
Name:trpB2
Synonyms:trpB-2
Ordered Locus Names:PYRAB05790
ORF Names:PAB1970
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000990481 – 440Tryptophan synthase beta chain 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ9V150

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi272844.PAB1970

Structurei

3D structure databases

SMRiQ9V150
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiarCOG01432 Archaea
COG1350 LUCA
HOGENOMiHOG000161709
KOiK06001
OrthoDBiPOG093Z033G

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006316 Trp_synth_b-like
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR43565 PTHR43565, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
PIRSF500824 TrpB_prok, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01415 trpB_rel, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVLPDGRI PRRWYNILPD LPEPLDPPLD PETEEPIDIE KLKRIFAEEL
60 70 80 90 100
VKQEISRERY IEIPGELRKL YSKIGRPTPL FRATNLEKLL GTPARIYFKY
110 120 130 140 150
EGATVTGSHK INTALAQAYY AKKQGIERLV TETGAGQWGT ALSLAGALLG
160 170 180 190 200
LKVRVYMARA SYQQKPYRKT LMRIYGAEVF PSPSENTEVG KRFLKEDPNH
210 220 230 240 250
PGSLGIAISE AIEDVLKDEK ARYSLGSVLN HVLMHQTVIG LEAKEQMEEF
260 270 280 290 300
EEPDVIIGCV GGGSNFAGLA YPFVKDVLDG KSEYEFIAVE PKAAPTMTRG
310 320 330 340 350
VYTYDYGDSA GLTPKLKMHT LGHRYYVPPI HAGGLRYHGL APTLSVLINH
360 370 380 390 400
GIVKPIAYHQ TEVFEAAVLF AKAEGIVPAP ESAHAVKAVI DKALEARREG
410 420 430 440
KEMVILFNLS GHGLLDLKGY EDYLDGKLED YEPRDLPVKS
Length:440
Mass (Da):48,943
Last modified:May 16, 2012 - v2
Checksum:i580BC102EBAB36F5
GO

Sequence cautioni

The sequence CAB49501 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA Translation: CAB49501.1 Different initiation.
HE613800 Genomic DNA Translation: CCE69971.1
PIRiF75177
RefSeqiWP_048146581.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49501; CAB49501; PAB1970
GeneIDi1495484
KEGGipab:PAB1970
PATRICifig|272844.11.peg.617

Similar proteinsi

Entry informationi

Entry nameiTRPB2_PYRAB
AccessioniPrimary (citable) accession number: Q9V150
Secondary accession number(s): G8ZJ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 16, 2012
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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